Regional Hypothermia Inhibits Spinal Cord Somatosensory-Evoked Potentials without Neural Damage in Uninjured Rats

Li, Ning; Tian, Lei; Wu, Wei; Lu, Huchen; Zhou, Yuan; Xu, Xiaoyu; Zhang, Xiangsheng; Cheng, Huilin; Zhang, Lihua

doi:10.1089/neu.2012.2516

Cited by 9 publications

(4 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same research group also demonstrated that hESCs-OPCs transplantation was associated with better sparing of grey and white matter, attenuated cavitation, and altered gene expression (e.g., interleukin-10 (IL-10), hepatocyte growth factor (HGF), and Fas) in cervical spinal cord contusion [ 41 ]. In terms of somatosensory evoked potentials (SSEPs) as a surrogate of ascending pathway integrity [ 186 ], animals were found to have significant improvement in both amplitudes and latencies following transplantation [ 42 ].…”

Section: Roles Of Oligodendrocyte Precursor Cells After Spinal Cormentioning

confidence: 99%

Oligodendrocyte Precursor Cells in Spinal Cord Injury: A Review and Update

Leung

2015

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Spinal cord injury (SCI) is a devastating condition to individuals, families, and society. Oligodendrocyte loss and demyelination contribute as major pathological processes of secondary damages after injury. Oligodendrocyte precursor cells (OPCs), a subpopulation that accounts for 5 to 8% of cells within the central nervous system, are potential sources of oligodendrocyte replacement after SCI. OPCs react rapidly to injuries, proliferate at a high rate, and can differentiate into myelinating oligodendrocytes. However, posttraumatic endogenous remyelination is rarely complete, and a better understanding of OPCs' characteristics and their manipulations is critical to the development of novel therapies. In this review, we summarize known characteristics of OPCs and relevant regulative factors in both health and demyelinating disorders including SCI. More importantly, we highlight current evidence on post-SCI OPCs transplantation as a potential treatment option as well as the impediments against regeneration. Our aim is to shed lights on important knowledge gaps and to provoke thoughts for further researches and the development of therapeutic strategies.

show abstract

Section: Roles Of Oligodendrocyte Precursor Cells After Spinal Cormentioning

confidence: 99%

Oligodendrocyte Precursor Cells in Spinal Cord Injury: A Review and Update

Leung

2015

BioMed Research International

Self Cite

View full text Add to dashboard Cite

show abstract

“…SSEP do not preclude intraoperative use of muscle relaxants, which makes anesthesia management easier. Limitations of the method include sensitivity to anesthesia, hemodynamic changes and hypothermia [10,49,50].…”

Section: Monitoring During Spinal Surgerymentioning

confidence: 99%

Neurophysiological Monitoring during Surgery on the Central Nervous System: The Role of Evoked Responses

Soghomonyan

2015

IJAR

View full text Add to dashboard Cite

Neurosurgical, orthopedic and vascular interventions may be associated with an inherent risk of ischemia and structural damage to the central nervous system. Along with other modalities used to monitor the intraoperative nervous function, registration of evoked responses is intended to provide real-time feedback about the functional integrity of the central nervous system and help to prevent avoidable trauma during surgery. In this review, the principal indications and limitations of monitoring various evoked responses during surgery on the brain and spinal cord are discussed. Current approaches, recent advances and problems associated with intraoperative rhomboid fossa mapping, cranial nerve stimulation and electrooculographic monitoring are presented as well. The authors discuss the effects of general anesthesia on evoked responses and possible ways to avoid signal variability during registration. It is emphasized that only with close cooperation between neurosurgeons, anesthesiologists and neurophysiologists it will be possible to maximize the benefits of intraoperative monitoring of evoked responses and avoid misinterpretation of the results.

show abstract

“…Noninvasive methods, which are the most desirable, are easy to execute. However, they present difficulties in localizing and maintaining the desired temperature for the necessary period of time (Yoshitake et al, 2007;Levi et al, 2010;Morizane et al, 2012;Li et al, 2013). In this study, we investigated the feasibility of localizing and maintaining prolonged moderate local hypothermia through a semi-invasive method that could easily be translated to a noninvasive method applicable in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

Prolonged Local Hypothermia Has No Long-Term Adverse Effect on the Spinal Cord

Vipin

Kortelainen

Al‐Nashash

et al. 2015

Therapeutic Hypothermia and Temperature Management

View full text Add to dashboard Cite

Hypothermia is known to be neuroprotective and is one of the most effective and promising first-line treatments for central nervous system (CNS) trauma. At present, induction of local hypothermia, as opposed to general hypothermia, is more desired because of its ease of application and safety; fewer side effects and an absence of severe complications have been noted. Local hypothermia involves temperature reduction of a small and specific segment of the spinal cord. Our group has previously shown the neuroprotective effect of short-term, acute moderate general hypothermia through improvements in electrophysiological and motor behavioral assessments, as well as histological examination following contusive spinal cord injury (SCI) in rats. We have also shown the benefit of using short-term local hypothermia versus short-term general hypothermia post-acute SCI. The overall neuroprotective benefit of hypothermia can be categorized into three main components: (1) induction modality, general versus local, (2) invasive, semi-invasive or noninvasive, and (3) duration of hypothermia induction. In this study, a series of experiments were designed to investigate the feasibility, long-term safety, as well as eventual complications and side effects of prolonged, semi-invasive, moderate local hypothermia (30°C±0.5°C for 5 and 8 hours) in rats with uninjured spinal cord while maintaining their core temperature at 37°C±0.5°C. The weekly somatosensory evoked potential and motor behavioral (Basso, Beattie and Bresnahan) assessments of rats that underwent 5 and 8 hours of semi-invasive local hypothermia, which revealed no statistically significant changes in electrical conductivity and behavioral outcomes. In addition, 4 weeks after local hypothermia induction, histological examination showed no anatomical damages or morphological changes in their spinal cord structure and parenchyma. We concluded that this method of prolonged local hypothermia is feasible, safe, and has the potential for clinical translation.

show abstract

Regional Hypothermia Inhibits Spinal Cord Somatosensory-Evoked Potentials without Neural Damage in Uninjured Rats

Cited by 9 publications

References 39 publications

Oligodendrocyte Precursor Cells in Spinal Cord Injury: A Review and Update

Oligodendrocyte Precursor Cells in Spinal Cord Injury: A Review and Update

Neurophysiological Monitoring during Surgery on the Central Nervous System: The Role of Evoked Responses

Prolonged Local Hypothermia Has No Long-Term Adverse Effect on the Spinal Cord

Contact Info

Product

Resources

About