Regional grey matter volume abnormalities in bulimia nervosa and binge-eating disorder

Schäfer, Axel; Vaitl, Dieter; Schienle, Anne

doi:10.1016/j.neuroimage.2009.12.063

Cited by 107 publications

(134 citation statements)

References 25 publications

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“…The mOFC plays an important role in reward-value coding, and our results suggest that BTE patients displayed increased hedonic processing (Kringelbach, 2005). The present results extend previous findings from BTE patients revealing altered functional neuroanatomy of the mOFC specifically during the receipt of food reward (Uher et al, 2004;Schienle et al, 2009;Schafer et al, 2010). However, taste reward processing and taste reward-related learning in BN have been related to decreased activation of the lateral OFC, a brain region including the secondary taste area (Bohon and Stice, 2011;Frank et al, 2011).…”

Section: Discussionsupporting

confidence: 88%

Neural signature of food reward processing in bulimic-type eating disorders

Simon

Skunde

Walther

et al. 2016

Soc Cogn Affect Neurosci

100

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Clinical observations and similarities to addiction suggest heightened reward sensitivity to food in patients with bulimictype eating (BTE) disorders. Therefore, we investigated the expectation and receipt of food reward compared with monetary reward in patients with BTE. Fifty-six patients with BTE (27 patients with binge eating disorder and 29 with bulimia nervosa) and 55 matched healthy control participants underwent event-related functional magnetic resonance imaging while performing both food and monetary incentive delay tasks. BTE patients exhibited reduced brain activation in the posterior cingulate cortex during the expectation of food and increased activity in the medial orbitofrontal cortex, anterior medial prefrontal cortex and posterior cingulate cortex during the receipt of food reward. These findings were relevant to food because we found no significant group differences related to monetary reward. In the patients, higher brain activity in the medial orbitofrontal cortex during the receipt of food reward was related to higher levels of trait food craving and external eating. BTE patients exhibited increased hedonic processing during the receipt of food reward. These findings corroborate the notion that an altered responsiveness of the reward network to food stimuli is associated with BTE.

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Section: Discussionsupporting

confidence: 88%

Neural signature of food reward processing in bulimic-type eating disorders

Simon

Skunde

Walther

et al. 2016

Soc Cogn Affect Neurosci

100

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“…25 If these abnormalities are the consequences of regularly engaging in binge eating, it might not be until mid-to-late adulthood that such structural and functional changes translate to significant differences in one's neuropsychological functioning. In any case, it is important to note that, despite finding significant between-group differences in outcomes, both groups' mean scores in Svaldi et al's 19 study were in the normal range.…”

Section: Discussionmentioning

confidence: 99%

“…For example, Schafer et al 25 found greater gray matter volume in the medial orbitofrontal cortex of individuals with BED relative to a normal sample. The orbitofrontal cortex has been implicated in a number of cognitive and behavioral processes commonly engaged before, during, and after eating, including decisionmaking, inhibition, hunger, and satiety.…”

Section: Binge Eating and Behavioral Impulsivitymentioning

confidence: 99%

“…Findings from both self-report and neuroimaging studies suggest that individuals who engage in regular binge eating also demonstrate heightened sensitivity to reward and punishment, 25,32,96,97 which is hypothesized to translate to greater reactivity to distressing emotions. Individuals who experience difficult emotions and negative urgency more intensely might be more prone to binge eating as a means of coping with their feelings despite the potential physical (e.g., stomach discomfort, weight gain) and emotional (e.g., guilt, shame) consequences.…”

Section: Behavioral Impulsivity Outcomesmentioning

confidence: 99%

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Executive functioning and behavioral impulsivity of young women who binge eat

Kelly

Bulik

Mazzeo

2013

Intl J Eating Disorders

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Objective: To examine the link between binge eating, executive functioning, and behavioral impulsivity.Method: Fifty women who reported engaging in weekly binge eating in the absence of regular compensatory behaviors and 66 women with no history of binge eating completed several self-report questionnaires and a brief neuropsychological battery, including the Wisconsin Card Sorting Task and Conner's Continuous Performance Task.Results: Hierarchical regression analyses revealed that groups did not differ in executive functioning after controlling for depression, anxiety, body mass, general intelligence, and psychotropic medication use. Correlation analyses suggest that individuals who endorse more frequent binge eating might have greater difficulties thinking flexibly or shifting attention. Individuals who binge eats are also more likely to behave impulsively, but only for emotional reasons.Discussion: Although this study is unable to determine whether these cognitive and behavioral factors precede or follow binge-eating episodes, outcomes have implications for treatment and prevention. V V C 2013 by Wiley Periodicals, Inc.

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“…For example, Volkow et al (2003) found that higher emotional eating scores were associated with greater dopaminergic striatal responses to the taste and smell of food among lean adults, and in a study of lean and overweight adolescent girls Bohon et al (2009) found that those high in emotional eating showed greater parahippocampal gyrus and ACC activation in response to a cue signalling receipt of a milkshakeas well as greater activation in the ventral pallidum, ACC and thalamus when actually tasting the milkshake. Meanwhile, studies of binge eating have suggested that binge eaters show heightened responses to high-palatability food cues in the frontal premotor area (Geliebter et al, 2006), and medial OFC (Schienle et al, 2009), increased responses to the sight and smell of real cooked food in the frontal and prefrontal cortex (Karhunen et al, 2000), and caudate/putamen (increased dopamine activity) (Wang et al, 2011), and greater grey matter volume in the ACC and medial OFC (Schafer et al, 2010).…”

Section: Neuroimaging Studies Of Obesity and Appetitive Traitsmentioning

confidence: 99%

Fat brains, greedy genes, and parent power: A biobehavioural risk model of child and adult obesity

Carnell

Kim

Pryor

2012

International Review of Psychiatry

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We live in a world replete with opportunities to overeat highly calorifi c, palatable foods -yet not everyone becomes obese. Why? We propose that individuals show differences in appetitive traits (e.g. food cue responsiveness, satiety sensitivity) that manifest early in life and predict their eating behaviours and weight trajectories. What determines these traits? Parental feeding restriction is associated with higher child adiposity, pressure to eat with lower adiposity, and both strategies with less healthy eating behaviours, while authoritative feeding styles coincide with more positive outcomes. But, on the whole, twin and family studies argue that nature has a greater infl uence than nurture on adiposity and eating behaviour, and behavioural investigations of genetic variants that are robustly associated with obesity (e.g. FTO) confi rm that genes infl uence appetite. Meanwhile, a growing body of neuroimaging studies in adults, children and high risk populations suggests that structural and functional variation in brain networks associated with reward, emotion and control might also predict appetite and obesity, and show genetic infl uence. Together these different strands of evidence support a biobehavioural risk model of obesity development. Parental feeding recommendations should therefore acknowledge the powerful -but modifi able -contribution of genetic and neurological infl uences to children ' s eating behaviour.

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Regional grey matter volume abnormalities in bulimia nervosa and binge-eating disorder

Cited by 107 publications

References 25 publications

Neural signature of food reward processing in bulimic-type eating disorders

Neural signature of food reward processing in bulimic-type eating disorders

Executive functioning and behavioral impulsivity of young women who binge eat

Fat brains, greedy genes, and parent power: A biobehavioural risk model of child and adult obesity

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