Regional variations in microstructural properties of vertebral trabeculae with aging

Gong, He; Zhang, Ming; Yeung, H.Y.; Qin, Ling

doi:10.1007/s00774-004-0557-4

Cited by 83 publications

(70 citation statements)

References 29 publications

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“…First, previous work on humans indicates that trabecular architecture varies across and within vertebral bodies (Gong et al, 2005;Chen et al, 2008). Regional variation has never been investigated in strepsirhine primate vertebral bodies.…”

Section: Methodsmentioning

confidence: 99%

Lumbar Vertebral Body Bone Microstructural Scaling in Small to Medium‐Sized Strepsirhines

Fajardo

DeSilva

Manoharan

et al. 2013

The Anatomical Record

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Bone mass, architecture, and tissue mineral density contribute to bone strength. As body mass (BM) increases any one or combination of these properties could change to maintain structural integrity. To better understand the structural origins of vertebral fragility and gain insight into the mechanisms that govern bone adaptation, we conducted an integrative analysis of bone mass and microarchitecture in the last lumbar vertebral body from nine strepsirhine species, ranging in size from 42 g (Microcebus rufus) to 2,440 g (Eulemur macaco). Bone mass and architecture were assessed via mCT for the whole body and spherical volumes of interest (VOI). Allometric equations were estimated and compared with predictions for geometric scaling, assuming axial compression as the dominant loading regime. Bone mass, microarchitectural, and vertebral body geometric variables predominantly scaled isometrically. Among structural variables, the degree of anisotropy (Tb.DA) was the only parameter independent of BM and other trabecular architectural variables. Tb.DA was related to positional behavior. Orthograde primates had higher average Tb.DA (1.60) and more craniocaudally oriented trabeculae while lorisines had the lowest Tb.DA (1.25), as well as variably oriented trabeculae. Finally, lorisines had the highest ratio of trabecular bone volume to cortical shell volume ($3x) and while there appears to be flexibility in this ratio, the total bone volume (trabecular þ cortical) scales isometrically (BM 1.23 , r 2 ¼ 0.93) and appears tightly constrained. The common pattern of isometry in our measurements leaves open the question of how vertebral bodies in strepsirhine species compensate for increased BM. Anat Rec,

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Section: Methodsmentioning

confidence: 99%

Lumbar Vertebral Body Bone Microstructural Scaling in Small to Medium‐Sized Strepsirhines

Fajardo

DeSilva

Manoharan

et al. 2013

The Anatomical Record

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“…The regional variation of vertebral microstructure has been examined extensively [23][24][25] . We studied 3D microstructure of L4 from Japanese cadaver donors by quantitative micro-CT and electron microscopic methods [25] .…”

Section: Vertebramentioning

confidence: 99%

“…There was no significant decline of Tb.Th with advancing age. Thus, age-related decrease of BV/ TV is mainly related to increased Tb.Sp and decreased Tb.N [17,23,25] . Cancellous bone of vertebra is complicated morphologically that contains numerous plate-like and rod-like trabeculae [24][25][26][27] .…”

Section: Vertebramentioning

confidence: 99%

Bone three-dimensional microstructural features of the common osteoporotic fracture sites

Chen

Kubo

2014

WJO

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Osteoporosis is a common metabolic skeletal disorder characterized by decreased bone mass and deteriorated bone structure, leading to increased susceptibility to fractures. With aging population, osteoporotic fractures are of global health and socioeconomic importance. The three-dimensional microstructural information of the common osteoporosis-related fracture sites, including vertebra, femoral neck and distal radius, is a key for fully understanding osteoporosis pathogenesis and predicting the fracture risk. Low vertebral bone mineral density (BMD) is correlated with increased fracture of the spine. Vertebral BMD decreases from cervical to lumbar spine, with the lowest BMD at the third lumbar vertebra. Trabecular bone mass of the vertebrae is much lower than that of the peripheral bone. Cancellous bone of the vertebral body has a complex heterogeneous three-dimensional microstructure, with lower bone volume in the central and anterior superior regions. Trabecular bone quality is a key element to maintain the vertebral strength. The increased fragility of osteoporotic femoral neck is attributed to low cancellous bone volume and high compact porosity. Compared with age-matched controls, increased cortical porosity is observed at the femoral neck in osteoporotic fracture patients. Distal radius demonstrates spatial inhomogeneous characteristic in cortical microstructure. The medial region of the distal radius displays the highest cortical porosity compared with the lateral, anterior and posterior regions. Bone strength of the distal radius is mainly determined by cortical porosity, which deteriorates with advancing age. Key words: Osteoporosis; Fracture; Microstructure; Trabecular bone; Cortical bone; Vertebra; Femoral neck; Distal radius Core tip: The most common sites of the osteoporotic fractures include the vertebra, femoral neck and distal radius, where the microstructural information is a key for fully understanding osteoporosis pathogenesis and improving the prediction of fracture risk. Vertebral strength is mostly preserved by trabecular bone, which is microstructurally inhomogeneous, with lower bone volume in the central and anterior superior regions. Increased fragility of osteoporotic femoral neck is attributed to low cancellous bone volume and high compact porosity. Distal radius shows significant variations in cortical porosity, which is the major element attributed to bone strength of the distal radius.

