Régression complète d’une tumeur myofibroblastique inflammatoire de vessie après antibiothérapie

Delforge, Xavier; Buisson, Philippe; Gourmel, Antoine; Cordonnier, C.; Ricard, J.; Haraux, Élodie

doi:10.1016/j.arcped.2016.03.007

Cited by 4 publications

(3 citation statements)

References 10 publications

(22 reference statements)

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“…Such as antibiotic treatment after the disappearance of lesions. [27] There was also a report of the successful treatment of IMT cases using prednisone and COX-2 inhibition anti-inflammatory. [28] Afterward, there are still some reports in the literature on the use of corticosteroids for the treatment of IMT with good results.…”

Section: Discussionmentioning

confidence: 99%

ALK-negative urachal inflammatory myofibroblastic tumor in an elderly female

Wang

Zhou

et al. 2018

Medicine

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Rationale:Inflammatory myofibroblastic tumor (IMT) is a rare soft tissue lesion, originally reported in the lungs. Occurrence of the IMT was also documented in the digestive system, but rare in the urinary system, especially in the urachus, and little is presently known about IMT.Patient concerns:This study reported a very rare case of urachal IMT in an elderly female patient at the age of 77 who was diagnosed with a lower abdominal mass 2 months ago.Diagnosis:The preoperative diagnosis was urachal carcinoma, which was confirmed to be anaplastic lymphoma kinase (ALK) negative urachal IMT by postoperative histopathology and immunohistochemistry tests.Interventions:Laparoscopic radical urachal carcinoma resection and partial bladder resection was performed under general anesthesia, and the tumor was completely removed.Outcomes:There was no recurrence and metastasis over 22 months of follow-up.Lessons:The urachal IMT occurs mainly in males and nonelderly people with ALK positive while in females with ALK negative. The most common clinical manifestations of urachal IMT are lower abdominal masses; it is very important to distinguish whether the tumor originates from the bladder or the urachus, because the surgical treatment options are completely different. Currently the complete surgical removal of the tumor is the best treatment option for urachal IMT. No other adjuvant therapy is required after operation. All urachal IMT after follow-up showed no recurrence and metastasis, suggesting a good prognosis. However, IMT has malignant potential and it requires a long-term close follow-up check.

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Section: Discussionmentioning

confidence: 99%

ALK-negative urachal inflammatory myofibroblastic tumor in an elderly female

Wang

Zhou

et al. 2018

Medicine

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“…It produced an evident partial response and tumor shrinkage. Very favorable responses to macrolides have been reported in two patients with IMTs of the bladder and the lungs [10,13]. Also, our previous unpublished case of an infant with IMT of the sternum involving pleura thoroughly responded to clarithromycin.…”

Section: Discussionmentioning

confidence: 80%

Therapeutic options in inoperable ROS1-rearranged inflammatory myofibroblastic tumor of the tongue in a child: a case report and literature review

et al. 2021

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Inflammatory myofibroblastic tumor (IMT) is a rare borderline malignancy, usually treated with surgery only. Exceedingly rare cases of inoperable, recurrent, or metastatic IMTs pose a therapeutic challenge. We report successful treatment of a 7-year-old girl with an inoperable anaplastic lymphoma kinase (ALK)-negative IMT of the tongue. The patient underwent various antiinflammatory (steroids, nonsteroidal anti-inflammatory drugs, clarithromycin) and antiproliferative (chemotherapy) therapies to enable tumor regression and complete resection. Ultimately, next-generation sequencing of the tumor revealed a TFG-ROS-1 translocation, allowing for an off-label targeted therapy with crizotinib. Crizotinib treatment caused slight tumor regression but evident change of its structure, allowing for complete nonmutilating resection. Two histopathology examinations revealed complete disappearance of neoplastic cells following therapy. The patient remains disease-free 22 months after the delayed surgery. In children with inoperable ALK-negative IMTs, molecular testing must be performed to identify other targetable oncogenic fusions, including TFG-ROS1.

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“…reported a 73-year-old female patient with ALK-negative primary pulmonary IMT who went into remission on treatment with clarithromycin. [ 31 ] Similarly, Alezra et al . reported a case of an 8-year-old girl with documented bladder IMT that resolved completely after antibiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

Clinico-radiological and pathological characteristics of inflammatory myofibroblastic tumors in children: A retrospective study

Mir

Dar

et al. 2017

Indian J Med Paediatr Oncol

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Purpose:Inflammatory myofibroblastic tumors (IMTs) are rare, benign lesions most often seen in the lung of young adults but can occur in children, in various sites. They mimic, clinically and radiologically, malignant tumors – especially sarcomas and lymphomas. The aim was to review the clinical, radiological, and pathological data of children with a diagnosis of IMT referred to our department.Materials and Methods:This retrospective study was conducted at the Department of Medical and Paediatric Oncology, Regional Cancer Centre, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India from January 2014 to December 2015.Results:Among 288 pediatric tumors registered during the study, 5 (1.73%) had the diagnosis of IMTs. The main symptoms were abdominal distension and pain in 60% (three cases), breathlessness and cough in 20% (one case), and right axillary area swelling in 20% (one case). In three patients, complete surgical excision was done, whereas another patient with retroperitoneal mass had the residual disease and received chemotherapy followed by complete second surgery. In the case of mediastinal IMT, surgery was followed by local radiotherapy. At present, four patients are disease-free and one patient with mediastinal IMT has the residual progressive disease.Conclusion:On presentation, IMT can constitute a formidable challenge, from diagnosis through to treatment.

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Régression complète d’une tumeur myofibroblastique inflammatoire de vessie après antibiothérapie

Cited by 4 publications

References 10 publications

ALK-negative urachal inflammatory myofibroblastic tumor in an elderly female

ALK-negative urachal inflammatory myofibroblastic tumor in an elderly female

Therapeutic options in inoperable ROS1-rearranged inflammatory myofibroblastic tumor of the tongue in a child: a case report and literature review

Clinico-radiological and pathological characteristics of inflammatory myofibroblastic tumors in children: A retrospective study

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