Regional Lung Function in Kyphoscoliosis

Idiopathic scoliosis. Gas exchange and the age dependence of arterial blood gases.

“…Second, in scoliosis the relative contribution of the diaphragm to the tidal volume is greater than normal (27), and this decreased contribution of the rib cage to inflation may contribute to an abnormal distribution of ventilation. Regional studies on the distribution of ventilation and blood flow have shown an abnormal distribution of ventilation and blood flow in scoliosis; however, there are no data on quantitative relationships between these abnormalities and indices of ventilation-blood flow maldistribution of blood gases (28)(29)(30)(31). Although our study has demonstrated statistically significant quantitative relationships between the indices of ventilationblood flow maldistribution and the lung volumes and the mechanical properties of the respiratory system, other techniques are required to demonstrate the mechanism of ventilation-blood flow maldistribution in scoliosis.…”

Observations on Regional Ventilation and Perfusion in Kyphoscoliosis

“…1-3) and certainly not to the de gree that is seen in patients with chronic ob structive airway disease with similar delays in the clearance of xenon-133 [Alderson et al, 1974|. Discussion There are a number of reports of pul monary function tests in patients with ky phoscoliosis [Chapman et al, 1939: Hanley et al, 1958Bergojsky et al, 1959;Naeye, Bruderman and Stein, 1961;Gucker, 1962) but only four that we can find on the regional distribution of ventilation and blood flow |Bjure and Nachemson, 1973;Dollery et al, 1965;Shannon et at., 1971;Bake et al, 1972). In each of these, the in vestigators used either multiple fixed detec tors or moving probes to determine the dis tribution of ventilation and blood flow.…”

“…In each of these, the in vestigators used either multiple fixed detec tors or moving probes to determine the dis tribution of ventilation and blood flow. Dollery et al [1965] studied 10 patients with severe scoliosis, 7 of whom had had an earlier spinal fusion or costectomy. Region al ventilation was measured as the distribu tion of a single breath of xenon-133 com pared to the distribution of lung volume af ter rebreathing the xenon-133 to equilibri um.…”

“…In none of the earlier studies was the whole of the washout procedure used as an indication of regional ventilation. Dollery et al [1965] and Shannon et al [1971] used the distribution of a single breath to the distribution of lung volume as their indication of ventilation, while Bjure et al [1973] and Bake et al [1972] made use of the first minute of the washout only. These latter workers recognized that in doing this, a region with a low ventilation to lung volume would be missed.…”

“…Previous studies of regional ventilation and blood flow in patients with kyphosco liosis used either multiple fixed or moving probes to detect the changes in radioactivity [Bjure and Nachemson, 1973;Dollery et al, 1965;Shannon et al, 1971;Bake et al, 19721. Furthermore, regional ventilation was measured using ventilation indices with little attention being paid to the latter parts of a washout procedure.…”