Regional venous drainage of the human heart.

Hood, William B.

doi:10.1136/hrt.30.1.105

Cited by 123 publications

(45 citation statements)

References 4 publications

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“…In addition, the coronary sinus does not receive venous blood from the entire myocardium, detailed studies of coronary venous anatomy (Hood, 1968) having shown that coronary sinus flow consists of venous effluent blood from nearly all of the left ventricle, plus a contribution from the right ventricle, amounting to 85% of total flow through the coronary arteries (Gensini, 1965). Coronary sinus flow does, however, closely follow total myocardial flow in response to interventions and may justifiably be combined with coronary arterio-venous content data to estimate predominantly left ventricular myocardial pharmacokinetics.…”

Section: Discussionmentioning

confidence: 99%

Relationship between myocardial uptake and actions in heart failure of methyldigoxin.

Hayward¹,

Greenwood²,

Stephens³

et al. 1983

Brit J Clinical Pharma

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1 Problems have been encountered in recent years in confirming useful benefit to patients with heart failure and sinus rhythm from acute exposure to digitalis glycosides, though effectiveness of these preparations upon cardiac contractile performance is indisputable. Undesired effects such as those upon systemic vascular resistance have been invoked to explain this. 2 Detailed haemodynamic responses have been studied by cardiac catheterisation in nine such patients for 30 min after intravenous methyldigoxin infusion. Myocardial glycoside uptake was simultaneously assessed. 3 Methyldigoxin uptake by the heart was rapid, passing its peak within 20 min, and was followed by substantial elution. 4 A small progressive and significant increase in cardiac output was observed, though left ventricular filling pressures were not significantly reduced after methyldigoxin. Cardiac contractile function as assessed by left ventricular maximum dP/dt, measured in six patients, showed consistent improvement.

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Section: Discussionmentioning

confidence: 99%

Relationship between myocardial uptake and actions in heart failure of methyldigoxin.

Hayward¹,

Greenwood²,

Stephens³

et al. 1983

Brit J Clinical Pharma

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show abstract

“…It has been reported that almost ninety-five percent of the coronary sinus blood comes from the perfusion area of the left coronary artery in dog (Hammond and Austen 1967;Tamura et al 1969). In the study of postmortem human heart, Hood (1968) …”

Section: Discussionmentioning

confidence: 99%

A continuous and quantitative analysis of the uneven distribution of myocardial blood flow in dogs using a distribution function of the clearance time constant.

Ashikawa

Ino-Oka

Kitaoka

et al. 1982

Tohoku J. Exp. Med.

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“…Systemic, pulmonary artery and coronary sinus pressures were measured using Bell and Howell transducers. Coronary sinus flow, which has been shown to represent left ventricular myocardial blood flow (Hood, 1968) was determined using the continuous thermodilution technique of Ganz, Tamrura, Marcus, Donoso, Yoshida & Swan (1971). These authors showed close agreement between this and other methods of measuring myocardial blood flow.…”

Section: Rimiterol Studymentioning

confidence: 99%

Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline.

Stephens¹,

Hayward²,

Ead³

et al. 1978

Brit J Clinical Pharma

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I Rimiterol and isoprenaline produced significant dose-related increases in cardiac output. 2 These changes in cardiac output were accompanied by increases in heart rate and myocardial oxygen consumption which were similar for each drug and dose-related. 3 Isoprenaline in contrast with rimiterol produced direct coronary vasodilation, i.e. coronary vasodilation in excess of that required to meet increases in myocardial oxygen demands.4 It is suggested that the P-adrenergic receptors in the human coronary vasculature are mainly of the /5, type.

show abstract

Regional venous drainage of the human heart.

Cited by 123 publications

References 4 publications

Relationship between myocardial uptake and actions in heart failure of methyldigoxin.

Relationship between myocardial uptake and actions in heart failure of methyldigoxin.

A continuous and quantitative analysis of the uneven distribution of myocardial blood flow in dogs using a distribution function of the clearance time constant.

Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline.

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