Regional heterogeneity in the distribution of neurotransmitter markers in the rat hippocampus

Hörtnagl, Heide; Berger, Michael L.; Sperk, Günther; Pifl, Christian

doi:10.1016/0306-4522(91)90224-c

Cited by 115 publications

(73 citation statements)

References 59 publications

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“…Levels of neuropeptide Y and concentrations of glycine and aspartate were equally distributed across the septotemporal axis. Only concentrations of the amino acid taurine were higher in the septal hippocampus (Hortnagl et al 1991). The investigators suggest that these results may indicate a denser innervation of the temporal hippocampus raising the possibility that systemic neurotransmitter administration may preferentially alter signaling in the temporal hippocampus.…”

Section: Molecular Markersmentioning

confidence: 70%

“…Gage and colleagues showed higher concentrations of norepinephrine (NE) and serotonin (5-HT) in the temporal half of the rat hippocampus (Gage et al 1978), along with a corresponding increase in the distribution of NE and 5-HT nerve terminals (Gage and Thompson 1980). This analysis has also been extended to multiple classes of neurotransmitters (Hortnagl et al 1991). Temporally enriched markers included concentrations of GABA, glutamate, dopamine, noradrenaline and its metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), serotonin and its metabolite 5-hydroxyindoleacetic acid (HIAA), levels of somatostatin, and enzymatic activity of choline acetyltransferase, acetylcholinesterase, and glutamate decarboxylase.…”

Section: Molecular Markersmentioning

confidence: 97%

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Functional Differentiation of Adult-Born Neurons along the Septotemporal Axis of the Dentate Gyrus: Figure 1.

Sahay

Duman

et al. 2015

Cold Spring Harb Perspect Biol

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Over the past several decades, the proliferation and integration of adult-born neurons into existing hippocampal circuitry has been implicated in a wide range of behaviors, including novelty recognition, pattern separation, spatial learning, anxiety behaviors, and antidepressant response. In this review, we suggest that the diversity in behavioral requirements for new neurons may be partly caused by separate functional roles of individual neurogenic niches. Growing evidence shows that the hippocampal formation can be compartmentalized not only along the classic trisynaptic circuit, but also along a longitudinal septotemporal axis. We suggest that subpopulations of hippocampal adult-born neurons may be specialized for distinct mnemonic-or mood-related behavioral tasks. We will examine the literature supporting a functional and anatomical dissociation of the hippocampus along the longitudinal axis and discuss techniques to functionally dissect the roles of adult-born hippocampal neurons in these distinct subregions.

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Section: Molecular Markersmentioning

confidence: 70%

Section: Molecular Markersmentioning

confidence: 97%

Functional Differentiation of Adult-Born Neurons along the Septotemporal Axis of the Dentate Gyrus: Figure 1.

Sahay

Duman

et al. 2015

Cold Spring Harb Perspect Biol

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“…Despite this, it remains the case that the absolute level of dopamine present in hippocampal tissue is quite low relative to the other monoamine transmitters. For example, one report of the levels of DA, norepinephrine, and 5-hydroxytryptamine in the CA1 region of ventral hippocampus indicates approximately 20-fold less DA than norepinephrine or 5-hydroxytryptamine (Hortnagl et al, 1991). Therefore, it is potentially significant that the dopamine receptor type we have identified as being likely to mediate the actions of cocaine on the IPSC is the D 3 receptor because it has the highest affinity for dopamine among all of the five members of the DA receptor family (at a K i of 25 nM, it has approximately 20-fold higher affinity than for the D 2 receptor type; Sokoloff et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

Dopamine-Mediated Disinhibition in the CA1 Region of Rat Hippocampus via D₃ Receptor Activation

