Regional variations in the intra- and intervertebral trabecular microarchitecture of the osteoporotic axial skeleton

Schröder, G.; Baginski, Anna Maria; Schulze, M.; Hiepe, Laura; Bugaichuk, Semjon; Martin, H.; Andresen, Julian Ramin; Moritz, Mario; Andresen, Reimer; Schober, Hans-Christof

doi:10.1007/s12565-023-00726-6

Cited by 3 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Typical locations are the thoracic vertebrae 7, 8, and 12, and the lumbar vertebrae 1 and 2 [22,23]. The fractures were typically in the thoracolumbar and lumbar portions of the spine [22,23]. In the present case, we found an increase in the density of cancellous bone between TV 5 and TV 8.…”

Section: Discussionsupporting

confidence: 52%

See 1 more Smart Citation

Diffuse idiopathic skeletal hyperostosis in an 83-year-old female body donor with osteoporosis – protection or risk for the occurrence of insufficiency fractures of the spine?

Schröder,

Götz,

Kruse

et al. 2023

Osteologie

Self Cite

View full text Add to dashboard Cite

Zusammenfassung Einleitung Die vorliegende Studie hatte das Ziel, Erkenntnisse über Veränderungen in der Knochendichte und der kortikale Dicke bei Patienten mit diffuser idiopathischer skelettaler Hyperostose (DISH) und Osteoporose zu gewinnen, um das Verständnis für Risikobereiche für das Auftreten von Insuffizienzfrakturen am Achsenskelett zu verbessern. Fallbeschreibung und Ergebnisse Eine weibliche 83-Jährige Körperspenderin mit DISH und Osteoporose wurde mittels CT/QCT- sowie Mikro-CT-Bildgebung untersucht. Die kortikale Dicke wurde an den Endplatten und der kortikalen Schale von 15 Wirbelkörpern an 1800 Messpunkten ermittelt, um Unterschiede zwischen den Wirbelsäulen Abschnitten festzustellen. Alle erhobenen Daten wurden mit dem Softwarepaket SPSS, Version 24.0 (Armonk, New York: IBM Corp., USA) analysiert. Es zeigte sich eine signifikant höhere kortikale Dicke in der Brustwirbelsäule im Vergleich zur Hals- (p=0,001) und Lendenwirbelsäule (p<0,001). Die Kortikalisdicke ist an der Hinterkante in den verschiedenen Abschnitten am geringsten ausgeprägt. Der spongiöse Knochenmineralgehalt steigt in den von DISH betroffenen Wirbelkörpern an. Obwohl die Halswirbelsäule nicht von DISH betroffen war, fand sich dort die höchste Knochendichte der gesamten Wirbelsäule. Schlussfolgerungen Die signifikant höhere kortikale Dicke und der erhöhte spongiöse Knochenmineralgehalt in der Brustwirbelsäule bei DISH könnte auf eine erhöhte Stabilität und ein geringeres Frakturrisiko in diesem Bereich hinweisen. Die hohe Knochendichte im HWS-Bereich scheint auch bei vorliegender Osteoporose am Achsenskelett einen kritischen Frakturschwellenwert nicht zu unterschreiten.

show abstract

Section: Discussionsupporting

confidence: 52%

“…Fracture rates increase especially beyond the age of 70 years [21]. Typical locations are the thoracic vertebrae 7, 8, and 12, and the lumbar vertebrae 1 and 2 [22,23]. The fractures were typically in the thoracolumbar and lumbar portions of the spine [22,23].…”

Section: Discussionmentioning

confidence: 99%

Diffuse idiopathic skeletal hyperostosis in an 83-year-old female body donor with osteoporosis – protection or risk for the occurrence of insufficiency fractures of the spine?

