Regional odontodysplasia: An analysis of 161 cases from 1953 to 2017

Clinical, Radiographic and Histologic Evaluation of Regional Odontodysplasia: an Unusual Case Report with 6-Year Follow-Up

“…RO is normally unilateral and rarely crosses the midline, with the central, lateral and canine incisors being the most affected teeth, although the rest of the teeth in the arch may be involved. Bilateral maxillary involvement has been described in 4.3% and mandibular involvement in 9.3% of cases [10].…”

“…RO is usually observed in consecutive teeth, without healthy intermediate teeth. The first permanent molars are only affected if the adjacent primary molar shows RO [10].…”

Regional odontodysplasia – a rare developmental dental anomaly

“…Regional odontodysplasia is a rare developmental dental anomaly affecting ectodermal (enamel) and mesodermal tissues (dentine, cementum, pulp), mostly in one quadrant. The term "odontodysplasia" was first used by Zegarelli et al in 1963, and the prefix "regional" was added by Pindborg in 1970 [1][2][3]. Epidemiologic reports are rare -only 174 cases of regional odontodysplasia have been published in English up to January 2021.…”

“…Hypocalcification and hypoplasia of dental hard tissues involve both primary and permanent dentitions -in nearly half of the patients. This condition occurs more often in the maxilla (approximately twice), with a slight female predilection [1][2][3].…”

“…The potentially harmful local factor in the perinatal period is considered. In the literature, the possible causal fac-tors such as disorders of neural crest cell mi gration, local trauma or ischaemia, vascular defects, tera togenic medications, radiation, hyperpyrexia, activation of latent viruses, Rh incompatibility, and nutritional or metabolic deficiencies are mentioned [1,2,4].…”