Regioselective [6π+2π] cycloaddition of 1,2-dienes to 7-substituted 1,3,5-cycloheptatrienes catalyzed by Ti(acac)2Cl2—Et2AlCl

Triepoxides were synthesized for the first time in high yields (80-85%) by oxidation of substituted bicyclo[4.2.2]deca-2,4,7,9-tetraenes, bicyclo[4.2.2]deca-2,4,7-trienes, and tricyclo[9.4.2.02,10]heptadeca-2,12,14,16-tetraene with an excess of m-chloroperbenzoic acid. The structures of the epoxy derivatives were reliably proved using modern spectral methods and X-ray diffraction analysis. A high antitumor activity in vitro was found for triepoxides against the Jurkat, K562, U937 tumor cell lines and normal fibroblasts.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Regioselective [6π+2π] cycloaddition of 1,2-dienes to 7-substituted 1,3,5-cycloheptatrienes catalyzed by Ti(acac)2Cl2—Et2AlCl

Cited by 2 publications

References 26 publications

Cobalt(I)-catalyzed [6π+2π]-cycloaddition of 1,3-diynes to cyclohepta-1,3,5-triene in the synthesis of new disubstituted bicyclo[4.2.1]nona-2,4,7-trienes

Cobalt(I)-catalyzed [6π+2π]-cycloaddition of 1,3-diynes to cyclohepta-1,3,5-triene in the synthesis of new disubstituted bicyclo[4.2.1]nona-2,4,7-trienes

Synthesis and Antitumor Activity Assay of Epoxy Bicyclo[4.2.2]deca-2,4,7,(9)- tri(tetra)enes and Tricyclo[9.4.2.02,10]heptadeca-2,12,14,16-tetraene

Contact Info

Product

Resources

About