Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of female Wistar rats

Rodd-Henricks, Zachary A.; McKinzie, David L.; Crile, Robert S.; Murphy, James M.; McBride, William J.

doi:10.1007/s002139900347

Cited by 187 publications

(262 citation statements)

References 26 publications

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“…Data for these rats were not included in the statistical analyses. Cannula placements surrounding the VTA did not support ETOH self-administration (average number of active and inactive lever responses during acquisition were 872 and 772, respectively), which is in agreement with findings previously reported (Rodd et al, 2004b;Rodd-Henricks et al, 2000).…”

Section: Resultssupporting

confidence: 91%

“…Moreover, the self-infusion of ACD by P rats exhibits subregional heterogeneity similar to that observed for EtOH between the anterior and posterior VTA (Figure 2). In addition, ACD appears to be a 1000-fold more potent reinforcer than EtOH in the posterior VTA, a finding that is in agreement with previous results when data for Wistar and P rats were compared (Rodd-Henricks et al, 2000, 2002b. In vitro studies indicated that 45-225 mg% EtOH could generate up to 4 nmol/mg tissue wet wt/h of ACD (approximately 4 mM ACD).…”

Section: Discussionsupporting

confidence: 90%

“…Previous studies indicated that 150-300 mg% EtOH was self-infused into the posterior, but not anterior, VTA of Wistar rats (Rodd-Henricks et al, 2000). The present results indicate a similar subregional heterogeneity for EtOH selfadministration exists between the anterior and posterior VTA of P rats (Figure 2).…”

Section: Discussionsupporting

confidence: 76%

“…Shortening the surgical times and increasing the reproducibility of placements are important considerations when large numbers of animals are used, comparisons across groups are being conducted, and highly accurate placements are required. Most of our previous ICSA studies used female rats (Ikemoto et al, 1997a, b;Gatto et al, 1994;Rodd-Henricks et al, 2000, 2002a, b, 2003. Although not systematically studied, the estrous cycle did not appear to significantly alter self-administration behavior, as indicated by fairly stable responding across several sessions, when the same concentration of EtOH (RoddHenricks et al, 2003) or ACD (Rodd-Henricks et al, 2002b) was given.…”

Section: Animalsmentioning

confidence: 99%

“…Previous studies indicated that Wistar rats selfadministered 150-250 mg% EtOH directly into the posterior ventral tegmental area (VTA), whereas these concentrations were not self-infused into the anterior VTA (Rodd-Henricks et al, 2000). Furthermore, the intracranial self-administration (ICSA) of EtOH into the posterior VTA of Wistar rats was blocked with coinfusion of serotonin-3 (5-HT 3 ) receptor antagonists (Rodd-Henricks et al, 2003) or the DA D 2,3 agonist quinpirole (Rodd et al, 2004b), suggesting the involvement of local 5-HT 3 receptors and VTA-DA neurons in the reinforcing effects of EtOH.…”

Section: Introductionmentioning

confidence: 99%

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Regional Heterogeneity for the Intracranial Self-Administration of Ethanol and Acetaldehyde within the Ventral Tegmental Area of Alcohol-Preferring (P) Rats: Involvement of Dopamine and Serotonin

Rodd

Bell

Zhang

et al. 2004

Neuropsychopharmacol

138

175

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The meso-limbic dopamine (DA) system has an important role in regulating alcohol drinking. Previous findings from our laboratory indicated that Wistar rats self-administered ethanol (EtOH) directly into the posterior, but not anterior, ventral tegmental area (VTA), and that coadministration of a DA D 2,3 receptor agonist or a serotonin-3 (5-HT 3 ) receptor antagonist blocked EtOH self-administration. In addition, we reported that alcohol-preferring (P) rats self-administered acetaldehyde (ACD), the first metabolite of EtOH, into the posterior VTA. The objectives of this study were to compare the reinforcing effects of EtOH and ACD within the VTA of P rats to examine the possibility that the reinforcing effects of EtOH within the VTA may be mediated by its conversion to ACD. Adult female P rats were stereotaxically implanted with guide cannulae aimed at either the posterior or anterior VTA. At 1 week after surgery, rats were placed in standard two-lever (active and inactive) experimental chambers for a total of seven to eight sessions. The 4-h sessions were conducted every other day. The results indicated that (a) 75-300 mg% (17-66 mM) EtOH and 6-90 mM ACD were self-administered into the posterior, but not anterior, VTA; (b) the self-administration of 150 mg% EtOH was not altered by coinfusion of a catalase inhibitor; (c) coadministration of the D 2/3 agonist quinpirole (100 mM) blocked the self-infusions of 150 mg% EtOH and 23 mM ACD into the posterior VTA; and (d) coadministration of 200 mM ICS205,930 (5-HT 3 receptor antagonist) prevented the self-infusion of 150 mg% EtOH, whereas concentrations of ICS 205,930 up to 400 mM had no effect on the self-infusion of 23 mM ACD into the posterior VTA. Overall, the results of this study indicate that EtOH and ACD can independently produce reinforcing effects within the posterior VTA, and that activation of DA neurons mediates these effects. Furthermore, activation of 5-HT 3 receptors within the posterior VTA is involved in the self-infusion of EtOH, but not ACD.

