Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid

Dugich-Djordjevic, Millicent M.; Tocco, Georges; Lapchak, Paul A.; Pasinetti, Giulio Maria; Najm, Imad; Baudry, Michel; Hefti, Franz

doi:10.1016/0306-4522(92)90246-x

Cited by 166 publications

(56 citation statements)

References 28 publications

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“…Consistent with this explanation, we found that medium conditioned with KCl-depolarized primary hippocampal cells, but from which the KCl is subsequently removed, can also activate precursor activity (data not shown). It is well known that seizures lead to a marked but transient increase in BDNF mRNA levels in hippocampal neuronal populations (Ballarin et al, 1991;Ernfors et al, 1991;Isackson et al, 1991;Dugich-Djordjevic et al, 1992). We also previously demonstrated that BDNF is essential for the production of neurons from hippocampal progenitor cells (Bull and Bartlett, 2005).…”

Section: Discussionmentioning

confidence: 62%

“…In addition, BDNF is released by hippocampal neuronal populations after seizures (Ballarin et al, 1991;Ernfors et al, 1991;Isackson et al, 1991;Dugich-Djordjevic et al, 1992). Our results show that, when added to primary hippocampal cultures in the presence of 15 mM KCl, anti-human BDNF neutralizing antibody was not able to block the depolarization-induced activation (Fig.…”

Section: Hippocampal Precursor Activation Is Not Occurring In Responsmentioning

confidence: 70%

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Latent Stem and Progenitor Cells in the Hippocampus Are Activated by Neural Excitation

Walker¹,

White²,

Black³

et al. 2008

J. Neurosci.

106

130

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The regulated production of neurons in the hippocampus throughout life underpins important brain functions such as learning and memory. Surprisingly, however, studies have so far failed to identify a resident hippocampal stem cell capable of providing the renewable source of these neurons. Here, we report that depolarizing levels of KCl produce a threefold increase in the number of neurospheres generated from the adult mouse hippocampus. Most interestingly, however, depolarizing levels of KCl led to the emergence of a small subpopulation of precursors (approximately eight per hippocampus) with the capacity to generate very large neurospheres (Ͼ250 m in diameter). Many of these contained cells that displayed the cardinal properties of stem cells: multipotentiality and self-renewal. In contrast, the same conditions led to the opposite effect in the other main neurogenic region of the brain, the subventricular zone, in which neurosphere numbers decreased by ϳ40% in response to depolarizing levels of KCl. Most importantly, we also show that the latent hippocampal progenitor population can be activated in vivo in response to prolonged neural activity found in status epilepticus. This work provides the first direct evidence of a latent precursor and stem cell population in the adult hippocampus, which is able to be activated by neural activity. Because the latent population is also demonstrated to reside in the aged animal, defining the precise mechanisms that underlie its activation may provide a means to combat the cognitive deficits associated with a decline in neurogenesis.

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Section: Discussionmentioning

confidence: 62%

Section: Hippocampal Precursor Activation Is Not Occurring In Responsmentioning

confidence: 70%

Latent Stem and Progenitor Cells in the Hippocampus Are Activated by Neural Excitation

Walker¹,

White²,

Black³

et al. 2008

J. Neurosci.

106

130

View full text Add to dashboard Cite

show abstract

“…The findings that the glutamate analog kainic acid (KA) and the 'y-aminobutyric acid subtype A (GABAA) receptor antagonist bicuculline increase BDNF mRNA levels in hippocampal neurons have led to the hypothesis that the balance between the activity of the GABAergic and glutamatergic systems controls the level of BDNF mRNA in the hippocampus (25)(26)(27)(28). Moreover, stimulation of the septohippocampal pathway transiently increases BDNF mRNA in the hippocampus (29).…”

mentioning

confidence: 99%

Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation.

Metsis

Timmusk

Arenas

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

217

153

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The rat brain-derived neurotropic factor (BDNF) gene consists of four S' exons lnked to separate promoters and one 3' exon encoding the prepro-BDNF protein.To gain sights Into the regulation ofBDNF mRNA expression, probes specific for the different 5' exons were used to study the expresson of BDNF mRNA in the brain. Following a systemic isjection ofthe glutamate analog kainc acid, exon I, HI, and m1 mRNAs increased tanendtly in hippocampus and cerebral cortex. A modest incrase was seen for exon IV, where a new transcription initiation site was induced by this treatment. Pretreatments with the N-methyl-D-aspartate (NMDA) receptor antagnist MK801 or the a-amino-3-hydroxy-5-methyl-4-isoxazoleproplonic acid (AMPA) receptor antagonis 2,3-dihydroxy-6-nitrosulfanoylbenzo(f)quinoxaline revealed two region-spcfic patterns of glutamate receptor-mediated regulation. The first pattern found in neocortex, prform cortex, and amygdala involves regulation of BDNF exon I, UI, and m mRNAs trgh NMDA and AMPA/kainate receptors. The second pattern found In the hippocampus involves regulation of BDNF exon I, U, and HI mRNAs by hig-afnity kainate or metabotropic receptors. Treatment with the -aminobutyric acid subtpe A (GABAA) receptor antagonst bicu e incrased exon I and UI mRNAs in the dentate gyms, and the muscinic receptor agonist plocarpine incasd exon I mRNA mainly in the neocortex. These data show that the four BDNF promoters allow multiple points of BDNF mRNA regulation and suggest that the activation of different subtpes of glutmate receptors differentially regulates the expon of BDNF exon-spech'ic mRNAs In the brain.Brain-derived neurotrophic factor (BDNF; refs. 1 and 2) is a member of the neurotrophin family, which also includes nerve growth factor (NGF) (3), neurotrophin-3 (NT-3) (4-9), and neurotrophin 4/5 (NT-4) (10-12). BDNF promotes the survival of retinal ganglion cells (13) Abbreviations: NGF, nerve growth factor; BDNF, brain-derived neurotrophic factor; NT-3, neurotrophin 3; NT-4, neurotrophin 4; NMDA, N-methyl-D-aspartate; AMPA, a-amino-3-hydroxy-5-methyl-4isoxazolepropionic acid; GABA, 't-aminobutyric acid; KA, kainic acid; NBQX, 2,3-dihydroxy-6nitrosulfanoylbenzo(f)quinoxaline; CNQX, 6-cyano-7-nitroquinoxaline-2,3-dione.

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“…Seizures and excitotoxicity induced a significant increase in BDNF in the injured region (Ballarin et al, 1991;Dugich-Djordjevic et al, 1992;Humpel et al, 1993). As the increase in BDNF always precedes the NPY expression (Reibel et al, 2000) the BDNF overexpression after excitotoxicity may be neuroprotective by inducing NPY production.…”

Section: How Does Npy Modulate Neurodegenation and Neuroprotection?mentioning

confidence: 99%

Neuroprotective Effects of Neuropeptide Y and Y2 and Y5 Receptor Agonists In Vitro and In Vivo

Śmiałowska¹,

Domi²

2012

Neurodegeneration

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Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid

Cited by 166 publications

References 28 publications

Latent Stem and Progenitor Cells in the Hippocampus Are Activated by Neural Excitation

Latent Stem and Progenitor Cells in the Hippocampus Are Activated by Neural Excitation

Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation.

Neuroprotective Effects of Neuropeptide Y and Y2 and Y5 Receptor Agonists In Vitro and In Vivo

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