Regional myocardial perfusion and glucose metabolism in experimental left bundle branch block.

Ono, Shinji; Nohara, Ryuji; Kambara, Hirofumi; Okuda, Kazumi; Kawai, Chuichi

doi:10.1161/01.cir.85.3.1125

Cited by 143 publications

(77 citation statements)

References 26 publications

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“…1,2 Left bundlebranch block reduces myocardial perfusion in the septum because of impaired systolic thickening and augmented intramyocardial pressure in the septum. 24 The present findings also demonstrate an inhomogeneous perfusion pattern, with a reduced SLR of resting MBF. In line with data from Nowak et al 10 using SPECT, CRT was found to have a homogenizing effect on perfusion.…”

Section: Discussionsupporting

confidence: 71%

Effects of Cardiac Resynchronization Therapy on Myocardial Perfusion Reserve

et al. 2004

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Background-Cardiac resynchronization therapy (CRT) is a relatively new treatment strategy for patients with heart failure and mechanical asynchrony. Reported effects of CRT on regional myocardial blood flow (MBF) are conflicting, and effects on hyperemic MBF are scarce. The aim of the present study was to assess serial changes of MBF and MBF reserve in patients receiving a biventricular pacemaker. Methods and Results-Fourteen patients with heart failure (NYHA class III or IV; left ventricular ejection fraction Ͻ35%), QRS width Ͼ120 ms, and sinus rhythm were studied (mean age, 58Ϯ10 years; 8 men). MBF and hyperemic MBF were measured at baseline, 3 months after biventricular pacing (CRT on), and after cessation of pacing (CRT off) with PET and H 2

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Section: Discussionsupporting

confidence: 71%

Effects of Cardiac Resynchronization Therapy on Myocardial Perfusion Reserve

et al. 2004

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“…As a consequence, diastolic septal wall stress increases [39]. However, in the present study MVO 2 and MBF tend to be lowest in the septal wall.…”

Section: Regional Mvo 2 and Mbf In Dcm Patients With And Without Lbbbcontrasting

confidence: 61%

Global and regional myocardial oxygen consumption and blood flow in severe cardiomyopathy with left bundle branch block

Lindner

Vogt

Baller

et al. 2005

European Journal of Heart Failure

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Objective: In patients with dilated cardiomyopathy (DCM), left bundle branch block (LBBB) is a common finding. The characteristic feature is an asynchronous septal wall motion and most frequently a delay of the lateral and/or posterior wall segments. With the onset of cardiac resynchronization therapy, there is a focus on the specific pathophysiology of a LBBB. However, quantitative data on regional myocardial oxygen consumption (MVO 2 ) and blood flow (MBF) are missing. Methods: We studied 31 patients with severe DCM and LBBB (ejection fraction 22.1F7.1%) and 14 patients with mild to moderate DCM without LBBB (ejection fraction 46.7F7.9%). Global and regional MVO 2 as well as MBF were determined from a dynamic 11 C-acetate positron emission tomography (PET) study. Results: Global MVO 2 and MBF were lower in the DCM group with LBBB than in the control group ( Pb0.05). Regionally, the LBBB group revealed a higher ( Pb0.05) MVO 2 and MBF in the lateral wall than in the other walls. The control group did not show significant differences between the myocardial walls and demonstrated a smaller variability of the parameters. Conclusion: DCM patients with LBBB exhibit a more heterogeneous distribution of MVO 2 and MBF among the myocardial walls than DCM patients without LBBB. Due to the LBBB associated electromechanical alterations, the highest regional values of MVO 2 and MBF are found in the lateral wall.

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“…Myocardial scintigraphical studies of isolated LBBB patients demonstrated perfusion defects in the septum without coronary artery disease. LBBB per se may reduce myocardial perfusion and glucose uptake in the septum, because the interventricular asynchrony associated with LBBB causes excess systolic thickening and augmented intramyocardial pressure in the septum 13) . In addition, in patients with right ventricular pacing, a high incidence of myocardial perfusion defects in the septum associated with pacing induced artificial LBBB has been reported 10)14) .…”

Section: Discussionmentioning

confidence: 99%

Myocardial scintigraphy after pacemaker implantation for congenital complete atrioventricular block

et al. 2007

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Regional myocardial perfusion and glucose metabolism in experimental left bundle branch block.

Abstract: LBBB itself may reduce myocardial perfusion and glucose uptake in the septum because of impaired systolic thickening and augmented intramyocardial pressure in the septum; however, this is not necessarily related to septal ischemia.

Cited by 143 publications

References 26 publications

Effects of Cardiac Resynchronization Therapy on Myocardial Perfusion Reserve

Effects of Cardiac Resynchronization Therapy on Myocardial Perfusion Reserve

Global and regional myocardial oxygen consumption and blood flow in severe cardiomyopathy with left bundle branch block

Myocardial scintigraphy after pacemaker implantation for congenital complete atrioventricular block

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