Schröder,

Götz,

Kruse

et al. 2023

Osteologie

Self Cite

View full text Add to dashboard Cite

show abstract

“…In a recent investigation, Schröder et al [ 15 ] studied cancellous bone cylinders from 3 quadrants of 11 body donors aged 79.1 years on average. The authors performed punctures on 242 vertebrae in the ventrodorsal direction and extracted 726 cancellous bone cylinders.…”

Section: Discussionmentioning

confidence: 99%

“…In the intravertebral aspect, the authors found no significant differences in DA. For VD puncture, Schröder et al [ 15 ] also reported lower DA values in the central quadrant compared to those in the marginal areas. The higher DA of men compared to women in the CC group agrees with the lower connectivity registered in men.…”

Section: Discussionmentioning

confidence: 99%

Regional Variations in the Intra- and Intervertebral Trabecular Microarchitecture of the Osteoporotic Axial Skeleton with Reference to the Direction of Puncture

Schröder,

Mittlmeier,

Gahr

et al. 2024

Diagnostics

Self Cite

View full text Add to dashboard Cite

Background: Trabeculae in vertebral bodies are unequally distributed within the cervical spine (CS), the thoracic spine (TS), and lumbar spine (LS). Such structures are also unequally distributed within the individual vertebrae. Exact knowledge of the microstructure of these entities could impact our understanding and treatment of fractures caused by osteoporosis and possibly improve surgical approaches. Appropriate investigations could help clarify the pathomechanisms of different forms of osteoporotic vertebral fractures, as well as different changes in morphological findings like the trabecular bone score (TBS). In the present study, we applied punctures to the craniocaudal and ventrocaudal directions and obtained cylinders of cancellous bone from the central portions and marginal regions of cervical vertebrae 5 and 6, thoracic vertebrae 8 and 12, and lumbar vertebrae 1 and 3. We systematically analyzed these samples to determine the bone volume fraction, trabecular thickness, separation, connectivity density, degree of anisotropy, and structure model index. Methods: Using an 8-gauge Jamshidi needle, we obtained samples from three quadrants (Q I: right margin; Q II: central; Q III: left margin) in the frontal and transverse plane and prepared these samples with a moist cloth in a 1.5 mL Eppendorf reaction vessel. The investigations were performed on a micro-CT device (SKYSCAN 1172, RJL Micro & Analytic Company, Karlsdorf-Neuthard, Germany). All collected data were analyzed using the statistical software package SPSS (version 24.0, IBM Corp., Armonk, NY, USA). Student’s t test, the Wilcoxon–Mann–Whitney test, the Chi-squared test, and univariate analysis were used for between-group comparisons. The selection of the test depended on the number of investigated groups and the result of the Shapiro–Wilk test of normal distribution. In the case of statistically significant results, a post hoc LSD test was performed. Results: In total, we obtained 360 bone samples from 20 body donors. The craniocaudal puncture yielded data of similar magnitudes for all investigated parameters in all three quadrants, with the highest values observed in the CS. Comparisons of the ventrodorsal and craniocaudal microstructure revealed a significantly lower trabecular density and a significantly higher degree of anisotropy in the craniocaudal direction. Conclusions: The results presented different distributions and behaviors of trabecular density, with lower density in the mid-vertebral region over the entire breadth of the vertebrae. Reduced trabecular density caused a higher degree of anisotropy and was, therefore, associated with a lower capacity to sustain biomechanical loads. Fractures in fish vertebrae were easily explained by this phenomenon. The different changes in these structures could be responsible, in part, for the changes in the TBS determined using dual-energy X-ray absorptiometry. These results confirm the clinical relevance of the TBS.

show abstract

Interobserver variability in the determination of bone mineral density in Hounsfield units from differently configured fields of measurement in the cancellous bone of vertebral bodies from elderly body donors

Schröder,

Andresen,

Hiepe

et al. 2024

Journal of Orthopaedics

View full text Add to dashboard Cite

Regional variations in the intra- and intervertebral trabecular microarchitecture of the osteoporotic axial skeleton

Cited by 3 publications

References 40 publications

Diffuse idiopathic skeletal hyperostosis in an 83-year-old female body donor with osteoporosis – protection or risk for the occurrence of insufficiency fractures of the spine?

Diffuse idiopathic skeletal hyperostosis in an 83-year-old female body donor with osteoporosis – protection or risk for the occurrence of insufficiency fractures of the spine?

Regional Variations in the Intra- and Intervertebral Trabecular Microarchitecture of the Osteoporotic Axial Skeleton with Reference to the Direction of Puncture

Interobserver variability in the determination of bone mineral density in Hounsfield units from differently configured fields of measurement in the cancellous bone of vertebral bodies from elderly body donors

Contact Info

Product

Resources

About