Regioselective C2-lithiation of N-Boc-3-bromopyrroles: a novel approach towards the synthesis and scale-up of 3-(2-formyl-4-methyl-1-H-pyrrol-3-yl)propanoic acid

Palladium Catalyzed C3-(sp2)-H Alkenylation of Pyrroles: A Direct Access to Novel Organic Thermally Activated Delayed Fluorescence (TADF) Materials

“…[9] Despite their high significance in pharmaceuticals and their utility in organic synthesis, only a few literature reports are available for the direct C3-alkenylated pyrrole derivatives. [7,[10][11][12] Though some of these methods have their own merits, however some of these have limitations such as relying on pre-functionalized starting materials, necessity of bulky group on the nitrogen and multi-step approaches to access target compounds. [7,[10][11][12] Interestingly, the alkenylation of the pyrroles by using benzothiazole moiety as a directing group has been rarley explored in the literature.…”

“…[7,[10][11][12] Though some of these methods have their own merits, however some of these have limitations such as relying on pre-functionalized starting materials, necessity of bulky group on the nitrogen and multi-step approaches to access target compounds. [7,[10][11][12] Interestingly, the alkenylation of the pyrroles by using benzothiazole moiety as a directing group has been rarley explored in the literature. Also there are limited reports on the use of benzothiazole moiety as a directing group for the C-H bond functionalization of aromatic/heteroaromatic compounds.…”