Regional Specificity of Brain Atrophy in Huntington's Disease

Halliday, Glenda M.; McRitchie, D.A.; Macdonald, Virginia; Double, Kay L.; Trent, Ronald J.; McCusker, Elizabeth

doi:10.1006/exnr.1998.6919

Cited by 235 publications

(154 citation statements)

References 50 publications

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“…The following 2 elements make us confident that the decrease of the cerebral cortical MT ratio in our HD gene carriers reflects microstructural damage rather than volume loss: 1) The in-house-developed software and the conservative parameters we chose for its application should have virtually eliminated the possibility of partial volume effects at the GM, WM, and CFS interfaces. 2) In the HD carriers, we observed a leftward bias of loss of volume of the cerebral cortex, confirming previous findings, 28,29 whereas the MT ratio values in the cerebral cortex were essentially symmetric.…”

Section: Discussionsupporting

confidence: 89%

“…13 Second, it confirms the capability of MT imaging to reveal microstructural changes in the remaining cortical GM in neurodegenerative diseases of the CNS. 14,15 The diffuse distribution of cortical cerebral atrophy in our sample of HD carriers with a range of clinical severity is expected on the basis of the neuropathologic 29 and MR imaging findings, 30,31 which indicate that early or more severe cortical changes are observed in the occipital regions from which, with disease progression, they proceed forward with sparing of the medial temporal lobes and most of the anterior and limbic portions of the frontal lobes.…”

Section: Discussionmentioning

confidence: 69%

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Magnetization Transfer MR Imaging Demonstrates Degeneration of the Subcortical and Cortical Gray Matter in Huntington Disease

Ginestroni¹,

Battaglini²,

Diciotti³

et al. 2010

AJNR Am J Neuroradiol

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 69%

Magnetization Transfer MR Imaging Demonstrates Degeneration of the Subcortical and Cortical Gray Matter in Huntington Disease

Ginestroni¹,

Battaglini²,

Diciotti³

et al. 2010

AJNR Am J Neuroradiol

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“…Subject information, including history of disease, is shown in Table 2. Both AD and HD are known to cause changes in cortical thickness (Frisoni, 1996;De Leon et al, 1997;Jack et al, 1997;Vonsattel and DiFiglia, 1998;Halliday et al, 1998), but no study has demonstrated a change in the location of area boundaries due to these diseases. A discussion of the effect of including individuals with history of neurological disease is located in the Supplementary Materials.…”

Section: B)mentioning

confidence: 99%

Accurate prediction of V1 location from cortical folds in a surface coordinate system

et al. 2008

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Previous studies demonstrated substantial variability of the location of primary visual cortex (V1) in stereotaxic coordinates when linear volume-based registration is used to match volumetric image intensities (Amunts et al., 2000). However, other qualitative reports of V1 location (Smith, 1904;Stensaas et al., 1974;Rademacher et al., 1993) suggested a consistent relationship between V1 and the surrounding cortical folds. Here, the relationship between folds and the location of V1 is quantified using surface-based analysis to generate a probabilistic atlas of human V1. High-resolution (about 200 μm) magnetic resonance imaging (MRI) at 7 T of ex vivo human cerebral hemispheres allowed identification of the full area via the stria of Gennari: a myeloarchitectonic feature specific to V1. Separate, whole-brain scans were acquired using MRI at 1.5 T to allow segmentation and mesh reconstruction of the cortical gray matter. For each individual, V1 was manually identified in the high-resolution volume and projected onto the cortical surface. Surface-based intersubject registration (Fischl et al., 1999b) was performed to align the primary cortical folds of individual hemispheres to those of a reference template representing the average folding pattern. An atlas of V1 location was constructed by computing the probability of V1 inclusion for each cortical location in the template space. This probabilistic atlas of V1 exhibits low prediction error compared to previous V1 probabilistic atlases built in volumetric coordinates. The increased predictability observed under surface-based registration suggests that the location of V1 is more accurately predicted by the cortical folds than by the shape of the brain embedded in the volume of the skull. In addition, the high quality of this atlas provides direct evidence that surface-based intersubject registration methods are superior to volume-based methods at superimposing functional areas of cortex, and therefore are better suited to support multi-subject averaging for functional imaging experiments targeting the cerebral cortex.

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“…Psychiatric manifestations occur more frequently in HD than other dementias and basal ganglia disorders, and often resemble schizophrenia, bipolar, and unipolar syndromes, obsessive-compulsive disorder, or their variants (Anderson et al, 2001;Folstein and Folstein, 1983;Mendez, 1994). HD causes progressive atrophy and neuronal loss in cortical-striatal circuits corresponding to a progressive triad of motor, cognitive, and psychiatric symptoms (Cummings, 1993;Halliday et al, 1998;Joel, 2001;Litvan et al, 1998;Paulsen et al, 2001;Thieben et al, 2002;Vonsattel et al, 1985)]. …”

Section: Introductionmentioning

confidence: 99%

Huntington disease as a dual diagnosis disorder: Data from the national research roster for Huntington disease patients and families

Ehret

Day

Wiegand

et al. 2007

Drug and Alcohol Dependence

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Although an extensive literature characterizes a linkage between primary mental illnesses and substance use disorders, a paucity of research exists concerning dual diagnosis phenomena in Huntington disease (HD). Data from the National Research Roster on HD suggest that higher levels of alcohol and cigarette use are associated with greater ratings of psychiatric symptoms and a younger age of HD symptom onset, and that progressive alcohol use after HD symptom onset is linked with worsening psychiatric symptom progression. These findings suggest HD entails dual diagnosis phenomena similar to that identified in patients with primary psychiatric disorders.

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Regional Specificity of Brain Atrophy in Huntington's Disease

Cited by 235 publications

References 50 publications

Magnetization Transfer MR Imaging Demonstrates Degeneration of the Subcortical and Cortical Gray Matter in Huntington Disease

Magnetization Transfer MR Imaging Demonstrates Degeneration of the Subcortical and Cortical Gray Matter in Huntington Disease

Accurate prediction of V1 location from cortical folds in a surface coordinate system

Huntington disease as a dual diagnosis disorder: Data from the national research roster for Huntington disease patients and families

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