Regional White Matter Hyperintensity Burden in Automated Segmentation Distinguishes Late-Life Depressed Subjects From Comparison Subjects Matched for Vascular Risk Factors

Sheline, Yvette I.; Price, Joseph L.; Vaishnavi, Sanjeev; Mintun, Mark A.; Deanna, M; Epstein, Adrian A.; Wilkins, Consuelo H.; Snyder, Abraham Z.; Couture, Lars E.; Schechtman, Kenneth B.; McKinstry, Robert C.

doi:10.1176/appi.ajp.2007.07010175

Cited by 193 publications

(172 citation statements)

References 46 publications

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“…Small-sample studies have specifically reported reduced integrity in superior longitudinal fasciculus in various depressive samples, including elderly patients with depression 38,46 , depressive adolescents 47 and adolescents with familial risk for depression 45 , compared with controls. Meta-analytic studies 35,48 and a review 36 also ascertained that the reduction of white matter integrity specifically in superior longitudinal fasciculus may be an important biomarker of the presence of depression.…”

Section: Discussionmentioning

confidence: 99%

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

Shen

Reus

Adams

et al. 2016

Preprint

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Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however, reported reduced hippocampal grey matter volume in MDD and reduced white matter integrity in several brain regions. The use of different diagnostic criteria, scanners and imaging sequences may, however, obscure further anatomical differences. In this study, we tested for differences in subcortical grey matter volume (n = 1157) and white matter integrity (n = 1089) between depressed individuals and controls in the subset of 8590 UK Biobank Imaging study participants who had undergone depression assessments. Whilst we found no significant differences in subcortical volumes, significant reductions were found in depressed individuals versus controls in global white matter integrity, as measured by fractional anisotropy ( Major Depressive Disorder (MDD) is a common psychiatric illness, affecting between 5 and 30% of the population which accounts for around 10% of all days lived with disability 1

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Section: Discussionmentioning

confidence: 99%

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

Shen

Reus

Adams

et al. 2016

Preprint

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“…The presence of subcortical WMLs in late-life depression has been associated with cognitive impairment (Austin et al, 2001;Goodwin, 1997;Herrmann et al, 2007), functional impairment (Steffens et al, 2002), poor treatment outcome (Alexopoulos et al, 2002Chen et al, 2006;Hickie et al, 1995Hickie et al, , 1997Iosifescu et al, 2006;O'Brien et al, 1998;Simpson et al, 1998;Steffens et al, 2001;Taylor et al, 2003b), and a greater risk of subsequent dementia . Although reports in the depression literature have found the WMLs to be mainly located in fronto-striatal circuits (Greenwald et al, 1998;MacFall et al, 2001;O'Brien et al, 2006;Sheline et al, 2008;Taylor et al, 2003a;Videbech et al, 2004), and in the basal ganglia (Videbech, 1997), the relation between lesion characteristics, their interference with specific white matter pathways, severity of symptoms, and disease remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Depression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression

Dalby

Frandsen

Chakravarty

et al. 2010

Psychiatry Research: Neuroimaging

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Cerebral white matter lesions (WMLs) are believed to play an important role in a subset of major depression (MD). We aimed to describe the impact of WMLs on white matter pathways in MD using diffusion tensor imaging (DTI) and magnetization transfer imaging. As a novel approach, we used DTI tractography to assess pathways intersected by WMLs. We examined 22 patients with late-onset MD and 22 age-and gendermatched controls. Parametric maps of fractional anisotropy (FA), apparent diffusion coefficient (ADC), and magnetization transfer ratio (MTR) were obtained to describe tissue integrity. The association between depression severity and the tract-specific localization of WMLs was analyzed on a voxel-by-voxel basis. We showed a significant positive association between depression severity and fiber tracts intersected by WMLs in the left superior longitudinal fasciculus and the right uncinate fasciculus. In both groups, WMLs had significantly lower FA and MTR, and higher ADC than both the tracts they intersected and the normalappearing white matter (NAWM). In turn, the tracts intersected by WMLs had significantly lower FA and higher ADC than the NAWM. In conclusion, depression severity correlates with the tract-specific localization of WMLs. WMLs have a pronounced effect on white matter integrity in the pathways they intersect.

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“…The EOD group did not differ from controls, whereas the LOD group had higher scores than controls in both periventricular and deep WMHs [34]. We did not localize the maximum load of WMHs, but other studies in LOD localized the increased lesion density to relevant regions [56,57,58]. Recent reviews of brain changes in late-life depression [[59], table13, [60,61,62]] concur in concluding that the structural neuroimaging literature shows the involvement of frontolimbic pathways in late-life depression, and this is particularly clear with late onset.…”

Section: Discussionmentioning

confidence: 99%

Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression

Gade

Kristoffersen²,

Kessing

2015

Psychopathology

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Background: The personality trait of neuroticism is strongly related to depression, but depression is etiologically heterogeneous. Late-onset depression (LOD) may be more closely related to vascular factors, and previous studies of neuroticism in LOD versus early-onset depression (EOD) have not been consistent. Method: We examined neuroticism, extraversion and perceived stress in 88 fully remitted depressed patients with a mean age of 60 years and with a history of hospitalization for major depressive disorder. Patients were divided into those with onset after and those with onset before 50 years of age (LOD and EOD, respectively), and the two groups were compared both with each other and with matched control groups of healthy subjects. Results: EOD patients showed increased levels of neuroticism in comparison with both LOD and matched controls, who did not differ. The association between age of onset and neuroticism was confirmed in analyses based on age of depression onset as a continuous variable. Conclusion: Neuroticism may be an etiological factor in EOD but not or less so in LOD. This finding contributes to the growing evidence for etiological differences between early- and late-onset late-life depression.

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Regional White Matter Hyperintensity Burden in Automated Segmentation Distinguishes Late-Life Depressed Subjects From Comparison Subjects Matched for Vascular Risk Factors

Cited by 193 publications

References 46 publications

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

Depression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression

Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression

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