Regional metabolite concentrations in the brain of healthy dogs measured by use of short echo time, single voxel proton magnetic resonance spectroscopy at 3.0 Tesla

Carrera, Inés; Richter, Henning; Meier, D.; Kircher, Patrick R.; Dennler, Matthias

doi:10.2460/ajvr.76.2.129

Cited by 13 publications

(33 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With regard to specific metabolite findings for the lobes interrogated, the differences detected between the thalamus and the parietal lobe for N‐ acetyl aspartase/choline were similar to the results of prior studies in people and dogs . A previous canine study reported differences in N‐ acetyl aspartase, choline, creatine, and myo ‐inositol for the following regions: basal ganglia, thalamus, parietal lobe, occipital lobe, and cerebellum . We found a difference between the parietal lobe and the thalamus, which is similar to a prior study in dogs .…”

Section: Discussionsupporting

confidence: 90%

“…Spectroscopy was successfully performed in six of eight dogs (Figure ). Spectra were deemed normal based on historically available comparisons in the available canine literature . Single‐voxel spectroscopy was performed with a mean acquisition time of 6.4 ± 0.26 min.…”

Section: Resultsmentioning

confidence: 99%

“…With single‐voxel spectroscopy, a single sample obtained from a one‐dimensional volume (typically ≥1 cm 3 ), is placed over a region of interest and acquired using point resolved spectroscopy or stimulated echo acquisition mode acquisition modes . Comparing the two techniques, single‐voxel spectroscopy can generally be performed with faster scan times with minimal lipid contamination, improved magnetic field homogeneity, and improved water suppression . For single‐voxel spectroscopy, placement of the voxel is crucial, as slight errors in voxel placement can lead to errors in interpretation of the spectral data due to the undesirable inclusion of regions of the brain, bone, gas filled sinuses, or adipose tissue .…”

Section: Discussionmentioning

confidence: 99%

“…Multi‐voxel spectroscopy requires longer acquisition times compared to single‐voxel spectroscopy and is more susceptible to contamination from adjacent voxels, notably air, bone, and adipose tissue . Multi‐voxel spectroscopy allows for total brain spectra and the acquisition of spectra from multiple locations and for signal refinement through various post‐processing techniques . The signal‐to‐noise ratio for multi‐voxel spectroscopy is generally greater than that of single‐voxel spectroscopy .…”

Section: Discussionmentioning

confidence: 99%

“…In people, magnetic resonance spectroscopy is clinically valuable for characterizing various brain lesions, including neoplastic, infectious, and inflammatory lesions, as well as traumatic brain injury . In contrast, information regarding magnetic resonance spectroscopy in the veterinary literature is limited . Two methods of performing magnetic resonance spectroscopy exist: single‐voxel spectroscopy and multi‐voxel spectroscopy .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Single‐voxel and multi‐voxel spectroscopy yield comparable results in the normal juvenile canine brain when using 3 Tesla magnetic resonance imaging

Lee

Beasley

Barrett

et al. 2018

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Conventional magnetic resonance imaging (MRI) characteristics of canine brain diseases are often nonspecific. Single- and multi-voxel spectroscopy techniques allow quantification of chemical biomarkers for tissues of interest and may help to improve diagnostic specificity. However, published information is currently lacking for the in vivo performance of these two techniques in dogs. The aim of this prospective, methods comparison study was to compare the performance of single- and multi-voxel spectroscopy in the brains of eight healthy, juvenile dogs using 3 Tesla MRI. Ipsilateral regions of single- and multi-voxel spectroscopy were performed in symmetric regions of interest of each brain in the parietal (n = 3), thalamic (n = 2), and piriform lobes (n = 3). In vivo single-voxel spectroscopy and multi-voxel spectroscopy metabolite ratios from the same size and multi-voxel spectroscopy ratios from different sized regions of interest were compared. No significant difference was seen between single-voxel spectroscopy and multi-voxel spectroscopy metabolite ratios for any lobe when regions of interest were similar in size and shape. Significant lobar single-voxel spectroscopy and multi-voxel spectroscopy differences were seen between the parietal lobe and thalamus (P = 0.047) for the choline to N-acetyl aspartase ratios when large multi-voxel spectroscopy regions of interest were compared to very small multi-voxel spectroscopy regions of interest within the same lobe; and for the N-acetyl aspartase to creatine ratios in all lobes when single-voxel spectroscopy was compared to combined (pooled) multi-voxel spectroscopy datasets. Findings from this preliminary study indicated that single- and multi-voxel spectroscopy techniques using 3T MRI yield comparable results for similar sized regions of interest in the normal canine brain. Findings also supported using the contralateral side as an internal control for dogs with brain lesions.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Single‐voxel and multi‐voxel spectroscopy yield comparable results in the normal juvenile canine brain when using 3 Tesla magnetic resonance imaging

Lee

Beasley

Barrett

et al. 2018

Vet Radiology Ultrasound

View full text Add to dashboard Cite

show abstract

Advances in High-Field MRI

Hespel

Cole

2018

Veterinary Clinics of North America: Small Animal Practice

View full text Add to dashboard Cite

Diagnostic techniques to detect the epileptogenic zone: Pathophysiological and presurgical analysis of epilepsy in dogs and cats

Hasegawa

2016

The Veterinary Journal

View full text Add to dashboard Cite

The use and availability of magnetic resonance imaging (MRI) and other neurosurgical devices is rapidly increasing in the field of veterinarian medicine. Coincident with these technological advances, there is an increased expectation to treat drug resistant epilepsy in dogs and cats by epilepsy surgery. However, the presurgical evaluation of epileptic animals, by using methodologies to detect the epileptogenic zone for example, have yet to become established in common practice. The epileptogenic zone, defined as the minimum amount of cortex to produce seizure freedom, consists of five conceptual cortical abnormal 'zones': symptomatogenic, irritative, seizure-onset, structurally abnormal (epileptogenic lesion) and functional deficit. These zones can now be detected by suitable modalities including ictal video monitoring, interictal non-invasive or invasive electroencephalography (EEG), ictal video-EEG, magnetoencephalography, structural and functional MRIs, or nuclear imaging. These diagnostic techniques are essential for selecting both appropriate patients and surgical techniques, and are also important in understanding the pathophysiology of epilepsy. This review describes the diagnostic techniques available for detecting each abnormal zone while considering the current veterinary status to realise future surgery for canine and feline epilepsy.

show abstract

Regional metabolite concentrations in the brain of healthy dogs measured by use of short echo time, single voxel proton magnetic resonance spectroscopy at 3.0 Tesla

Abstract: Metabolite concentrations differed among brain parenchymal regions in healthy dogs. This study may provide reference values for clinical and research studies involving (1)H MRS performed at 3.0 T.

Cited by 13 publications

References 51 publications

Single‐voxel and multi‐voxel spectroscopy yield comparable results in the normal juvenile canine brain when using 3 Tesla magnetic resonance imaging

Single‐voxel and multi‐voxel spectroscopy yield comparable results in the normal juvenile canine brain when using 3 Tesla magnetic resonance imaging

Advances in High-Field MRI

Diagnostic techniques to detect the epileptogenic zone: Pathophysiological and presurgical analysis of epilepsy in dogs and cats

Contact Info

Product

Resources

About