Regional Left Ventricular Wall Motion in Congestive Cardiomyopathy

Mathes, P.; Delius, W; Sebening, H; Wirtzfeld, A; Blömer, H

doi:10.1007/978-3-642-66772-5_16

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…Any baseline shift of the catheter-tipped transducer signal was corrected by simultaneous pressure recordings from the catheter-tipped transducer and the fluid-filled transducer. 4.2%, and the interobserver variability between the two independent observers was 5.4% with regard to digitized areas, indicating good reproducibility of the measurement.…”

Section: Cardiac Catheterizationmentioning

confidence: 84%

“…[4][5][6] Third, afterload reduction by vasodilators can improve left ventricular pump function in DCM29,30; the improvement is primarily due to the decrease in left ventricular wall stress. The present data showed that wall stress in DCM patients is significantly increased in the entire left ventricular wall and that percent area change correlated inversely to end-systolic regional wall stress in each area of the left ventricle ( Figure 5).…”

Section: Discussionmentioning

confidence: 99%

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Left ventricular regional wall stress in dilated cardiomyopathy.

et al. 1990

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Left ventriculography with simultaneous pressure micromanometry was performed in 11 normal control subjects and 17 patients with dilated cardiomyopathy (DCM). Left ventricular silhouettes in the right anterior oblique projection were divided into eight areas, and regional wall stress was computed by Janz's method in each area excluding the two most basal areas. Wall stress was higher in DCM patients than in control subjects (p<0.01). The percent area changes from end diastole to end systole in each area were lower in DCM patients than in control subjects (mean for six areas, 22+14% versus 54±9%o, respectively, p <0.01), but the coefficient of variation for the percent area changes in the six areas of the left ventricle in DCM patients was greater than that in control subjects (32±17% versus 15±4%, respectively, p<0.01), indicating regional differences in hypokinesis. There was a significant negative correlation between end-systolic regional wall stress and percent area change (r=-0.60 to -0.86, p<0.05) in each area. Thus, excessive regional afterload may play an important role in causing regional hypokinesis in DCM. (Circulation 1990;82:2075-2083 iffuse hypokinesis of the left ventricular wall D motion has been reported in patients with dilated cardiomyopathy (DCM).' However, recent studies on DCM with the use of left ventricular cineangiography2-5or radionuclide ventriculography6,7 suggest that left ventricular wall motion is not always diffusely hypokinetic and that regional differences in the degree of hypokinesis are frequently present. In clinical settings, patients with segmental wall motion abnormality may have better global left ventricular function and better prognosis than patients with diffuse wall motion abnormality.6 Thus, the importance of estimating left ventricular regional wall dynamics in patients with DCM has been emphasized.3-7

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Section: Cardiac Catheterizationmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Left ventricular regional wall stress in dilated cardiomyopathy.

et al. 1990

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“…Infectious processes as well as sarcoidosis involving the myocardium have been implicated as rare causes of left ventricular aneurysm [19], but to date there is no evidence that this occurs in the right ventricle. Regions of asynergy and aneurysm formation may occur in the left ventricle as a complication of primary cardiomyopathies [20], perhaps secondary to an area of severe localized myocarditis; again there is little evidence that this occurs in the right ventricle. Although our patient and the patient reported by Lyons et a1 [lo] had diffuse cardiomyopathies, both also had a history of chest wall trauma years before and the aneurysms may have been coincidental.…”

Section: Discussionmentioning

confidence: 99%

Right ventricular aneurysm: Clinical and laboratory features

Walker

Binkley

Neiger

et al. 1982

Cathet. Cardiovasc. Diagn.

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Asynergy and left ventricular performance in dilative cardiomyopathy

Zucchi¹,

Barsotti²,

Mariotti³

et al. 1987

Clinical Cardiology

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Summary: The purpose of this work was to evaluate the presence and importance of asynergy in dilative cardiomyopathy. A semiautomatized analysis of left ventriculograms was performed in 18 cases, the morphology of longitudinal and transverse axes time-length curves was evaluated, and mathematical indices of asynchrony and hypokinesis were defined. Ten normal subjects and 9 patients affected by aortic regurgitation were used as controls. In dilative cardiomyopathy, anomalous (polyphasic) time-length curves were present in 55 % of the cases, while they were absent in aortic regurgitation and in all normal subjects but one. In addition, the asynchrony index was slightly increased and the hypokinesis index significantly increased (28.8f7.2% vs. 17.8*7.1%, pc0.001). A negative correlation existed between the asynchrony index and the ejection fraction (r= -0.483, pc0.05) and both the ejection fraction and the maximum normalized velocity of contraction were reduced in the patients with the anomalous curves (29.7&6.9% vs. 46.0*11.5%, pc0.01; 1.66*0.52 s-' vs. 2.86f1.33 s-', pc0.02). It was concluded that asynergy, and especially asynchrony , is frequent in dilative cardiomyopathy and it is strongly associated with a major impairment of overall left ventricular function.

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Regional Left Ventricular Wall Motion in Congestive Cardiomyopathy

Cited by 8 publications

References 18 publications

Left ventricular regional wall stress in dilated cardiomyopathy.

Left ventricular regional wall stress in dilated cardiomyopathy.

Right ventricular aneurysm: Clinical and laboratory features

Asynergy and left ventricular performance in dilative cardiomyopathy

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