Regioselective Cobalt(II) Catalyzed C–H Functionalization and [3 + 2] Annulation of N-Arylguanidines with 1,3-Diynes
Harish Parihar,
Pooja Yadav,
Natesan Thirupathi
Abstract:8-Quinolinyl directed N-arylguanidines
were subjected
to cobalt(II) catalyzed C–H functionalization/1,3-diyne annulation
under mild conditions to afford 40 alkynylated indole guanidines in
34% to 92% yields. The scope of the substrates was explored. The reported
procedure is mostly regioselective and tolerates various functional
groups in the substrates. The regioselectivity of the reactions was
assessed with the aid of multinuclear NMR spectroscopy and X-ray crystallography.
Competition and labeling experimen… Show more
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