Registry of the International Society for Heart and Lung Transplantation: Twenty-fifth Official Adult Heart Transplant Report—2008

The Effect of Gender and Gender Match on Mortality in Pediatric Heart Transplantation

“…Multiple adult heart transplantation studies suggest that organ-recipient gender match improves late mortality (1)(2)(3)(4)(5)(6)(7)(8)(9). The factors impacting this survival advantage are unknown but may include differences in heart mass and ratio of body surface area (BSA) (5,7,10).…”

Indications for Ventricle Assist Devices

“…The International Society for Heart and Lung Transplantation (ISHLT) has reported outcome data on transplant recipients for more than 25 years with data that includes more than 74,000 patients (Taylor et al, 2008). This registry includes data mainly from USA and European countries.…”

“…At present time, ventricle assist devices are an important tool in the management of this kind of patient (Frazier at al, 2001;Miller et al, 2007;Russo et al, 2009). Also, in the last decade, the number of heart transplant recipients supported by ventricle assist devices at the time of transplantation has more than doubled to over 400 per year in the USA (Taylor DO et al, 2008) as well as in European countries. This clearly reflects the need of mechanical circulatory support in patients awaiting transplantation.…”

Myocardial ischemia-reperfusion and cardioprotection: a study with microdialysis in a porcine model

“…The three major components of cold cardioplegic storage are: the interruption of contractions, the induction and continuance of hypothermia, and different additives in the cardioplegic solution to affect metabolic or structural changes (Hearse 1980). With this generally applied method, there are some limitations as donor heart ischemic time continues to be a predictor of mortality (Taylor 2007, Taylor 2008. Poor or no functional recovery of the donor heart is not uncommon.…”

“…Poor or no functional recovery of the donor heart is not uncommon. After heart transplantation, the thirty-day mortality is about 8% (Luckraz 2005) with early graft failure in about 30-40% of these cases (Luckraz 2005, Taylor 2007, Taylor 2008. During the cold storage, anaerobic metabolism continues at a low rate with breakdown of high energy phosphates and accumulation of metabolites (Humphrey 1991, Jamieson 2008.…”