Régions chromosomiques influençant les caractères de production et de qualité des oeufs de poule

Romé, Hélène; Roy, Pascale Le

doi:10.20870/productions-animales.2016.29.1.2521

Cited by 2 publications

(3 citation statements)

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“…Nanoindentation and atomic force microscopy measurements suggest that OPN influences eggshell hardness and nanostructure, which in turn control the mechanical properties of the shell (Athanasiadou et al, 2018). SNPs in chicken SPP1 are associated with eggshell fracture toughness (Dunn et al, 2009;Romé and Le Roy, 2016), which supports a regulatory role for OPN in mineralization. From fishes to mammals, OPN possesses a poly-aspartate motif, which is able to bind calcium and mediates binding to the mineral surface (Supplementary Figure 2; Sodek et al, 2000;Athanasiadou et al, 2018;Weber, 2018).…”

Section: Co-option Of Sibling Bone Proteins Osteopontin (Opn/spp1) and Ovocleidin-116 (Oc-116/mepe) In Eggshell Biomineralizationmentioning

confidence: 86%

“…Proteomic analysis of the chicken eggshell cuticle demonstrated that OCX-32 is one of the most abundant constituents of this non-mineralized region, and could play a major role in the antimicrobial properties of the cuticle (Rose-Martel et al, 2012;Bain et al, 2013). Polymorphisms in the gene coding for OCX-32, RARRES1 (gene synonym: OCX32), are significantly associated with egg production traits (Uemoto et al, 2009;Romé and Le Roy, 2016). In another study, the quantitative trait loci (QTLs) on chromosome 9 were investigated in an F2 generation that was an intercross between two chicken lines divergently selected for eggshell strength (Takahashi et al, 2010).…”

Section: Vertebrate Proteins Recruited In the Eggshell Biomineralization Processmentioning

confidence: 99%

“…In addition to the eggshell, OC-116 was reported in the chicken cortical and medullary bone (Horvat-Gordon et al, 2008). SNP analysis revealed that the MEPE/OC116 gene is associated with shell thickness, elastic modulus and egg shape (Dunn et al, 2009;Romé and Le Roy, 2016). The mammalian ortholog MEPE is involved in bone and teeth mineralization (Bardet et al, 2010a).…”

Section: Co-option Of Sibling Bone Proteins Osteopontin (Opn/spp1) and Ovocleidin-116 (Oc-116/mepe) In Eggshell Biomineralizationmentioning

confidence: 99%

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Evolution of the Avian Eggshell Biomineralization Protein Toolkit – New Insights From Multi-Omics

et al. 2021

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The avian eggshell is a remarkable biomineral, which is essential for avian reproduction; its properties permit embryonic development in the desiccating terrestrial environment, and moreover, are critically important to preserve unfertilized egg quality for human consumption. This calcium carbonate (CaCO3) bioceramic is made of 95% calcite and 3.5% organic matrix; it protects the egg contents against microbial penetration and mechanical damage, allows gaseous exchange, and provides calcium for development of the embryonic skeleton. In vertebrates, eggshell occurs in the Sauropsida and in a lesser extent in Mammalia taxa; avian eggshell calcification is one of the fastest known CaCO3 biomineralization processes, and results in a material with excellent mechanical properties. Thus, its study has triggered a strong interest from the researcher community. The investigation of eggshell biomineralization in birds over the past decades has led to detailed characterization of its protein and mineral constituents. Recently, our understanding of this process has been significantly improved using high-throughput technologies (i.e., proteomics, transcriptomics, genomics, and bioinformatics). Presently, more or less complete eggshell proteomes are available for nine birds, and therefore, key proteins that comprise the eggshell biomineralization toolkit are beginning to be identified. In this article, we review current knowledge on organic matrix components from calcified eggshell. We use these data to analyze the evolution of selected matrix proteins and underline their role in the biological toolkit required for eggshell calcification in avian species. Amongst the panel of eggshell-associated proteins, key functional domains are present such as calcium-binding, vesicle-binding and protein-binding. These technical advances, combined with progress in mineral ultrastructure analyses, have opened the way for new hypotheses of mineral nucleation and crystal growth in formation of the avian eggshell, including transfer of amorphous CaCO3 in vesicles from uterine cells to the eggshell mineralization site. The enrichment of multi-omics datasets for bird species is critical to understand the evolutionary context for development of CaCO3 biomineralization in metazoans, leading to the acquisition of the robust eggshell in birds (and formerly dinosaurs).

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Section: Co-option Of Sibling Bone Proteins Osteopontin (Opn/spp1) and Ovocleidin-116 (Oc-116/mepe) In Eggshell Biomineralizationmentioning

confidence: 86%

Section: Vertebrate Proteins Recruited In the Eggshell Biomineralization Processmentioning

confidence: 99%

Section: Co-option Of Sibling Bone Proteins Osteopontin (Opn/spp1) and Ovocleidin-116 (Oc-116/mepe) In Eggshell Biomineralizationmentioning

confidence: 99%

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Evolution of the Avian Eggshell Biomineralization Protein Toolkit – New Insights From Multi-Omics

et al. 2021

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Avian eggshell biomineralization: an update on its structure, mineralogy and protein tool kit

Gautron

Stapane

Roy

et al. 2021

BMC Mol and Cell Biol

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Background The avian eggshell is a natural protective envelope that relies on the phenomenon of biomineralization for its formation. The shell is made of calcium carbonate in the form of calcite, which contains hundreds of proteins that interact with the mineral phase controlling its formation and structural organization, and thus determine the mechanical properties of the mature biomaterial. We describe its mineralogy, structure and the regulatory interactions that integrate the mineral and organic constituents during eggshell biomineralization. Main Body. We underline recent evidence for vesicular transfer of amorphous calcium carbonate (ACC), as a new pathway to ensure the active and continuous supply of the ions necessary for shell mineralization. Currently more than 900 proteins and thousands of upregulated transcripts have been identified during chicken eggshell formation. Bioinformatic predictions address their functionality during the biomineralization process. In addition, we describe matrix protein quantification to understand their role during the key spatially- and temporally- regulated events of shell mineralization. Finally, we propose an updated scheme with a global scenario encompassing the mechanisms of avian eggshell mineralization. Conclusion With this large dataset at hand, it should now be possible to determine specific motifs, domains or proteins and peptide sequences that perform a critical function during avian eggshell biomineralization. The integration of this insight with genomic data (non-synonymous single nucleotide polymorphisms) and precise phenotyping (shell biomechanical parameters) on pure selected lines will lead to consistently better-quality eggshell characteristics for improved food safety. This information will also address the question of how the evolutionary-optimized chicken eggshell matrix proteins affect and regulate calcium carbonate mineralization as a good example of biomimetic and bio-inspired material design.

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Régions chromosomiques influençant les caractères de production et de qualité des oeufs de poule

Cited by 2 publications

References 30 publications

Evolution of the Avian Eggshell Biomineralization Protein Toolkit – New Insights From Multi-Omics

Evolution of the Avian Eggshell Biomineralization Protein Toolkit – New Insights From Multi-Omics

Avian eggshell biomineralization: an update on its structure, mineralogy and protein tool kit

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