Abstract. The Andes Mountains span a length of 7,000 km and are important for sustaining regional water supplies. Snow 10 variability across this region has not been studied in detail due to sparse and unevenly distributed instrumental climate data. limited between 8°S and 36°S due high frequency of cloud (>30% of the time) south and north of this range. We ran MannKendall and Theil-Sens analyses to identify significant areas of change in SP and snow line (the line at lower elevation 15 which SP=20%). We evaluated whether these trends in the context of temperature and precipitation (University of Delaware dataset) and climate indices (ENSO, SAM, PDO). North of 29°S has limited snow cover, and few trends in snow persistence were detected. A large area (70,515 km2) with persistent snow cover between 29-36°S experienced a significant loss of snow cover (2-5 fewer days of snow year-1). Snow loss was more pronounced (62%) on the east side of the Andes. We also found a significant increase in the elevation of 10-30 m year-1 south of 29-30°S. Decreasing SP correlates with decreasing 20 precipitation, increasing temperature, and climate indices and it varies with latitude and elevation. ENSO indices better predicted SP conditions north of 31°S, and the SAM better predicted SP south of 31°S.