Regional Specific Changes in Glutamate and GABAA Receptors, PKC Isozymes, and Ionic Channels in Kindling Epileptogenesis of the Hippocampus of the Rat

Silva, Fernando H. Lopes da; Faas, Guido C.; Kamphuis, Willem; Titulaer, M.N.G.; Vreugdenhil, Martin; Wadman, Wytse J.

doi:10.1007/978-1-4615-5375-5_17

Cited by 2 publications

(4 citation statements)

References 42 publications

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“…We found that episodic exposure to elevated CORT levels during a critical phase of epileptogenesis (McNamara 1986;Lopes da Silva et al . 1998) accelerates the onset of behavioural symptoms of epilepsy.…”

Section: Discussionmentioning

confidence: 99%

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Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long‐term changes in hippocampal CA1 cells, in the fully kindled state

Karst

Kloet

Joëls

1999

Eur J of Neuroscience

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We tested the effect of episodic (approximately 10 days) corticosterone treatment on: (i) behavioural symptoms during kindling epileptogenesis; and (ii) electrical activity in the CA1 hippocampal area during epileptogenesis, and later on, in the fully kindled state. Male rats received a corticosterone-releasing pellet (100 mg/day) shortly before kindling was started, resulting in elevated hormone levels during the early and middle stages of epileptogenesis. The appearance of moderate behavioural signs of epilepsy and severe tonic-clonic seizures was significantly accelerated in corticosterone-treated animals compared to placebo controls. During epileptogenesis, corticosterone treatment did not affect the amplitude and paired-pulse characteristics of in vivo-recorded CA1 field responses, or the duration of the afterdischarge following tetanic stimulation of the Schaffer collaterals. However, other properties of CA1 cells studied in vitro, in the fully kindled state, were altered by the earlier episodic corticosterone treatment. Thus, in kindled rats, the amplitude of the population spike in the CA1 area was significantly enhanced after prior exposure to high corticosterone levels. Prior episodic steroid treatment resulted furthermore in a significantly increased amplitude of voltage-gated Ca currents, in kindled rats. At that time, corticosterone levels of animals which had received a corticosterone-releasing pellet earlier were no longer elevated compared to the placebo controls; the corticosteroid-treated rats did also not differ from the controls with respect to the mRNA expression levels for the two corticosteroid receptor subtypes in the hippocampus. The data suggest that exposure of animals to a period of stressful experiences during a critical phase in epileptogenesis could impose lasting deleterious effects on the course of epilepsy, even when CORT levels have been normalized again.

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Section: Discussionmentioning

confidence: 99%

“…Several effects of elevated CORT levels on hippocampal cell function could underlie the accelerated epileptogenesis (Bradford 1995;Lopes da Silva et al . 1998).…”

Section: Discussionmentioning

confidence: 99%

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Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long‐term changes in hippocampal CA1 cells, in the fully kindled state

Karst

Kloet

Joëls

1999

Eur J of Neuroscience

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“…Corticosterone levels or chronic corticosteroid treatment have been reported to induce epileptogenesis [25,26]. The increase in corticosterone levels increased the degree of epileptogenesis by altering the functions of hippocampal cells [27]. Metyrapone was also used in this study to prevent cortisol increases related to meperidine use.…”

Section: Discussionmentioning

confidence: 95%

The Role of Adrenaline, Noradrenaline, and Cortisol in the Pathogenesis of the Analgesic Potency, Duration, and Neurotoxic Effect of Meperidine

Yilmaz,

Suleyman,

Mammadov

et al. 2023

Medicina

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Background and Objectives: The purpose of the study was to investigate the role of adrenaline (ADR), noradrenaline (NDR), and cortisol in the pathogenesis of the analgesic potency, duration, and epilepsy-like toxic effect of meperidine. Materials and Methods: The experimental animals were separated into 11 groups of six rats. In the meperidine (MPD) and metyrosine + meperidine (MMPD) groups, paw pain thresholds were measured before and after the treatment between the first and sixth hours (one hour apart). In addition, ADR and NDR analyses were performed before and after the treatment, between the first and fourth hours (one hour apart). For the epilepsy experiment, caffeine, caffeine + meperidine, and caffeine + meperidine + metyrapone groups were created, and the treatment was applied for 1 day or 7 days. Groups were created in which caffeine was used at both 150 mg/kg and 300 mg/kg. Epileptic seizures were observed in epilepsy groups, latent periods were determined, and serum cortisol levels were measured. Results: In the MPD group, pain thresholds increased only at the first and second hours compared to pre-treatment, while ADR increased at the third hour, leading to a decrease in pain thresholds. In the MMPD group, the increase in paw pain thresholds at 1 and 6 h was accompanied by a decrease in ADR and NDR. In the caffeine (150 mg/kg) + meperidine group, 1-day treatment did not cause epileptic seizures, while seizures were observed and cortisol levels increased in the group in which treatment continued for 7 days. When cortisol levels were compared between the group in which caffeine (300 mg/kg) + meperidine + metyrapone was used for 7 days and the animals receiving caffeine (300 mg/kg) + metyrapone for 7 days, it was found that cortisol levels decreased and the latent period decreased. Conclusions: The current study showed that if serum ADR and cortisol levels are kept at normal levels, a longer-lasting and stronger analgesic effect can be achieved with meperidine, and epileptic seizures can be prevented.

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Regional Specific Changes in Glutamate and GABAA Receptors, PKC Isozymes, and Ionic Channels in Kindling Epileptogenesis of the Hippocampus of the Rat

Cited by 2 publications

References 42 publications

Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long‐term changes in hippocampal CA1 cells, in the fully kindled state

Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long‐term changes in hippocampal CA1 cells, in the fully kindled state

The Role of Adrenaline, Noradrenaline, and Cortisol in the Pathogenesis of the Analgesic Potency, Duration, and Neurotoxic Effect of Meperidine

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