Regional investigation of lung function and microstructure parameters by localized <sup>129</sup>Xe chemical shift saturation recovery and dissolved‐phase imaging: A reproducibility study

Kern, A.; Gutberlet, Marcel; Qing, Kun; Voskrebenzev, Andreas; Klimeš, Filip; Kaireit, Till F.; Czerner, Christoph; Biller, Heike; Wacker, Frank; Ruppert, K.; Hohlfeld, Jens M.; Vogel‐Claussen, Jens

doi:10.1002/mrm.27407

Cited by 22 publications

(26 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results indicate high repeatability of the whole‐lung mean values, especially for RBC:Barrier. The values we report are generally in agreement with previous estimates measured with whole‐lung spectroscopy and alternative regional spectroscopic imaging methods . It is possible to begin to estimate CR for dissolved‐phase ratios necessary to evaluate progression.…”

Section: Discussionsupporting

confidence: 87%

“…The values we report are generally in agreement with previous estimates measured with whole-lung spectroscopy 12 and alternative regional spectroscopic imaging methods. 16 It is possible to begin to estimate CR for dissolved-phase ratios necessary to evaluate progression. Based on our Bland-Altman analysis, these CR's are 0.37, 0.14, and 0.09 for whole-lung mean values of the Barrier:Gas, RBC:Gas, and RBC:Barrier ratios, respectively.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Repeatability of regional pulmonary functional metrics of Hyperpolarized ¹²⁹Xe dissolved‐phase MRI

Hahn

Kammerman

Evans

et al. 2019

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background MRI of hyperpolarized 129Xenon (HP 129Xe) is increasingly utilized for investigating pulmonary function. The solubility of HP 129Xe in lung tissue, blood plasma (Barrier), and red blood cells (RBC), with unique chemical shifts, enables spectroscopic imaging of potential imaging biomarkers of gas exchange and microstructural pulmonary physiology. Purpose To quantify global average and regional repeatability of Barrier:gas, RBC:gas, and RBC:Barrier ratios derived from dissolved‐phase 129Xe imaging and their dependence on intervisit changes in lung inflation volume. Study Type Prospective. Population Fourteen healthy volunteers. One subject was unable to complete the study resulting in 13 subjects for analysis (eight female, five male, ages 24–69, 53.8 ± 13.9). Field Strength 1.5T. Assessment Subjects were imaged using a 3D radial 1‐point Dixon method to separate Barrier and RBC component signals, at two different timepoints, with ~1 month between visits. RBC:Gas, Barrier:Gas, and RBC:Barrier measures were compared across time and with pulmonary function tests (PFTs). Statistical Tests Repeatablilty was quantified using Bland–Altman plots, coefficient of repeatability, coefficient of variation (CV), and intraclass correlation coefficients (ICCs). Dependence of imaging measures on PFTs and lung volume was evaluated using Spearman and Pearson correlation coefficients, respectively. Statistical significance was determined by F‐test for intraclass correlations, and t‐test for Spearman correlations and regression. Results Mean RBC:Gas, Barrier:Gas, and RBC:Barrier had CVs of 19.2%, 20.0%, and 11.5%, respectively, and had significant ICCs, equal to 0.78, 0.79, and 0.92, respectively. Intervisit differences in RBC:Barrier were significantly correlated with intervisit differences in DLCO (r = 0.93, P = 0.007). Significant correlations with intervisit lung volume differences and intervisit differences in mean RBC:Gas (r = –0.73, P = 0.005) and Barrier:Gas (r = –0.69, P = 0.009) were found. Data Conclusion Three commonly used 129Xe MRI‐based measures of gas‐exchange show good repeatability, particularly the Barrier:RBC ratio, which did not depend on lung inflation volume and was strongly associated with intervisit changes in DLCO. Level of Evidence: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:1182–1190.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Repeatability of regional pulmonary functional metrics of Hyperpolarized ¹²⁹Xe dissolved‐phase MRI

Hahn

Kammerman

Evans

et al. 2019

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…The reproducibility of chemical shift saturation recovery measurements in COPD patients has been assessed previously . The microstructural parameters TP wall thickness and TP S/V have similar median coefficients of variation in CSSR mapping (7.4%/7.5%) compared to the results for CSSR spectroscopy obtained in Ref.…”

Section: Discussionmentioning

confidence: 76%

“…The CSSR spectroscopy sequence featured 2.4 ms‐long rectangular saturation pulses centered on the TP or RBC resonance, respectively. After 1 of 21 different delay times, a 1.2 ms‐long Gaussian pulse centered on the 129 Xe dissolved‐phase frequency was irradiated, and the signal acquired at a bandwidth of ± 16.67 kHz and a readout duration of 30.72 ms.…”

