Regression of biliary cirrhosis following choledochal cyst drainage

Clinicopathological Feature and Surgical Outcome of Choledochal Cyst in Different Age Groups: The Implication of Surgical Timing

“…Prompt surgery may prevent and even improve liver fibrosis. 18 Long-standing reflux of pancreatic juice may contribute to chronic inflammation and subsequent carcinogenesis of the biliary trees. Acute complications of choledochal cystspancreatitis, cholangitis, and obstructive jaundice-are contraindications to corrective surgery and are reported in approximately 15% of patients.…”

Histological Classification of Liver Fibrosis and its Impact on the Postoperative Clinical Course of Patients with Congenital Dilatation of the Bile Duct

“…It has often been reported that delayed diagnosis and treatment results in several complications such as cholangitis, biliary perforation, pancreatitis, cholestatic cirrhosis, stone formation, portal hypertension, and malignancy. [1][2][3][4][5][6] However, all of our patients with CDBD showed improved clinical symptoms and normalized laboratory data after diversion surgery. Even the patient with grade 3 fibrosis had no signs of persistent liver dysfunction, except for a slightly elevated S-TBA after the operation.…”

“…However, some patients suffer persistent liver dysfunction, which may even result in liver cirrhosis. [1][2][3][4][5][6] For such patients, the contributing factor to liver dysfunction could be the presence of liver fibrosis at the time of operation. We evaluated liver fibrosis histologically in biopsy specimens obtained routinely during diversion surgery, and clarified the factors contributing to liver fibrosis and their relationship with the patients' postoperative clinical course.…”

“…The liver dysfunction is thought to be due to biliary obstruction, cholangitis, the reflux of pancreatic juice into the biliary system in association with pancreatico-biliary maljunction (PBM), and immaturity of the liver. [1][2][3][4][5][6] It is often improved by the release of biliary obstruction and discontinuation of the mixing of bile and pancreatic juice after diversion surgery. However, some patients suffer persistent liver dysfunction, which may even result in liver cirrhosis.…”

Experience with choledochal cysts in infants

“…Delayed diagnosis and treatment have however, been associated with increased post-operative morbidity and mortality because of liver failure and its sequel [14,15]. Though follow-up liver biopsy has not been done in our study, literature suggests that liver fibrosis may reverse after successful restoration of biliary-enteric drainage [16,17].…”