Geographic regions all have some degree of uncertainty, though this is seldom represented on their maps. Uncertainty of the Great Plains boundary is shown here by comparing 50 previously published maps of the region. These maps were found in a variety of sources, from classic 1930s geographic works to current regional studies on the Internet. By examining this diverse collection, a distinction can be seen between those maps using primarily physical criteria to define the region and those using cultural characteristics, or a combination of these two characteristics. This distinction is supported by trends in boundary shape, size, and even the map's date of publication. The Great Plains is shown as a complex region, subject to the interpretations of individual cartographers, and can be better understood by considering all points of view rather than any single boundary line.