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Section: Resultssupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 76%

Section: Animalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regional Heterogeneity for the Intracranial Self-Administration of Ethanol and Acetaldehyde within the Ventral Tegmental Area of Alcohol-Preferring (P) Rats: Involvement of Dopamine and Serotonin

Rodd

Bell

Zhang

et al. 2004

Neuropsychopharmacol

138

175

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Afferents to the GABAergic tail of the ventral tegmental area in the rat

Kaufling

Veinante

Pawlowski

et al. 2009

J of Comparative Neurology

283

330

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We previously showed that chronic psychostimulant exposure induces the transcription factor DeltaFosB in gamma-aminobutyric acid (GABA)ergic neurons of the caudal tier of the ventral tegmental area (VTA). This subregion was defined as the tail of the VTA (tVTA). In the present study, we showed that tVTA can also be visualized by analyzing FosB/DeltaFosB response following acute cocaine injection. This induction occurs in GABAergic neurons, as identified by glutamic acid decarboxylase (GAD) expression. To characterize tVTA further, we mapped its inputs by using the retrograde tracers Fluoro-Gold or cholera toxin B subunit. Retrogradely labeled neurons were observed in the medial prefrontal cortex, the lateral septum, the ventral pallidum, the bed nucleus of the stria terminalis, the substantia innominata, the medial and lateral preoptic areas, the lateral and dorsal hypothalamic areas, the lateral habenula, the intermediate layers of the superior colliculus, the dorsal raphe, the periaqueductal gray, and the mesencephalic and pontine reticular formation. Projections from the prefrontal cortex, the hypothalamus, and the lateral habenula to the tVTA were also shown by using the anterograde tracer biotinylated dextran amine (BDA). We showed that the central nucleus of the amygdala innervates the anterior extent of the VTA but not the tVTA. Moreover, the tVTA mainly receives non-aminergic inputs from the dorsal raphe and the locus coeruleus. Although the tVTA has a low density of dopaminergic neurons, its afferents are mostly similar to those targeting the rest of the VTA. This suggests that the tVTA can be considered as a VTA subregion despite its caudal location.

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Anterior and posterior parts of the rat ventral tegmental area and the rostromedial tegmental nucleus receive topographically distinct afferents from the lateral habenular complex

Petzel

Bernard

Poller

et al. 2017

J of Comparative Neurology

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That activation of the reward system involves increased activity of dopaminergic (DA) neurons in the ventral tegmental area (VTA) is widely accepted. In contrast, the lateral habenular complex (LHb), which is known as the center of the anti-reward system, directly and indirectly inhibits DA neurons in the VTA. The VTA, however, is not a homogenous entity. Instead, it displays major functional differences between its anterior (aVTA) and posterior (pVTA) regions. It is not precisely known, whether habenular input to the aVTA, pVTA, and the newly recognized rostromedial tegmental nucleus (RMTg) are similarly or differently organized. Consequently, the present investigation addressed the connections between LHb and aVTA, pVTA, and RMTg using retrograde and anterograde tracing techniques in the rat. Our experiments disclosed strictly reciprocal and conspicuously focal interconnections between LHbM (LHbMPc/LHbMC) and PN, as well as between RLi and LHbLO. In addition, we found that LHb inputs to the aVTA are dorsoventrally ordered. Dorsal parts of the aVTA receive afferents from LHbL and LHbM, whereas ventral parts of the aVTA are preferentially targeted by the LHbM. LHb afferents to the pVTA are distinct from those to the RMTg, given that the RMTg is primarily innervated from the LHbL, whereas pVTA receives afferents from LHbM and LHbL. These data indicate the existence of two separate pathways from the LHb to the VTA, a direct and an indirect one, which may subserve distinct biological functions.

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Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of female Wistar rats

Abstract: The findings suggest that EtOH is reinforcing within the posterior VTA of Wistar rats, and the VTA is a functionally heterogeneous structure with regard to EtOH reinforcement.

Cited by 187 publications

References 26 publications

Regional Heterogeneity for the Intracranial Self-Administration of Ethanol and Acetaldehyde within the Ventral Tegmental Area of Alcohol-Preferring (P) Rats: Involvement of Dopamine and Serotonin

Regional Heterogeneity for the Intracranial Self-Administration of Ethanol and Acetaldehyde within the Ventral Tegmental Area of Alcohol-Preferring (P) Rats: Involvement of Dopamine and Serotonin

Afferents to the GABAergic tail of the ventral tegmental area in the rat

Anterior and posterior parts of the rat ventral tegmental area and the rostromedial tegmental nucleus receive topographically distinct afferents from the lateral habenular complex

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