Regional origin and decrease of pain in patients with depressive symptoms under treatment with venlafaxine

Begré, Stefan; Traber, Martin; Gerber, Martin; Känel, Roland von

doi:10.1007/s00127-009-0036-2

Cited by 5 publications

(3 citation statements)

References 27 publications

(42 reference statements)

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“…Age in years and sex were noted. Following the patients' regional origin, skin pigmentation was dummy coded as dark (Southern and Eastern Europe) or light (Middle Europe) [ 30 ]. We defined the six months with the least (November to April) and the most (May to October) statistical sunshine hours in Switzerland as winter and summer seasons, respectively [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Vitamin D Deficiency and Depressive Symptomatology in Psychiatric Patients Hospitalized with a Current Depressive Episode: A Factor Analytic Study

et al. 2015

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BackgroundLow vitamin D levels have been associated with depressive symptoms in population-based studies and non-clinical samples as well as with clinical depression. This study aimed to examine the association of vitamin D levels with the severity and dimensions of depressive symptoms in hospitalized patients with a current episode of depression taking into account confounding variables.MethodsWe investigated 380 patients (mean age 47±12 years, 70% women) who were consecutively hospitalized with a main diagnosis of an ICD-10 depressive episode. All patients self-rated depressive symptom severity with the Hospital Anxiety and Depression Scale (HADS-D), the Beck Depression Inventory-II (BDI-II), and the Brief Symptom Inventory. A principal component analysis was performed with all 34 items of these questionnaires and serum levels of 25-hydroxyvitamin D3 (25-OH D) were measured.ResultsVitamin D deficiency (<50 nmol/l), insufficiency (50–75 nmol/l), and sufficiency (>75 nmol/l) were present in 55.5%, 31.8% and 12.6%, respectively, of patients. Patients with vitamin D deficiency scored higher on the HADS-D scale and on an anhedonia symptom factor than those with insufficient (p-values ≤0.023) or sufficient (p-values ≤0.008) vitamin D. Vitamin D deficient patients also scored higher on the BDI-II scale than those with sufficient vitamin D (p = 0.007); BDI-II cognitive/affective symptoms, but not somatic/affective symptoms, were higher in patients with vitamin D deficiency (p = 0.005) and insufficiency (p = 0.041) relative to those with sufficient vitamin D. Effect sizes suggested clinically relevant findings.ConclusionsLow vitamin D levels are frequent in hospitalized patients with a current episode of depression. Especially 25-OH D levels <50 nmol/l were associated with cognitive/affective depressive symptoms, and anhedonia symptoms in particular.

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Section: Methodsmentioning

confidence: 99%

Vitamin D Deficiency and Depressive Symptomatology in Psychiatric Patients Hospitalized with a Current Depressive Episode: A Factor Analytic Study

et al. 2015

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“…Compared with men, women show greater mechanical pain sensitivity [30] and higher prevalence of fibromyalgia [31], and they also report more numerous and more intense bodily symptoms [32]. Vitamin D decreases with aging and is found to be lower in individuals with immigrant status [33], the latter also being associated with increased pain reports at several body sites [34].…”

Section: Demographic Factorsmentioning

confidence: 99%

Vitamin D and Central Hypersensitivity in Patients with Chronic Pain

Känel¹,

Müller-Hartmannsgruber

Kokinogenis

et al. 2014

Pain Med

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“…Depression negatively influences pain perception in the long-term [2, 34]. Other explanations may be disparity in sociocultural background, encountered challenges with yet less integration into society, and language barrier in the doctor-patient-relationship in Eastern compared to Middle European patients [6]. All these factors may prompt primary care physicians to refer their patients to a psychiatrist who is more educated for psychosocial and sociocultural issues.…”

Section: Discussionmentioning

confidence: 99%

Physician speciality and pain reduction in patients with depressive symptoms under treatment with venlafaxine

Begré

Traber²,

Gerber

et al. 2010

Eur. psychiatr.

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ObjectivesExcessive pain perception may lead to unnecessary diagnostic testing or invasive procedures resulting in iatrogenic complications and prolonged disability. Naturalistic studies on patients with chronic pain and depressive symptoms investigating the impact of medical speciality on treatment outcome in a primary care setting are lacking.MethodsIn this observational study, we examined whether the magnitude of pain reduction in 444 patients with depressive symptomatology under venlafaxine would relate differently to the medical speciality of the 122 treating physicians, namely psychiatrists (n = 110 patients), general practitioners (n = 236 patients), and internists (n = 98 patients).ResultsIndependent of age, gender, patient's region of origin, comorbidity, severity and duration of pain, and depressive symptoms at study entry, patients seemed to benefit significantly less in terms of pain reduction (p < 0.001) and of reduction in severity of depressive symptomatology by psychiatrists as compared to general practitioners (p < 0.019) and internists (p < 0.002).ConclusionsThe findings suggest that patients referred to psychiatrists are more difficult to treat than those referred to general practitioners and internists, and might not have been adequately prepared for psychiatric interventions. A supporting cooperation and networking between psychiatrists and primary care physicians may contribute to an integrated treatment concept and therefore, may lead to a better outcome in this challenging patient group.

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Regional origin and decrease of pain in patients with depressive symptoms under treatment with venlafaxine

Abstract: Objective Patient's language, tradition, conventions,

Cited by 5 publications

References 27 publications

Vitamin D Deficiency and Depressive Symptomatology in Psychiatric Patients Hospitalized with a Current Depressive Episode: A Factor Analytic Study

Vitamin D Deficiency and Depressive Symptomatology in Psychiatric Patients Hospitalized with a Current Depressive Episode: A Factor Analytic Study

Vitamin D and Central Hypersensitivity in Patients with Chronic Pain

Physician speciality and pain reduction in patients with depressive symptoms under treatment with venlafaxine

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