Regional sympathetic innervation of the heart by means of metaiodobenzylguanidine imaging in silent ischemia

Shakespeare, Carl; Page, C. J.; O’Doherty, Michael; Nunan, T. O.; Cooper, Ian; Katritsis, D.; Coltart, D J; Webb-Peploe, M M

doi:10.1016/0002-8703(93)90749-y

Cited by 10 publications

(3 citation statements)

References 27 publications

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“…11 An experimental study using a canine model confirmed that MIBG uptake accurately indicates the presence or absence of myocardial sympathetic innervation established by neuroelectrophysiological testing. 17 Complete disappearance of MIBG uptake indicates the global denervation of the ventricle. Because myocardial infarction or contractile failure was not observed in our subjects early after ASO, ischemic myocardial injury associated with the surgery is unlikely to be the reason for the absent MIBG uptake after ASO.…”

Section: Possible Pathogenesis Of Absent Mibg Uptake After Asomentioning

confidence: 99%

Sympathetic Denervation and Reinnervation After Arterial Switch Operation for Complete Transposition

et al. 1998

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Section: Possible Pathogenesis Of Absent Mibg Uptake After Asomentioning

confidence: 99%

Sympathetic Denervation and Reinnervation After Arterial Switch Operation for Complete Transposition

et al. 1998

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“…Normally, however, no detectable uptake of MIBG is found in bone or bone marrow (13). The normal accumulation of MIBG in the myocardium may in the future be used to assess the degree of innervation of the heart, especially in patients with heart diseases, e.g., ischemic disease (14,15). Neuroblastoma is a serious disease.…”

Section: Discussionmentioning

confidence: 99%

The Impact of¹²³I-Meta-Iodobenzylguanidine Scintigraphy on Diagnostics and Follow-up of Neuroblastoma

et al. 1995

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“…Regional cardiac [123I]-MIBG uptake can be quantitated relative to the highest uptake in the myocardium in both planar and tomographic images [12,13]. Regional cardiac [123I]-MIBG uptake can be quantitated relative to the highest uptake in the myocardium in both planar and tomographic images [12,13].…”

Section: Quantitation Of Cardiac [1231]-mibg Uptakementioning

confidence: 99%

Neuronal dysfunction in heart failure assessed by cardiac 123-iodine metaiodobenzylguanidine scintigraphy

et al. 1996

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In patients with chronic heart failure, increased sympathetic activity and cardiac sympathetic neuronal dysfunction are present and have been related to unfavourable clinical outcome. Modification of these alterations with the objective to improve prognosis has become an important aim of pharmacological therapy for these patients. A noninvasive technique to assess sympathetic neuronal function at the cardiac level may be valuable in evaluating newly developed therapeutic strategies. 123-iodine metaiodobenzylguanidine can be used to visualize cardiac sympathetic nerve function and activity. Single photon emission computerized tomographic is preferred to planar scintigraphy since it does not depend on superposition of other anatomical structures and may allow assessment of regional cardiac 123-iodine metaiodobenzylguanidine uptake. Although the quantitation of cardiac uptake in these tomographic images has several limitations, the use of the left ventricular cavity as a reference, calibrated by the 123-iodine activity in a blood sample drawn at the time of acquisition, may have clinical applications, with respect to the evaluation of therapeutical intervention in patients with heart failure.

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Regional sympathetic innervation of the heart by means of metaiodobenzylguanidine imaging in silent ischemia

Cited by 10 publications

References 27 publications

Sympathetic Denervation and Reinnervation After Arterial Switch Operation for Complete Transposition

Sympathetic Denervation and Reinnervation After Arterial Switch Operation for Complete Transposition

The Impact of¹²³I-Meta-Iodobenzylguanidine Scintigraphy on Diagnostics and Follow-up of Neuroblastoma

Neuronal dysfunction in heart failure assessed by cardiac 123-iodine metaiodobenzylguanidine scintigraphy

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Regional sympathetic innervation of the heart by means of metaiodobenzylguanidine imaging in silent ischemia

Cited by 10 publications

References 27 publications

Sympathetic Denervation and Reinnervation After Arterial Switch Operation for Complete Transposition

Sympathetic Denervation and Reinnervation After Arterial Switch Operation for Complete Transposition

The Impact of123I-Meta-Iodobenzylguanidine Scintigraphy on Diagnostics and Follow-up of Neuroblastoma

Neuronal dysfunction in heart failure assessed by cardiac 123-iodine metaiodobenzylguanidine scintigraphy

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The Impact of¹²³I-Meta-Iodobenzylguanidine Scintigraphy on Diagnostics and Follow-up of Neuroblastoma