Section: Methodsmentioning

confidence: 99%

“…11,12 The latter technique is known as chemical shift saturation recovery (CSSR) spectroscopy [13][14][15] and has been shown to be sensitive for structural changes of the lung on a subclinical level. 16,17 However, because standard implementations of CSSR do not feature any spatial encoding, regional information is usually lacking and there have been efforts to resolve this issue. 16,[18][19][20][21][22][23][24][25] Certain lung microstructural parameters can also be obtained using gas diffusion MRI and models of acinar microstructure.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mapping of regional lung microstructural parameters using hyperpolarized ¹²⁹Xe dissolved‐phase MRI in healthy volunteers and patients with chronic obstructive pulmonary disease

Kern

Gutberlet

Voskrebenzev

et al. 2018

Magnetic Resonance in Med

Self Cite

View full text Add to dashboard Cite

Purpose To develop a novel technique for voxel‐based mapping of lung microstructural parameters using hyperpolarized 129Xe dissolved‐phase MR imaging during saturation recovery. Methods A pulse sequence using a highly undersampled stack‐of‐stars trajectory was developed, and low‐rank plus sparse matrix decomposition was employed for reconstruction of regional 129Xe uptake dynamics into lung tissue. In 4 healthy volunteers and 9 patients with chronic obstructive pulmonary disease, the technique was tested and compared to chemical shift saturation recovery spectroscopy in patients. Reproducibility of 129Xe gas uptake imaging was assessed by computing coefficients of variation, and results were compared with other modalities. Results Numerical simulations and results from in vivo measurements in patients with chronic obstructive pulmonary disease showed that septal wall thickness and surface‐to‐volume ratio can be measured with an accuracy close to spectroscopic measurements. The average of the microstructural parameters of the total lung volume showed good reproducibility (coefficient of variation wall thickness: 7.4% coefficient of variation surface‐to‐volume ratio: 7.5%) and correlated strongly with the findings of global chemical shift saturation recovery spectroscopy. Gravitational gradients of microstructural parameters and increased heterogeneity in chronic obstructive pulmonary disease patients were observed. Conclusion A novel technique for mapping of regional lung microstructural parameters was introduced, and its feasibility was shown in healthy volunteers and chronic obstructive pulmonary disease patients.

show abstract

Ventilation/Perfusion Relationships and Gas Exchange: Measurement Approaches

Hopkins

2020

Comprehensive Physiology

View full text Add to dashboard Cite

Regional investigation of lung function and microstructure parameters by localized ¹²⁹Xe chemical shift saturation recovery and dissolved‐phase imaging: A reproducibility study

Abstract: Localized Xe CSSR provides reproducible estimates of alveolar wall thickness and is able to detect regional differences of lung microstructure.

Cited by 22 publications

References 25 publications

Repeatability of regional pulmonary functional metrics of Hyperpolarized ¹²⁹Xe dissolved‐phase MRI

Repeatability of regional pulmonary functional metrics of Hyperpolarized ¹²⁹Xe dissolved‐phase MRI

Mapping of regional lung microstructural parameters using hyperpolarized ¹²⁹Xe dissolved‐phase MRI in healthy volunteers and patients with chronic obstructive pulmonary disease

Ventilation/Perfusion Relationships and Gas Exchange: Measurement Approaches

Contact Info

Product

Resources

About

Regional investigation of lung function and microstructure parameters by localized 129Xe chemical shift saturation recovery and dissolved‐phase imaging: A reproducibility study

Abstract: Localized Xe CSSR provides reproducible estimates of alveolar wall thickness and is able to detect regional differences of lung microstructure.

Cited by 22 publications

References 25 publications

Repeatability of regional pulmonary functional metrics of Hyperpolarized 129Xe dissolved‐phase MRI

Repeatability of regional pulmonary functional metrics of Hyperpolarized 129Xe dissolved‐phase MRI

Mapping of regional lung microstructural parameters using hyperpolarized 129Xe dissolved‐phase MRI in healthy volunteers and patients with chronic obstructive pulmonary disease

Ventilation/Perfusion Relationships and Gas Exchange: Measurement Approaches

Contact Info

Product

Resources

About

Regional investigation of lung function and microstructure parameters by localized ¹²⁹Xe chemical shift saturation recovery and dissolved‐phase imaging: A reproducibility study

Repeatability of regional pulmonary functional metrics of Hyperpolarized ¹²⁹Xe dissolved‐phase MRI

Repeatability of regional pulmonary functional metrics of Hyperpolarized ¹²⁹Xe dissolved‐phase MRI

Mapping of regional lung microstructural parameters using hyperpolarized ¹²⁹Xe dissolved‐phase MRI in healthy volunteers and patients with chronic obstructive pulmonary disease