Although flood risk assessments are frequently associated with significant uncertainty, formal uncertainty analyses are the exception rather than the rule. We propose to separate two fundamentally different types of uncertainty in flood risk analyses: aleatory and epistemic uncertainty. Aleatory uncertainty refers to quantities that are inherently variable in time, space or populations of individuals or objects. Epistemic uncertainty results from incomplete knowledge and is related to our inability to understand, measure and describe the system under investigation. The separation between aleatory and epistemic uncertainty is exemplified for the flood risk analysis of the City of Cologne, Germany. This flood risk assessment consists of three modules, (1) flood frequency analysis, (2) inundation estimation, and (3) damage estimation. By the concept of parallel models, the epistemic uncertainty of each module is quantified. The epistemic uncertainty associated with the risk estimate is reduced by introducing additional information into the risk analysis. Finally, the contribution of different modules to the total uncertainty is quantified. The flood risk analysis results in a flood risk curve, representing aleatory uncertainty, and in associated uncertainty bounds, representing epistemic uncertainty. In this way, the separation reveals the uncertainty (epistemic) that can be reduced by more knowledge and the uncertainty (aleatory) that is not reducible.