Regressão da fibrose hepática

Andrade, Zilton A.

doi:10.1590/s0037-86822005000600013

Cited by 21 publications

(11 citation statements)

References 36 publications

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“…Contrary to what occurs with liver fibrosis, which may reverse or reduce with parasite treatment; this does not seem to occur with the lung pathology of humans [19,43,44]. For all these reasons it is important to clarify the immune mechanisms involved in the pathogenesis of Sch-PAH, in order to discover more effective therapy targets, acting directly on the proliferative component of PAH.…”

Section: Discussionmentioning

confidence: 99%

TGF beta and IL13 in schistosomiasis mansoni associated pulmonary arterial hypertension; a descriptive study with comparative groups

et al. 2014

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BackgroundIt is suggested that interleukin (IL)-13 and transforming growth factor (TGF)-beta play a role in the pulmonary vascular changes found in animal models of schistosomiasis. The aim of this study was to assess and compare the serum levels of total TGF-beta and IL-13 of patients with schistosomiasis with pulmonary arterial hypertension (PAH) and patients with schistosomiasis without PAH.Methods34 patients from the schistosomiasis outpatient clinic of the Hospital das Clinicas, Recife, Pernambuco, Brazil, without PAH assessed by echocardiography and 34 patients from the Reference Centre of Pulmonary Hypertension of Pronto Socorro Cardiológico de Pernambuco, Recife, Brazil with PAH, confirmed by right heart catheterization, were enrolled on the study. Both groups presented with schistosomal periportal fibrosis after abdominal ultrasound. Serum levels of TGF-beta1 and IL-13 were determined by ELISA. Student t test to independent samples, Mann-Whitney test to nonparametric variables, Pearson correlation test for correlation analyses and Fisher Chi-squared test to compare categorical analyses were used.ResultsThe median value of TGF-beta1 was significantly higher in patients with PAH (22496.9 pg/ml, interquartile range [IR] 15936.7 – 32087.8) than in patients without PAH (13629.9 pg/ml, IR: 10192.2- 22193.8) (p = 0.006). There was no difference in the median value of IL-13 in the group with Sch-PAH compared to patients without Sch-PAH (p > 0.05).ConclusionOur results suggest that TGF-beta possibly plays a role in the pathogenesis of schistosomiasis-associated PAH.

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Section: Discussionmentioning

confidence: 99%

TGF beta and IL13 in schistosomiasis mansoni associated pulmonary arterial hypertension; a descriptive study with comparative groups

et al. 2014

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“…Finally, we should consider that the ultrasonographic study four years after the specific treatment of the population, probably detected fewer alterations than if the study had been carried out on the occasion of the parasitological diagnosis, because it is known that the reversion, even if only partial, of the fibrosis and the consequent functional alterations, may occur after specific treatment 1 . In this study we did not perform physical examination, so it was not possible to compare the clinical forms obtained by this approach with the ultrasound.…”

Section: Discussionmentioning

confidence: 98%

Abdominal ultrasound in the evaluation of fibrosis and portal hypertension in an area of schistosomiasis low endemicity

Santo

Azeredo

Teles

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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This study was undertaken in the municipality of Bananal, São Paulo, an endemic area for schistosomiasis with a prevalence under 10% and low parasite load among infected individuals. Our objective was to identify the clinical forms of schistosomiasis among 109 patients in whom the disease had been diagnosed through direct fecal analysis and who had been medicated with oxamniquine at the time of the Plan for the Intensification of Schistosomiasis Control Actions (1998-2000). These patients were submitted to an abdominal ultrasonography and fecal analysis by Kato-Katz method, four years, on average, after the end of the Plan. Five patients, whose abdominal ultrasound images were compatible with either peripheral or central periportal fibrosis and portal hypertension, were identified. None of the 109 patients presented Schistosoma mansoni eggs at fecal analysis. Ultrasonography is a sensitive, noninvasive diagnostic method that allows a better identification of the extent of liver involvement in schistosomiasis cases.

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“…Since the demonstration that the hepatic fibrosis process may be reversible [11] and considering the great necessity of alternative therapeutic procedures, researchers have investigated anti-fibrotic agents [12]. Few studies are aimed at the relation between hormones and fibrosis.…”

mentioning

confidence: 99%

Chronic hepatitis C and fibrosis: evidences for possible estrogen benefits

2007

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The main injury caused by hepatitis C virus is the hepatic fibrosis, as a result of a chronic inflammatory process in the liver characterized by the deposit of components from the extracellular matrix. The fibrosis development leads to the modification of the hepatic architecture, of the hepatocellular function and to irregularities in the microcirculation. The tissue remodeling process observed in fibrosis has stellate cells, located at the space of Disse, as main acting agents. These cells, in response to a harmful stimulus, undergo phenotypic changes from nonproliferating cells to proliferating cells that express a-smooth-muscle actin (α α α α α-SMA), a process called as transdifferentiation. There are evidences that the oxidative stress is involved in the chronic liver disease and serves as bond between the injury and the hepatic fibrosis. A number of studies suggest that the estrogen, at physiological levels, presents an antifibrogenic action probably through an antioxidant effect, decreasing the levels of lipid peroxidation products in the liver and blood, thus inhibiting the myofibroblastic transformation of stellate cells and contributing for gender-associated differences in relation to the fibrosis development. The aim of this paper was to describe data from literature concerning the interaction between chronic hepatitis C and estrogens, pregnancy, use of oral contraceptives, menopause and hormone reposition therapy.

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Regressão da fibrose hepática

Cited by 21 publications

References 36 publications

TGF beta and IL13 in schistosomiasis mansoni associated pulmonary arterial hypertension; a descriptive study with comparative groups

TGF beta and IL13 in schistosomiasis mansoni associated pulmonary arterial hypertension; a descriptive study with comparative groups

Abdominal ultrasound in the evaluation of fibrosis and portal hypertension in an area of schistosomiasis low endemicity

Chronic hepatitis C and fibrosis: evidences for possible estrogen benefits

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