Regional Homogeneity in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study

Wu, Yu-Qian; Zhang, Lijuan; Liu, Li-Qi; Pan, Yi‐Cong; Su, Ting; Liao, Xu‐Lin; Shu, Hui‐Ye; Kang, Min; Ping, Ying; Xu, San-Hua; Shao, Yi

doi:10.3389/fnagi.2022.877281

Cited by 5 publications

(1 citation statement)

References 36 publications

(34 reference statements)

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“…In clinical research, Wu YQ, et al . found that the bilateral inferior temporal gyrus signal was significantly lower in mild cognitive impairment (MCI) patients than that in healthy subjects [ 63 ], indicating that the decreased activity of the bilateral inferior temporal gyrus may be involved in cognitive impairment. The relationship between BOLD changes and AD risk genes (especially APOEε4) has been extensively studied.…”

Section: The Energy Dysmetabolism In Alzheimer’s Disease Brainmentioning

confidence: 99%

Energy Crisis Links to Autophagy and Ferroptosis in Alzheimer’s Disease: Current Evidence and Future Avenues

Fan

Wang

2023

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Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases worldwide. The occult nature of the onset and the uncertainty of the etiology largely impede the development of therapeutic strategies for AD. Previous studies revealed that the disorder of energy metabolism in the brains of AD patients appears far earlier than the typical pathological features of AD, suggesting a tight association between energy crisis and the onset of AD. Energy crisis in the brain is known to be induced by the reductions in glucose uptake and utilization, which may be ascribed to the diminished expressions of cerebral glucose transporters (GLUTs), insulin resistance, mitochondrial dysfunctions, and lactate dysmetabolism. Notably, the energy sensors such as peroxisome proliferators-activated receptor (PPAR), transcription factor EB (TFEB), AMP-activated protein kinase (AMPK) were shown to be the critical regulators of autophagy, and autophagy plays important roles in regulating beta-amyloid (Aβ) metabolism, tau phosphorylation, neuroinflammation, iron dynamics, as well as ferroptosis. In this study, we summarized the current knowledge on the molecular mechanisms involved in the energy dysmetabolism of AD, and discussed the interplays existing between energy crisis, autophagy and ferroptosis. In addition, we highlighted the potential network that autophagy may serve as a bridge between energy crisis and ferroptosis in the progression of AD. A deeper understanding of the relationship between energy dysmetabolism and AD may provide new strategies for treating AD, meanwhile, the energy crisis in the progression of AD should gain more attention.

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Section: The Energy Dysmetabolism In Alzheimer’s Disease Brainmentioning

confidence: 99%

Energy Crisis Links to Autophagy and Ferroptosis in Alzheimer’s Disease: Current Evidence and Future Avenues

Fan

Wang

2023

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Altered regional homogeneity following moxibustion in mild cognitive impairment

Zhang,

Liang,

Lai

et al. 2023

Brain Imaging and Behavior

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BackgroundMoxibustion has de nite clinical effect in improving the cognitive condition of mild cognitive impairment (MCI) patients, yet its potential neural mechanism remains elusive. This study aimed to investigate the changes of spontaneous brain activity and cognitive function in MCI patients with moxibustion treatment. MethodsWe enrolled a cohort of 30 MCI patients and 30 matched healthy controls (HCs) in this study. MCI subjects were assigned to receive moxibustion treatment for two months. Based on resting state functional magnetic resonance imaging technique, we used regional homogeneity (ReHo) to evaluate changes in brain activity and Mini-Mental State Examination and Montreal Cognitive Assessment to assess changes in the participants' cognitive performance. ResultsThere existed aberrant ReHo values in different brain areas mainly involved in the default mode network (DMN) in MCI subjects compared with HCs. After moxibustion treatment, MCI subjects showed an inverse change in ReHo values from baseline in the hippocampus/parahippocampus and insula, as well as an increase ReHo value in the middle frontal gyrus. Furthermore, changes in ReHo values of the left hippocampus/parahippocampus and middle frontal gyrus correlated with cognitive improvement in MCI group. ConclusionAbnormal neural activity occurred in MCI subjects mainly within the DMN. Moxibustion therapy may improve the cognitive function of MCI subjects through regulating their brain activity, particularly reversing the neural activity of DMN and salience network at reset, and may hold great potential for the early intervention and treatment of Alzheimer's disease.

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Convergent and distinct neural structural and functional patterns of mild cognitive impairment: a multimodal meta-analysis

et al. 2023

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Mild cognitive impairment (MCI) is regarded as a transitional stage between normal aging and Alzheimer’s disease. Numerous voxel-based morphometry (VBM) and resting-state fMRI (rs-fMRI) studies have provided strong evidence of abnormalities in the structure and intrinsic function of brain regions in MCI. Studies have recently begun to explore their association but have not employed systematic information in this pursuit. Herein, a multimodal meta-analysis was performed, which included 43 VBM datasets (1,247 patients and 1,352 controls) of gray matter volume (GMV) and 42 rs-fMRI datasets (1,468 patients and 1,605 controls) that combined 3 metrics: amplitude of low-frequency fluctuation, the fractional amplitude of low-frequency fluctuation, and regional homogeneity. Compared to controls, patients with MCI displayed convergent reduced regional GMV and altered intrinsic activity, mainly in the default mode network and salience network. Decreased GMV alone in ventral medial prefrontal cortex and altered intrinsic function alone in bilateral dorsal anterior cingulate/paracingulate gyri, right lingual gyrus, and cerebellum were identified, respectively. This meta-analysis investigated complex patterns of convergent and distinct brain alterations impacting different neural networks in MCI patients, which contributes to a further understanding of the pathophysiology of MCI.

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Regional Homogeneity in Patients With Mild Cognitive Impairment: A Resting-State Functional Magnetic Resonance Imaging Study

Cited by 5 publications

References 36 publications

Energy Crisis Links to Autophagy and Ferroptosis in Alzheimer’s Disease: Current Evidence and Future Avenues

Energy Crisis Links to Autophagy and Ferroptosis in Alzheimer’s Disease: Current Evidence and Future Avenues

Altered regional homogeneity following moxibustion in mild cognitive impairment

Convergent and distinct neural structural and functional patterns of mild cognitive impairment: a multimodal meta-analysis

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