Regional regulation of focal adhesion kinase after concentric and eccentric loading is related to remodelling of human skeletal muscle

Franchi, Martino V.; Ruoss, Severin; Valdivieso, Paola; Mitchell, Kyle W.; Smith, Kenneth; Atherton, Philip J.; Narici, Marco V.; Flück, Martin

doi:10.1111/apha.13056

Cited by 70 publications

(74 citation statements)

References 64 publications

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“…Likewise, they reported that the content of activated costamere‐associated proteins increased more prominently at the distal site. This phenomenon, as suggested by the authors, may indicate a potential to preferentially increase the amount of myofibril Z‐bands in series (thus reflecting an FL increase) at the distal portion of the muscles (Franchi, Ruoss, et al, ). Although stretch training seems to elicit different responses at different sites along the muscle (Simpson et al, ), fascicle elongation also may be a consequence of decreases in stiffness of the connective tissue, particularly the perimysium, which is the largest extracellular contributor of tissue stiffness (Akagi & Takahashi, ; Purslow, ).…”

Section: Discussionmentioning

confidence: 70%

“…Despite the observed beneficial effects of stretch training on FL, the findings are not necessarily due to an increase in muscle fibre length. After eccentric training, Franchi et al (); Franchi, Ruoss, et al () observed higher growth in vastus lateralis cross‐sectional area at the distal site compared with the muscle belly. Likewise, they reported that the content of activated costamere‐associated proteins increased more prominently at the distal site.…”

Section: Discussionmentioning

confidence: 99%

“…In both the works of Akagi and Takahashi (2014) (Franchi, Raiteri, et al, 2018;Franchi, Ruoss, et al, 2018;Simpson et al, 2017), this may at least in part help to explain such differences. Additionally, in the study of Mizuno (2019), the stretch was carried out at an ankle angle whereby the calf muscles were fully stretched, while the stretch in Akagi and Takahashi (2014) was performed with a ~10% reduction in this angle and intensity.…”

Section: Discussion and Con Clus I On Smentioning

confidence: 99%

“…Moreover, Akagi and Takahashi () used a convex probe to measure the MT of the ankle flexors (from the adipose tissue–muscle interface of the posterior lower leg to the muscle–bone interface), whereas Mizuno () used a linear probe and measured only the lateral gastrocnemius. Considering that muscle portions may respond non‐uniformly to the muscle lengthening (Franchi, Raiteri, et al, ; Franchi, Ruoss, et al, ; Simpson et al, ), this may at least in part help to explain such differences. Additionally, in the study of Mizuno (), the stretch was carried out at an ankle angle whereby the calf muscles were fully stretched, while the stretch in Akagi and Takahashi () was performed with a ~10% reduction in this angle and intensity.…”

Section: Discussionmentioning

confidence: 99%

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Does stretch training induce muscle hypertrophy in humans? A review of the literature

Nunes

Schöenfeld

Nakamura

et al. 2020

Clin Physio Funct Imaging

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Stretch training is widely used in a variety of fitness‐related capacities such as increasing joint range of motion, preventing contractures and alleviating injuries. Moreover, some researches indicate that stretch training may induce muscle hypertrophy; however, studies on the topic have been primarily relegated to animal and in vitro models. The purpose of this brief review was to evaluate whether stretch training is a viable strategy to induce muscle hypertrophy in humans. An extensive literature search was performed using PubMed/MEDLINE, SciELO and Scopus databases, using terms related to stretching and muscle hypertrophy. Only human trials that evaluated changes in measures of muscle size or architecture following training protocols that it was performed stretching exercises were selected for inclusion. Of the 10 studies identified, 3 observed some significantly positive effects of stretch training on muscle structure. Intriguingly, in these studies, the stretching was carried out with an apparatus that aided in its performance, or with an external overload. In all studies, the subjects performed stretching at their own self‐determined range of motion, and no effect was observed. Of the 5 available studies that integrated stretching into a resistance training programme, 2 applied the stretching in the interset rest period and were the ones that showed enhanced muscle growth. In conclusion, passive, low‐intensity stretch does not appear to confer beneficial changes in muscle size and architecture; alternatively, albeit limited evidence suggests that when stretching is done with a certain degree of tensile strain (particularly when loaded, or added between active muscle contractions) may elicit muscle hypertrophy.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussion and Con Clus I On Smentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Does stretch training induce muscle hypertrophy in humans? A review of the literature

Nunes

Schöenfeld

Nakamura

et al. 2020

Clin Physio Funct Imaging

View full text Add to dashboard Cite

show abstract

“…Manuscripts from 2018 indicate how much attention very young manuscripts are receiving . Listed here are less than half of the original articles receiving double‐digit citations.…”

mentioning

confidence: 99%