Regional Volume Analysis of the Parkinson Disease Brain in Early Disease Stage: Gray Matter, White Matter, Striatum, and Thalamus

Lee, S. H.; Kim, Sam Soo; Tae, Woo Suk; Choi, J. W.; Koh, Seong Beom; Kwon, Do Young

doi:10.3174/ajnr.a2372

Cited by 71 publications

(49 citation statements)

References 44 publications

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“…This may be related to the negative correlation of age and STN visualization, as advancing age is an obvious factor associated with loss of brain volume. The progression of brain atrophy is reported to be faster in PD, and white matter volume is also reported to be reduced in PD patients compared to healthy controls [6, 21]. Our result is further supported by the fact that dyskinesia has been associated with faster brain atrophy, particularly of frontal lobes [22], which again supports the notion that STN visualization is better in patients with younger age and lesser brain atrophy.…”

Section: Discussionsupporting

confidence: 79%

Subthalamic Nucleus Visualization on Routine Clinical Preoperative MRI Scans: A Retrospective Study of Clinical and Image Characteristics Predicting Its Visualization

Ranjan

Boutet

et al. 2018

Stereotact Funct Neurosurg

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Background: The visualization of the subthalamic nucleus (STN) on magnetic resonance imaging (MRI) is variable. Studies of the contribution of patient-related factors and intrinsic brain volumetrics to STN visualization have not been reported previously. Objective: To assess the visualization of the STN during deep brain stimulation (DBS) surgery in a clinical setting. Methods: Eighty-two patients undergoing pre-operative MRI to plan for STN DBS for Parkinson disease were retrospectively studied. The visualization of the STN and its borders was assessed and scored by 3 independent observers using a 4-point ordinal scale (from 0 = not seen to 3 = excellent visualization). This measure was then correlated with the patients’ clinical information and brain volumes. Results: The mean STN visualization scores were 1.68 and 1.63 for the right and left STN, respectively, with a good interobserver reliability (intraclass correlation coefficient: 0.744). Older age and decreased white matter volume were negatively correlated with STN visualization (p < 0.05). Conclusion: STN visualization is only fair to good on routine MRI with good concordance of interindividual rating. Advancing age and decreased white matter are associated with poor visualization of the STN. Knowledge about factors contributing to poor visualization of the STN could alert a surgeon to modify the imaging strategy to optimize surgical targeting.

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Section: Discussionsupporting

confidence: 79%

Subthalamic Nucleus Visualization on Routine Clinical Preoperative MRI Scans: A Retrospective Study of Clinical and Image Characteristics Predicting Its Visualization

Ranjan

Boutet

et al. 2018

Stereotact Funct Neurosurg

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“…A recent study demonstrated that PD-MCI patients who progressed to dementia already showed greater white matter hyperintensities at baseline, compared to PD-MCI patients who did not progress to dementia [13]. A previous study comparing patients with PD and healthy controls, demonstrated that despite absence of differences in age, cognitive scores, and global GM volume, PD patients had lower global WM [14]. Similarly, a recent cross-sectional study showed that compared to healthy controls and PD patients without cognitive symptoms, PD-MCI patients showed more distributed WM abnormalities in anterior and posterior parts of the brain (e.g., the corona radiata and the uncinated fasciculus) [15].…”

Section: Introductionmentioning

confidence: 93%

Longitudinal brain volumetric changes and their predictive effects on cognition among cognitively asymptomatic patients with Parkinson's disease

Wen

Chander

et al. 2015

Parkinsonism & Related Disorders

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“…Messina et al [27] found spared caudate volume in PD, multiple system atrophy with PD, and progressive supranuclear palsy. Shrinkage of the putamen and pallidum was a more sensitive anatomical marker of neurodegeneration than that of the caudate nucleus [27,28,29,30,31]. …”

Section: Discussionmentioning

confidence: 99%

Delay Discounting of Reward and Caudate Nucleus Volume in Individuals with α-Synuclein Gene Duplication before and after the Development of Parkinson’s Disease

Szamosi¹,

Nagy

Kéri

2012

Neurodegener Dis

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Background/Aims: α-Synuclein (SNCA) may be a key factor in dopaminergic neurotransmission, reward processing, and neurodegeneration in Parkinson’s disease (PD). We investigated delay discounting of reward and caudate volume in SNCA gene duplication carriers before and after the development of PD. Methods: Participants were 7 presymptomatic SNCA duplication carriers who later developed PD (follow-up period: 5.4 years) and 10 matched non-carrier controls. At the follow-up assessment, patients received levodopa (l-DOPA) therapy. Delay discounting of reward was assessed with the Kirby discounting questionnaire. We measured the volume of the caudate nucleus and cerebral cortex using structural MRI and FreeSurfer software. Results: In the presymptomatic stage, carriers showed similar delay discounting and caudate volume to that of non-carrier controls. However, after the development of PD, we observed a significant elevation in delay discounting (impulsive decisions) and reduced caudate volume. There was no cortical atrophy. Conclusion: Impaired reward-related decision making and caudate volume loss are not detectable in the presymptomatic stage in SNCA duplication carriers. These behavioral and neuroanatomical alterations are observed after the development of clinical symptoms when there is extensive neurodegeneration. Study limitations include a small sample size as well as the potential confounding effect of general cognitive decline.

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Regional Volume Analysis of the Parkinson Disease Brain in Early Disease Stage: Gray Matter, White Matter, Striatum, and Thalamus

Cited by 71 publications

References 44 publications

Subthalamic Nucleus Visualization on Routine Clinical Preoperative MRI Scans: A Retrospective Study of Clinical and Image Characteristics Predicting Its Visualization

Subthalamic Nucleus Visualization on Routine Clinical Preoperative MRI Scans: A Retrospective Study of Clinical and Image Characteristics Predicting Its Visualization

Longitudinal brain volumetric changes and their predictive effects on cognition among cognitively asymptomatic patients with Parkinson's disease

Delay Discounting of Reward and Caudate Nucleus Volume in Individuals with α-Synuclein Gene Duplication before and after the Development of Parkinson’s Disease

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