Regioselective Vinylation of Remote Unactivated C(sp³)−H Bonds: Access to Complex Fluoroalkylated Alkenes

Abstract

Regioselective incorporation of ap articular functional group into aliphatic sites by direct activation of unreactive CÀHb onds is of great synthetic value.D espite advances in radical-mediated functionalization of C(sp 3 )ÀH bonds by ah ydrogen-atom transfer process,t he site-selective vinylation of remote C(sp 3 ) À Hb onds still remains underexplored. Reported herein is anew protocol for the regioselective vinylation of unactivated C(sp 3 ) À Hbonds.The remote C(sp 3 ) À Hactivation is promoted by aC-centered radical instead of the commonly used Nand Oradicals.The reaction possesses high product diversity and synthetic efficiency,furnishing aplethora of synthetically valuable Ealkenes bearing tri-/di-/monofluoromethyl and perfluoroalkyl groups.