Regioselective Synthesis, Molecular Descriptors of (1,5‐Disubstituted 1,2,3‐Triazolyl)Coumarin/Quinolone Derivatives and Their Docking Studies against Cancer Targets

Ansary, Inul; Roy, Hiren; Das, Arijit; Mitra, Debanjan; Bandyopadhyay, Amal Kumar

doi:10.1002/slct.201900114

Cited by 9 publications

(2 citation statements)

References 74 publications

(54 reference statements)

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“…Some other coumarin fused 1,2,3-triazole macrocycles were also developed and found to be active against cancer cells. 47–50 The most active hybrid 17 (Fig. 12) with IC 50 = 49 μM only showed moderate activity against the MCF-7 cancer cell line.…”

Section: Coumarin Hybridsmentioning

confidence: 99%

Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies

Koley,

Han,

Soloshonok

et al. 2024

RSC Med. Chem.

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Section: Coumarin Hybridsmentioning

confidence: 99%

Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies

Koley,

Han,

Soloshonok

et al. 2024

RSC Med. Chem.

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“…Although various methods have been reported for preparing 1,2,3‐triazoles, 1,3‐dipolar Huisgen cycloaddition of azide‐alkyne, known as “click reaction”, in the presence of transition metal catalysts is the most effective and popular method for production of this class of materials. Various homogeneous and heterogeneous catalytic systems based on transition metal ions like Pd, Zn, Ru, Ag, etc . have been employed for production of 1,2,3‐triazoles.…”

Section: Introductionmentioning

confidence: 99%

Catalytic Activity of Azido‐Bridged Dinuclear Cu(II)‐Hydrazone Coordination Compound in Green Click Synthesis of 1,2,3‐Triazoles

2020

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Azido bridged dinuclear Cu(II) coordination compound, [Cu 2 (L) 2 (μ-N 3 ) 2 ] (1), was synthesized by the reaction of Cu (NO 3 ) 2 . 3H 2 O, NaN 3 and tridentate NNO-donor hydrazone ligand, (E)-2-cyano-N'-(1-(pyridin-2-yl))(HL), with 2 : 2 : 3 molar ratios in methanol. The obtained compound was characterized by elemental analysis, FT-IR and UV-Vis spectroscopy, TGA analysis and its crystal structure was determined by single crystal X-ray diffraction studies. There is a good agreement between structural and spectroscopic properties of the obtained compound which indicated the ligand is coordinated to the metal ion as mononegative ligand in the iminol form. The obtained compound was used as catalyst in green click synthesis of βhydroxy-1,2,3-triazoles through azide-alkyne-epoxide cycloaddition reaction. The catalytic reactions were carried out in water as a green solvent and the effect of temperature on the activity and selectivity of the catalytic system was investigated. The catalytic studies indicated that azido-bridged Cu(II)-hydrazone coordination compound is an active catalyst for green synthesis of β-hydroxy-1,2,3-triazoles in mild condition.

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Coumarin derivatives with anticancer activities: An update

Song

Fan

Liu

et al. 2020

Archiv der Pharmazie

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Cancer can invade or spread to almost all parts of the body. The increasing morbidity and high mortality of cancer create a great demand for the development of novel anticancer drugs. Coumarin derivatives are ubiquitous in nature and can readily interact with diverse enzymes and receptors in cancer cells via weak bond interactions; hence, coumarin is a highly privileged pharmacophore for the development of novel anticancer agents. This review will focus on the recent development of coumarin hybrids as potential anticancer agents covering articles published from 2019 to 2020.

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Regioselective Synthesis, Molecular Descriptors of (1,5‐Disubstituted 1,2,3‐Triazolyl)Coumarin/Quinolone Derivatives and Their Docking Studies against Cancer Targets

Cited by 9 publications

References 74 publications

Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies

Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies

Catalytic Activity of Azido‐Bridged Dinuclear Cu(II)‐Hydrazone Coordination Compound in Green Click Synthesis of 1,2,3‐Triazoles

Coumarin derivatives with anticancer activities: An update

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