Regiospecific one-pot, combinatorial synthesis of new substituted pyrimido[4,5-$c$]pyridazines as potential monoamine oxidase inhibitors

Abstract

• C. The target compounds were obtained in high yields and were regioisomerically pure after recrystallization. These new heterocycles may act as potential MAO B inhibitors.

A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution

“…Furthermore, pyrimidopyridazine derivatives have a significant interest owing to the fact that they have a potent pharmacological effect as therapeutic agents [15,16,17]. They have monoamine oxidase (MAO) inhibitory effect and subsequent modification on the diazine ring results in different inhibitory activities [18].…”

ZrOCl2.8H2O as a green and efficient catalyst for the expeditious synthesis of substituted 3-arylpyrimido[4,5-c]pyridazines in water

“…Exposure to pyridine has harmful effects on the liver, kidneys, immune systems and reproductive functions, and has potential carcinogenicity. [27][28][29][30][31] Following to recent reports about the application of arylglyoxals (AG) in heterocyclic chemistry, 26,[32][33][34][35][36][37][38][39][40] herein we have applied ZrOCl2•8H2O as recyclable, non-toxic and green catalyst for the regioselective synthesis of 3-arylpyrimido [4,5-c] We also studied the influence of the amount of ZrOCl2•8H2O on the reaction yields. We found that the best yield is obtained when we used the ZrOCl2•8H2O 20 mol% as a catalyst.…”

Synthesis of Some 5-[2-Aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-trione Derivatives by a one-pot, three-component reaction

“…The resulting 5-[2-aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-triones synthesized would appear to be suitable synthetic intermediates for a series of new planar polycyclic heterocycles such as pyrimido [4,5-c]pyrazines 38 and pyrazolo [2,3-d]pyrimidines, 39 with possible pharmaceutical applications.…”