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“…The higher stresses generated also could be relate to an agefactor which is in agreement with the previous study [1]. In that particular study, it had shown that the elderly population tended to produce higher von-Mises stress than the middle age and young age population by 50% and 120%, respectively.The loss of bone strength and structural change due to aging effect is mainly characterized by a decrease in bone volume fraction, a shift from plate-like trabeculaeto more rod-like microstructures, as well as a decrease in connectivity density combined with anincrease in orientation of trabeculae along the main axis of loading [42] - [44], which can be partiallyexplained by adaptive remodeling [45]. Fig.…”

Section: Resultsmentioning

confidence: 99%

Finite Element Analysis of Osteoporotic Vertebrae with First Lumbar (L1) Vertebral Compression Fracture

Mazlan¹,

Todo²,

Takano³

et al. 2014

IJAPM

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Abstract-The aim of this work is to assess the biomechanical response or load transfer response between osteoporotic (with first lumbar (L1) vertebral compression fracture) and healthy vertebrae in five vertebral physiological motions namely as compression, flexion, extension, lateral bending and axial rotation. For this purpose, an image-basedheterogeneous three-dimensional patient-specific of lumbar and thoracic spinal unit (T12-L2) finite element models for healthy and osteoporotic subjects were created.The finite element analysis have shown that one of the most significant effects of osteoporosis is the tendency to produce higher stress and strain in the cancellous region of the vertebral body. The maximum stress and strain was 4.53 fold (compression) and 5.43 fold (axial rotation) higher for the osteoporotic than the healthy subject, respectively, under the similar loading activity. Uneven stress distribution patterns also have been detected in the osteoporotic vertebrae rather than the healthy vertebrae. All of these characteristicsare reflected bya reduced structural strength and bone mass which might lead to an increased risk of fracture. These results strengthen the paradigm of a strong relationship between osteoporosis and its high susceptibility to fracture.Index Terms-Biomechanics, finite element analysis, osteoporosis, vertebrae. I. INTRODUCTIONOsteoporosis is the most common disease affecting both men and women [1], and it is becoming increasingly prevalent in aging society [2]. Itsclinical significance lies in the high vulnerability and susceptibility to bone fracture [3]. It is characterized by low bone mass and micro-architectural deterioration of bone tissue [4]. Even though osteoporotic fractures can occur anywhere in the human body [5], the most prevalent fracture site is the spine [6], particularly in the elderly population [3]. In Japan, there are more than 10 million osteoporosis patients [7]. It is believed that this number will significantly increase in relation to Japan"s life expectancy continues to rise. In the United States, about 1.5 million fractures due to osteoporosis are reported annually including over 700,000 vertebral fractures with high mortality rates. It was reported that, the survival rate was 72% after one year the symptom was first detected and this figure was then drastically reduced to only 28% after five years. Therefore, early detection of osteoporotic disease play a Manuscript received May 14, 2014; revised July 14, 2014. M. H. Mazlan is with Kyushu University, Japan (e-mail: hazli.010@s.kyushu-u.ac.jp).M. Todo is with the Research Institute for Applied Mechanics, Kyushu University, Japan (e-mail: todo@riam.kyushu-u.ac.jp).Hiromitsu Takano and Ikuho Yonezawa are with the Department of Orthopedic Surgery, Juntendo University School of Medicine, Japan (e-mail: hrtakano@juntendo.ac.jp).significant role in order to improve the health quality of the community and to organize early treatment as preventive and precautionary measures.Human spine is consisted of 24 spinal ...

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Regional variations in microstructural properties of vertebral trabeculae with aging

Cited by 83 publications

References 29 publications

Lumbar Vertebral Body Bone Microstructural Scaling in Small to Medium‐Sized Strepsirhines

Lumbar Vertebral Body Bone Microstructural Scaling in Small to Medium‐Sized Strepsirhines

Bone three-dimensional microstructural features of the common osteoporotic fracture sites

Finite Element Analysis of Osteoporotic Vertebrae with First Lumbar (L1) Vertebral Compression Fracture

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