Registry of Youth Onset Diabetes in India (YDR)

Praveen, Pradeep A.; Madhu, Sri Venkata; Mohan, Viswanathan; Das, Siddhartha; Kakati, Sanjeeb; Shah, Nalini; Chaddha, Manoj; Bhadada, Sanjay Kumar; Das, Ashok Kumar; Shukla, Deepak; Kaur, Tanvir; Tandon, Nikhil

doi:10.1177/1932296816645121

Cited by 44 publications

(28 citation statements)

References 34 publications

(29 reference statements)

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“…18,19 The finding that only 5.2% had T2D in this study is lower than that reported from India (25.8%) and Malaysia (17.7%). 9,10 By contrast, the prevalence of T2D in youth has been reported to be higher than T1D in a study from a tertiary diabetes centre in India (48%) and in Maoris in New Zealand (55%). 20,21 A possible reason for the lower prevalence of T2D in the current study is the presence of undiagnosed patients in the community, as screening for diabetes would usually only occur with the onset of symptoms.…”

Section: Discussionmentioning

confidence: 91%

“…The prevalence of the various aetiological types of diabetes found in this study is similar to those reported from India and Malaysia. 9,10 Both the Indian and Malaysian registries showed that most young patients, diagnosed under 25 and 20 years of age respectively, had T1D (63.9% and 71.8%). The SEARCH study in the USA showed a higher prevalence of T1D (1.94/1000) than T2D (0.48/1000) in subjects diagnosed at age < 20 years; but the SEARCH study also showed that the incidence of both T1D and T2D was increasing.…”

Section: Discussionmentioning

confidence: 99%

“…8 Other countries in Europe, Canada, Australia and Israel have also developed registries for the study of children and adolescents with early onset T2D. 9 From developing nations, India and Malaysia have commenced systematic data collection on diabetes in young people; these studies have, for the most part, shown that T1D is still the most common aetiologic type amongst youth in those countries, although a substantial number of young patients are diagnosed with T2D. 9,10 From India, a multicentre registry of diabetes diagnosed under 25 years of age showed that 63.9% of the subjects had T1D and 25.3% had T2D.…”

Section: Introductionmentioning

confidence: 99%

“…9 From developing nations, India and Malaysia have commenced systematic data collection on diabetes in young people; these studies have, for the most part, shown that T1D is still the most common aetiologic type amongst youth in those countries, although a substantial number of young patients are diagnosed with T2D. 9,10 From India, a multicentre registry of diabetes diagnosed under 25 years of age showed that 63.9% of the subjects had T1D and 25.3% had T2D. 9 In Malaysia, the DiCARE registry showed that the majority (71.8%) of patients under 20 years of age had T1D, whereas 17.7% had T2D and 7.1% had other types of diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 From India, a multicentre registry of diabetes diagnosed under 25 years of age showed that 63.9% of the subjects had T1D and 25.3% had T2D. 9 In Malaysia, the DiCARE registry showed that the majority (71.8%) of patients under 20 years of age had T1D, whereas 17.7% had T2D and 7.1% had other types of diabetes. 10 There are very few studies examining the prevalence of diabetes in youth in Africa.…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of subjects with diabetes mellitus diagnosed before 35 years of age presenting to a tertiary diabetes clinic in Durban, South Africa, from 2003 to 2016

