Regional variation in myocardial accumulation of 18 F-fluorodeoxyglucose in fasted normal subjects

Additional Heparin Preadministration Improves Cardiac Glucose Metabolism Suppression over Low-Carbohydrate Diet Alone in 18F-FDG PET Imaging

“…Our findings on analyzing the patterns of 18 F-FDG distribution in physiologically nondiffuse cardiac uptake (score of 3) are in keeping with earlier publications (22)(23)(24). Knowledge of these variable patterns of nonpathologic uptake is important in the interpretation of 18 F-FDG PET scans for cardiac inflammatory or infectious disease when cardiac suppression may not be adequate.…”

Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart

“…Our observations that the dietary status of the animal influences bicarbonate production from 13 C pyruvate agrees with previous data demonstrated by Schroeder et al in small animals (4). Similarly, in human cardiac metabolic studies using 18 FDG PET and SPECT, spatial heterogeneity in uptake has been observed in the fasted state (19)(20)(21). Oral glucose loading as well as hyperinsulinemic-euglycemic clamping have been suggested as methods to improve homogeneity of uptake in the myocardium.…”

Metabolic responses of hibernating and infarcted myocardium to revascularization. A follow-up study of regional perfusion, function, and metabolism.

“…Although cell death may take some hours to occur after an ischemic event, the onset of morphological changes occurs at an earlier stage and is characterized initially by membrane damage.27 Cellular degeneration, involving the replacement of myofibrils by mitochondria, sarcoplasmic reticulum, and glycogen granules,28 30 Despite the use of a fasting FDG protocol, we believe, for two reasons, that the hot spots reflect persistent abnormal metabolism rather than heterogeneity of the metabolic response. 25 First, the locations of these sites are dispersed through all regions of the myocardium, in contrast to the usual posterolateral site of false-positive findings. Second, the prevalence of false-positives with fasting, postexercise FDG imaging is lower than that reported for resting imaging.…”