Regional, national and international datasets: How they improve our understanding of the acute harms associated with prescription medicine misuse

Wood, David M.

doi:10.1111/bcp.14592

Cited by 10 publications

(11 citation statements)

References 41 publications

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“…In countries like the USA, Canada and Australia, misuse of psychoactive medicines has become a significant public health issue. 1 Opioid analgesics, sedatives, hypnotics and medicines used in opioid agonist treatment are reported to be the main type of medicines misused. 2 Regarding opioids, Canada, Australia and especially the USA, have been experiencing an opioid epidemic, 3 4 reflected in the significant morbidity and mortality in these countries currently associated with prescription opioid misuse, sometimes combined with benzodiazepines.…”

Section: Introductionmentioning

confidence: 99%

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Protocol for a scoping review on misuse of psychoactive medicines and its consequences

Araújo

Casal

Goulão³

et al. 2022

BMJ Open

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IntroductionMisuse of psychoactive medicines, especially prescription opioids, but also benzodiazepines, hypnotics and sedatives, has become a significant public health issue in some countries, especially in the USA, where it has been extensively documented, as well as in Canada and Australia. However, in the European Union (EU) published literature on the topic is scarce and heterogeneous regarding definitions, sources of data, tools and methods of analysis.The aim of this scoping review is to map the key concepts on psychoactive medicines’ misuse and examine the existing body of evidence on this topic in the EU. Data on the possible consequences of medicines’ misuse—adverse drug reactions, poisonings, hospitalisations and deaths—will also be analysed.Methods and analysisThe scoping review will follow the framework of Arksey and O’Malley, further developed by Levacet aland the Joanna Briggs Institute. The search strategy, developed by the authors, includes querying three electronic databases—PubMed, Web of Science and Scopus—using keywords and the Medical Subject Headings, for evidence published in English, French, Spanish or Portuguese between 2011 and 2020. Additionally, articles from PubMed alerts and other sources will also be considered. The results of the scoping review will describe the currently available evidence regarding misuse of medicines at EU level.Ethics and disseminationSince the scoping review methodology focuses on published data, this study does not require ethical approval. We will publish our findings in a peer-reviewed journal and plan to disseminate our work in conferences and scientific meetings.Registration detailsThis scoping review protocol is registered in the Open Science Framework (OSF; seehttps://osf.io/fzr9u) and has also been shared as a preprint in this free and open-source project management repository. It is available athttps://doi.org/10.31219/osf.io/y3s4q.

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Section: Introductionmentioning

confidence: 99%

“…In countries like the USA, Canada and Australia, misuse of psychoactive medicines has become a significant public health issue 1. Opioid analgesics, sedatives, hypnotics and medicines used in opioid agonist treatment are reported to be the main type of medicines misused 2.…”

Section: Introductionmentioning

confidence: 99%

Protocol for a scoping review on misuse of psychoactive medicines and its consequences

Araújo

Casal

Goulão³

et al. 2022

BMJ Open

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“…It also refers to the use of illicitly sourced prescription drugs, potentially counterfeit, contaminated or containing adulterants 3. Drugs identified with the greatest potential for misuse are prescription opioids, gabapentinoids, benzodiazepines, Z-drugs (eg, zopiclone, zolpidem) and psychostimulants (eg, methylphenidate) 1 4 5…”

Section: Introductionmentioning

confidence: 99%

Prescription drugs with potential for misuse: protocol for a multi-indicator analysis of supply, detection and the associated health burden in Ireland between 2010 and 2020

et al. 2023

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IntroductionThere is an increasing concern about the misuse of prescription drugs. Misuse refers to the intentional repurposing of prescribed drugs and/or the use of illicitly sourced prescription drugs, which may be counterfeit or contaminated. Drugs with the greatest potential for misuse are prescription opioids, gabapentinoids, benzodiazepines, Z-drugs and stimulants.ObjectiveThe aim of this study is to provide a comprehensive analysis of the supply, patterns of use and health burden associated with prescription drugs with potential for misuse (PDPM) in Ireland between 2010 and 2020. Three inter-related studies will be carried out. The first study will describe trends in supply of PDPM using law enforcement drug seizures data and national prescription records from national community and prison settings. The second study aims to estimate trends in the detection of PDPM across multiple early warning systems using national forensic toxicology data. The third study aims to quantify the health burden associated with PDPM nationally, using epidemiological indicators of drug-poisoning deaths, non-fatal intentional drug overdose presentations to hospitals and drug treatment demand.Methods and analysisA retrospective observational study design, with repeated cross-sectional analyses, using negative binomial regression models or, where appropriate, joinpoint regression.Ethics and disseminationThe study has received approval from the RCSI Ethics Committee (REC202202020). Results will be disseminated in peer-reviewed journals, scientific and drug policy meetings and with key stakeholders via research briefs.

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“…In countries like the United States of America, Canada and Australia, misuse of psychoactive medicines has become a significant public health issue 1 . Opioid analgesics, sedatives, hypnotics and medicines used in opioid agonist treatment are reported to be the main type of medicines misused 2 .…”

Section: Introductionmentioning

confidence: 99%

Protocol for a scoping review on misuse of psychoactive medicines and its consequences

Araújo¹,

Casal²,

Goulão³

et al. 2021

Preprint

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Background: Misuse of psychoactive medicines, especially prescription opioids, but also benzodiazepines, hypnotics and sedatives, has become a significant public health issue in some countries, especially in the USA, where it has been extensively documented. However, in the EU published literature is scarce, and almost absent in Portugal. Objectives: The aim of this scoping review is to map the key concepts on psychoactive medicines’ misuse and examine the existing body of evidence on this topic in Portugal and other EU countries. Data on the possible consequences of medicines’ misuse – adverse drug reactions, poisonings, hospitalisations and deaths – will also be collected.Methods: The scoping review will follow the framework of Arksey and O’Malley, further developed by Levac et al. and the Joanna Briggs Institute. The search strategy, developed by the authors, includes querying three electronic databases - PubMed, Web of Science and Scopus - using keywords and the Medical Subject Headings, for evidence published during a 10-year period up to 2020. Additionally, articles from PubMed alerts and other sources will also be considered. The current scoping review will include studies published in English, French, Spanish or Portuguese. Discussion: The results of this review will describe the current state of the art regarding misuse of medicines at EU level. Ethics and dissemination: Since the scoping review methodology focuses on published data, this study does not require ethical approval. We will publish our findings in a peer-reviewed journal and plan to disseminate our work in conferences and scientific meetings.

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Regional, national and international datasets: How they improve our understanding of the acute harms associated with prescription medicine misuse

Cited by 10 publications

References 41 publications

Protocol for a scoping review on misuse of psychoactive medicines and its consequences

Protocol for a scoping review on misuse of psychoactive medicines and its consequences

Prescription drugs with potential for misuse: protocol for a multi-indicator analysis of supply, detection and the associated health burden in Ireland between 2010 and 2020

Protocol for a scoping review on misuse of psychoactive medicines and its consequences

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