Govender

Elmezughi

Esterhuizen

et al. 2018

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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Background: Most patients diagnosed with diabetes mellitus < 35 years will have type 1 diabetes (T1D). The increase in youthonset type 2 diabetes (T2D) parallels the obesity epidemic and in African subjects ketosis-prone type 2 diabetes (KPD) may occur in this age group. Objectives, setting and subjects: To evaluate the clinical, biochemical and immunologic characteristics of patients diagnosed with diabetes < 35 years presenting to a tertiary diabetes clinic in Durban, South Africa over 13 years. Design: A retrospective chart review of patients < 35 years diagnosed with diabetes was conducted. Data included clinical and laboratory variables, complications and follow-up status. Results: The study included 517 patients of whom 445 (86.1%) were diagnosed with T1D, 27 (5.2%) with T2D, 27 with KPD (5.2%) and 18 (3.5%) with other forms of diabetes. Mean age of the total group was 28 ± 10 years. Subjects with T1D were younger at diagnosis with a lower BMI than both T2D and KPD. HbA1c was higher in subjects with T1D. Overall mortality was low (3.5%) and follow-up was poor in all groups. Conclusion: The majority of young people with diabetes in KwaZulu-Natal, South Africa, have T1D, with small numbers of other types. Glucose control is poor with a high loss to follow-up.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characteristics of subjects with diabetes mellitus diagnosed before 35 years of age presenting to a tertiary diabetes clinic in Durban, South Africa, from 2003 to 2016

Govender

Elmezughi

Esterhuizen

et al. 2018

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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Incidence of type 1 diabetes mellitus in children and adolescents under 20 years of age across 55 countries from 2000 to 2022: A systematic review with meta‐analysis

Hormazábal‐Aguayo,

Ezzatvar,

Huerta‐Uribe

et al. 2023

Diabetes Metabolism Res

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AimsThe aim of this study was to determine the global incidence of type 1 diabetes mellitus (T1DM) in children and adolescents under 20 years of age from 2000 to 2022.Materials and MethodsTwo reviewers searched three electronic databases (PubMed, Web of Science, and CINAHL) for studies published between January 2000 and November 2022. Pooled estimates of T1DM incidence with a 95% confidence interval (CI) per 100,000 person‐years were calculated by country/region, sex, age, and COVID‐19 pandemic period (pre‐COVID‐19 and pandemic).ResultsThe study included 126 studies from 55 countries and 18 regions. The incidence rate (IR) of T1DM from 2000 to 2022 was 14.07 (95%CI, 12.15–16.29) per 100,000 person‐years. Finland and high‐income North America had the highest IR, with 56.81 (95%CI, 55.91–57.73) and 28.77 (95%CI, 26.59–31.13) per 100,000 person‐years, respectively. The IR was 13.37 (95%CI, 10.60–16.88) per 100,000 person‐years in boys and 13.87 (95%CI, 11.51–16.70) per 100,000 person‐years in girls. There were statistically significant differences among different age ranges: 0–4 versus 5–9 and 10–14 years old (p < 0.001); 5–9 versus 15–19 (p < 0.001) and 10–14 versus 15–19 years old (p = 0.003). Finally, during the pandemic period (2020–2022), the IR was 24.84 (95%CI, 17.16–35.96) per 100,000 person‐years, which was higher but not significant compared with the prepandemic period (2017–2019) of 13.56 (95%CI, 7.49–24.56) per 100,000 person‐years (p = 0.090).ConclusionsThe IR of T1DM in children and adolescents under 20 years of age is substantial, especially during the pandemic period, although it varies across regions. More reliable data from additional countries are needed to determine the worldwide incidence of T1DM.

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Diabetes Management in Asia

Shivashankar

Singh

Aravind

et al. 2019

The Diabetes Textbook

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Registry of Youth Onset Diabetes in India (YDR)

Abstract: This registry provides a unique opportunity to study the natural history of youth-onset diabetes in India.

Cited by 44 publications

References 34 publications

Characteristics of subjects with diabetes mellitus diagnosed before 35 years of age presenting to a tertiary diabetes clinic in Durban, South Africa, from 2003 to 2016

Characteristics of subjects with diabetes mellitus diagnosed before 35 years of age presenting to a tertiary diabetes clinic in Durban, South Africa, from 2003 to 2016

Incidence of type 1 diabetes mellitus in children and adolescents under 20 years of age across 55 countries from 2000 to 2022: A systematic review with meta‐analysis

Diabetes Management in Asia

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