Regional variation in vertebral bone morphology and its contribution to vertebral fracture strength

Novel methodology for assessing biomaterial–biofluid interaction in cancellous bone

“…This is crucial to reduce the inconsistency, render the experiments reproducible and shift the focus onto understanding the influence of viscosity and structure on the flow behaviour. The pore spacing of the Osteo surrogates (0.89 ± 0.03 mm) was comparable to that reported in the literature for human osteoporotic vertebral cancellous bone [23][24][25][26][27], suggesting that the surrogates were pathologically representative. The boundary of the surrogates simulated the vertebral shell which confines the flow and controls the intravertebral pressure, significantly affecting the filling pattern [28].…”

Intermediate strain rate behaviour of cancellous bone: Links between microstructural and mechanical properties

“…The higher ultimate stress value from the femoral head location versus the values from the great trochanter location also supports the anatomic hypothesis regarding the real loading [22]. Mechanical parameters were consistent between the six bones with a maximum Kruskal-Wallis p-value of 0.54 for σ y .…”

Differences in endplate deformation of the adjacent and augmented vertebra following cement augmentation

“…Experimental analysis is equally varied. Berlemann et al, found FSU strength to be 19% lower after intact augmentation, although the experiment was performed with matched specimens, there was no control for vertebral size or disc health, two factors which will influence fracture strength [17]. Kayanja et al [23], using multi-segmental cadaveric specimens, concluded that adjacent vertebral mechanics were not significantly altered following cement augmentation.…”