Hammad

Wagner²

2005

J Pharmacol Exp Ther

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The hippocampal formation is thought to contribute to both addictive behaviors and to psychotic disorders, and the actions of the neurotransmitter dopamine are intimately involved with these disease states. We have used both whole-cell and extracellular recording techniques in hippocampal slices to investigate the actions of both cocaine and dopamine receptor agonists in the CA1 region. In the presence of cocaine (10 M), endogenously released dopamine decreased monosynaptic inhibitory postsynaptic currents (IPSCs) evoked from stratum radiatum but not from stratum oriens. This effect of cocaine was not blocked by the D 1/5 antagonist SCH 23390 ({R-(ϩ)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine}) (3 M), whereas several D 2 -like dopamine receptor antagonists prevented the cocaine-induced decrease in the IPSC. The most selective of the effective antagonists tested was the D 3 antagonist, U 99194 ({5,6-dimethoxy-indan-2-yl dipropylamine}) maleate (1 M). An exogenously applied D 3 -selective dopamine receptor agonist, PD 128907 ({(ϩ)-(4aR, 10bR)-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]-benzopyrano-[4,3-b]-1,4-oxazin-9-ol}) (1 M), also significantly inhibited the IPSC, providing further evidence that the activation of the D 3 subtype of dopamine receptor by endogenously released dopamine can modulate inhibition in the CA1 region. This disinhibitory action on pyramidal cells also increased synaptic excitability following Schaffer collateral stimulation, as demonstrated by either a decrease in paired-pulse inhibition of the population spike response or by an increase in the excitatory component of the mixed synaptic response evoked from stratum radiatum. These actions indicate that the activation of D 3 receptors by endogenously released dopamine, especially under conditions of transporter blockade, may significantly impact the processing of synaptic information through the stratum radiatum layer of the hippocampus.Functional imbalance of the dopamine neurotransmitter system in the brain is thought to be a key component underlying both schizophrenia and substance use disorders, and their comorbidity is increasingly being recognized in human populations (Negrete, 2003) and investigated using animal models (Chambers and Taylor, 2004). Data obtained from rats utilizing either the neonatal hippocampal lesion (schizophrenia) or self-administration (substance use) animal models have suggested that the hippocampus is likely to be involved in both schizophrenia (Harrison, 2004), and drug relapse (Vorel et al., 2001;Sun and Rebec, 2003). It is therefore important to determine the role of the endogenous dopamine transmitter system in normal and pathological hippocampal function.The understanding of the actions of dopamine as a neurotransmitter in the hippocampal formation has evolved over the past 3 decades, from the presumption that dopamine had no significant role (except as a precursor to norepinephrine), to the current appreciation that dopamine can act via multiple signaling pathways in ...

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“…From our present and previous studies, we observed that microglial activation in the DG occurred earlier than that in the CA1 region following transient cerebral ischemia. This difference might be related to the different types of ischemicinduced changes according to the hippocampal subregions after ischemia/reperfusion, and the regional heterogeneity of the hippocampus [9,13]. In addition, this difference might be due to the difference of microenvironment niche such as vascular or neurotrophic factor supply, because the DG is known as the active region in adult neurogenesis [28].…”

mentioning

confidence: 99%

Neuronal Degeneration and Microglial Activation in the Ischemic Dentate Gyrus of the Gerbil

Moon

Lee

Park

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. In the present study, we investigated the time-course changes of neuronal degeneration and microglial activation in the gerbil dentate gyrus after transient cerebral ischemia using Fluoro-Jade B histofluorescence staining and immunohistochemistry for Iba-1. Fluoro-Jade B positive cells were observed from 6 hr and markedly increased 1 day after ischemia/reperfusion. Iba-1-immunoreactive microglia were increased and hypertrophied at early time, and Iba-1 immunoreactivity was highest at 2 days after ischemia/reperfusion. These results may be direct evidence on neuronal degeneration and microglial activation in the gerbil dentate gyrus after ischemia/reperfusion.

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Regional heterogeneity in the distribution of neurotransmitter markers in the rat hippocampus

Cited by 115 publications

References 59 publications

Functional Differentiation of Adult-Born Neurons along the Septotemporal Axis of the Dentate Gyrus: Figure 1.

Functional Differentiation of Adult-Born Neurons along the Septotemporal Axis of the Dentate Gyrus: Figure 1.

Dopamine-Mediated Disinhibition in the CA1 Region of Rat Hippocampus via D₃ Receptor Activation

Neuronal Degeneration and Microglial Activation in the Ischemic Dentate Gyrus of the Gerbil

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Regional heterogeneity in the distribution of neurotransmitter markers in the rat hippocampus

Cited by 115 publications

References 59 publications

Functional Differentiation of Adult-Born Neurons along the Septotemporal Axis of the Dentate Gyrus: Figure 1.

Functional Differentiation of Adult-Born Neurons along the Septotemporal Axis of the Dentate Gyrus: Figure 1.

Dopamine-Mediated Disinhibition in the CA1 Region of Rat Hippocampus via D3 Receptor Activation

Neuronal Degeneration and Microglial Activation in the Ischemic Dentate Gyrus of the Gerbil

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Dopamine-Mediated Disinhibition in the CA1 Region of Rat Hippocampus via D₃ Receptor Activation