Regional increases in rat nasal epithelial cell proliferation following acute and subchronic inhalation of formaldehyde*1

Monticello, Thomas M.; Miller, Frederick J.; Morgan, K.T.

doi:10.1016/0041-008x(91)90246-b

Cited by 124 publications

(69 citation statements)

References 26 publications

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“…The nasal epithelium has considerable plasticity in its differentiation in reaction to stimuli. 7,10 Neuroendocrine cells are widely scattered in the epithelium of the respiratory tract. 6,12,18 The histologic variety of malignant epithelial tumors in the nasal cavity and paranasal sinuses may reflect these anatomic complexities of the nasal mucosa.…”

Section: Discussionmentioning

confidence: 99%

Nasal and Paranasal Adenocarcinomas with Neuroendocrine Differentiation in Dogs

et al. 2008

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Abstract. Tumors of the nasal cavity or paranasal sinuses of 18 dogs were examined histopathologically, immunohistochemically, and histochemically. The tumors were classified histologically as 13 adenocarcinomas, 3 transitional carcinomas, 1 squamous cell carcinoma, and 1 adenosquamous carcinoma. Tumor cells were strongly immunoreactive for broad-spectrum cytokeratins in all cases, for cytokeratin 8/18 in 16 cases, and for cytokeratin 19 in 17 cases. None of the 18 carcinomas had cytologic or histologic features indicative of neuroendocrine differentiation, yet tumor cells in 5 of the 13 adenocarcinomas were argyrophilic and immunohistochemically positive for synaptophysin and chromogranin A. Results of this study indicate that neuroendocrine markers may be detected immunohistochemically and histochemically in canine nasal or paranasal adenocarcinomas despite the lack of typical histologic features of neuroendocrine differentiation.

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Section: Discussionmentioning

confidence: 99%

Nasal and Paranasal Adenocarcinomas with Neuroendocrine Differentiation in Dogs

et al. 2008

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“…The cellular process of detoxification of xenobiotics such as dichlorvos and formalin involves the formation of free-radical species that, as well as inducing lipid peroxidation, can have an influence on the signal transduction mechanisms that control cell growth, through the production of the PUFA derivatives, prostaglandins (Burdon and Rice-Evans 1989). This could account for the carcinogenic potential of some compounds and although this is not well established for dichlorvos (Cunningham et al 1994), there is substantial evidence for formaldehyde-induced cell proliferation in mammalian respiratory tissues (Monticello et al 1991).…”

Section: Discussionmentioning

confidence: 99%

Untitled

Ghioni¹,

Tocher²,

Sargent³

1998

Fish Physiology and Biochemistry

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The effects of sub-lethal doses of dichlorvos and formalin, antimicrobial/parasitic agents used in aquaculture, on lipid composition and metabolism of rainbow trout skin cells in primary culture were investigated. Both dichlorvos and, especially, formalin appeared to significantly inhibit Δ9 and Δ6 desaturase.Changes in the distribution of radioactivity between individual phospholipid classes was also influenced by formalin and dichlorvos, and this may be related to changes in desaturase activity. This study has shown that topically active agents used in aquaculture, formalin and dichlorvos, had a range of effects on the rainbow trout skin cell cultures that may affect cell proliferation and lipid and fatty acid metabolism. Both agents significantly inhibited desaturation of fatty acids, particularly of 18:2n-6 to 20:4n-6 and, as 20:4n-6 is a major eicosanoid precursor in fish and considering the importance of eicosanoids in the biochemistry of skin ,it is suggested that these agents may have direct effects on fish skin that may have important consequences for fish health in general.3

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“…Formaldehyde-induced elevations in nasal cell proliferation may, therefore, have special relevance in the carcinogenic process. Recent studies have shown that formaldehyde-induced nasal lesions and increases in cell proliferation after acute (1, 4, 9 days or 6 weeks) or subchronic (3-month) exposure are concentration dependent and occur in specific regions of the anterior nasal passages, primarily the walls of the lateral meatus, septum adjacent to the middle meatus, and medial aspect of the maxilloturbinate (5,20). The increases in cell proliferation were associated with nasal lesions, including degeneration, necrosis, hyperplasia, and squamous metaplasia.…”

Section: Formaldehyde-induced Cell Proliferationmentioning

confidence: 99%

Cell proliferation and nasal carcinogenesis.

Monticello

Gross

Morgan

1993

Environ Health Perspect

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The nasal passages of rodents provide valuable opportunities for research on relationships between cell proliferation and cancer. The nose, which has multiple functions, possesses a diverse range of tissue types, each with its own morphologic, physiologic, and metabolic characteristics and site-specific cell turnover rates. Moreover, for inhaled materials deposited in the nose, complex regional uptake or deposition patterns can result in site-specific responses, including cancer. Presented here are important criteria necessary for undertaking cell proliferation studies in the nasal passages. The current literature concerning nasal toxicity and the toxicant-induced proliferative response are also reviewed. Rodent nasal epithelium provides a fruitful area for research on the role of cell proliferation in carcinogenesis.

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Regional increases in rat nasal epithelial cell proliferation following acute and subchronic inhalation of formaldehyde*1

Cited by 124 publications

References 26 publications

Nasal and Paranasal Adenocarcinomas with Neuroendocrine Differentiation in Dogs

Nasal and Paranasal Adenocarcinomas with Neuroendocrine Differentiation in Dogs

Untitled

Cell proliferation and nasal carcinogenesis.

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