Regioselective Enzymatic Galactosylation Enabled Divergent Synthesis of Asymmetrical Biantennary Human Milk Oligosaccharides
Hui Xia,
Kan Zhong,
Yun Li
et al.
Abstract:Human milk oligosaccharides (HMOs) are essential nutritional and bioactive components of human breast milk, conferring numerous beneficial effects on neonatal health. The HMO repertoire comprises over 200 unique glycan structures, and more than half of them are branched oligosaccharides. Owing to the structural diversity and complexity, the synthesis of branched HMOs remains challenging, which significantly hinders their functional study. We herein present a highly efficient biomimetic approach for the rapid a… Show more
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