Regional gray matter volume of dopaminergic system associate with creativity: Evidence from voxel-based morphometry

Takeuchi, Hikaru; Taki, Yasuyuki; Sassa, Yuko; Hashizume, Hiroshi; Sekiguchi, Atsushi; Fukushima, Ayako; Kawashima, Ryuta

doi:10.1016/j.neuroimage.2010.02.078

Cited by 227 publications

(232 citation statements)

References 78 publications

(100 reference statements)

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“…Default parameter settings were used (Gaser, 2007). To reduce the scanner-specific bias, we used a customized GM anatomical template and prior probability maps of gray and white matter images created from the T1-weighted structural images taken in our scanner in a previous study (Takeuchi et al, 2010c). Next, the T1-weighted structural images of each subject were segmented into gray and white matter partitions using the new gray and white matter prior probability maps.…”

Section: Methodsmentioning

confidence: 99%

Effects of Training of Processing Speed on Neural Systems

Taki²,

et al. 2011

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Processing speed (PS) training improves performance on untrained PS tasks in the elderly. However, PS training's effects on the PS of young adults and on neural mechanisms are still unknown. In humans, we investigated this issue using psychological measures, voxelbased morphometry, the n-back task [a typical task for functional magnetic resonance imaging (fMRI) studies with conditions of 0-back (simple cognitive processes) and 2-back tasks (working memory; WM)], resting-state fMRI for the analysis of functional connectivity between brain regions during rest (resting-FC), and intensive adaptive training of PS. PS training was associated with (1) significant or substantial improvement in the performance of PS measures, (2) changes in the gray matter structures of the left superior temporal gyrus and the bilateral regions around the occipitotemporal junction, (3) changes in functional activity that are related to simple cognitive processes (but not those of WM) in the left perisylvian region, and (4) increased resting-FC between the left perisylvian area and the area that extends to the lingual gyrus and calcarine cortex. These results confirm the PS-training-induced plasticity in PS and the traininginduced plasticity of functions and structures that are associated with speeded cognitive processes. The observed neural changes caused by PS training may give us new insights into how PS training, and possibly other cognitive training, can improve PS.

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Section: Methodsmentioning

confidence: 99%

Effects of Training of Processing Speed on Neural Systems

Taki²,

et al. 2011

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“…In addition, the right angular gyrus was associated positively with CAQ score whereas the left lateral orbitofrontal gyrus was associated negatively with the CAQ score. Takeuchi et al (2010b) also found positive correlations between regional gray matter volume (rGMV) and individual creativity (as assessed by S-A creativity test) in the right dorsolateral PFC (DLPFC), bilateral precuneus, bilateral caudate and right midbrain regions using voxel-based morphometry (VBM). Gansler et al (2011) subsequently found that creative performance on the figural TTCT to be positively related to the gray matter volume (GMV) of the right parietal lobe gray matter, which might be related to global attention and visuo-spatial processing.…”

Section: Introductionmentioning

confidence: 94%

Brain structure links trait creativity to openness to experience

Li¹,

Li²,

Huang³

et al. 2014

Social Cognitive and Affective Neuroscience

121

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Creativity is crucial to the progression of human civilization and has led to important scientific discoveries. Especially, individuals are more likely to have scientific discoveries if they possess certain personality traits of creativity (trait creativity), including imagination, curiosity, challenge and risk-taking. This study used voxel-based morphometry to identify the brain regions underlying individual differences in trait creativity, as measured by the Williams creativity aptitude test, in a large sample (n ¼ 246). We found that creative individuals had higher gray matter volume in the right posterior middle temporal gyrus (pMTG), which might be related to semantic processing during novelty seeking (e.g. novel association, conceptual integration and metaphor understanding). More importantly, although basic personality factors such as openness to experience, extroversion, conscientiousness and agreeableness (as measured by the NEO Personality Inventory) all contributed to trait creativity, only openness to experience mediated the association between the right pMTG volume and trait creativity. Taken together, our results suggest that the basic personality trait of openness might play an important role in shaping an individuals trait creativity.

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“…Searching for structural brain-behavior correlation with this approach is often performed by introducing several regressors (or predictors) in addition to the behavioral measure of interest (X) in the design matrix, such as age, gender, TBV, and a behavioral measure of general cognitive functioning (e.g. (Takeuchi et al 2010(Takeuchi et al , 2013Genon et al 2014)). …”

Section: Limitations Of the Voi Approachmentioning

confidence: 99%

Searching for behavior relating to grey matter volume in a-priori defined right dorsal premotor regions: Lessons learned

et al. 2017

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(max 250 words)Recently, we showed that the functional heterogeneity of the right dorsal premotor (PMd) cortex could be better understood by dividing it into five subregions that showed different behavioral associations according to task-based activations studies. The present study investigated whether the revealed behavioral profile could be corroborated and complemented by a structural brain behavior correlation approach in two healthy adults cohorts.Grey matter volume within the five volumes of interest (VOI-GM) was computed using voxelbased morphometry. Associations between the inter-individual differences in VOI-GM and performance across a range of neuropsychological tests were assessed in the two cohorts with and without correction for demographical variables. Additional analyses were performed in random smaller subsamples drawn from each of the two cohorts.In both cohorts, correlation coefficients were low; only few were significant and a considerable number of correlations were counterintuitive in their directions (i.e., higher performance related to lower GMV). Furthermore, correlation patterns were inconsistent between the two cohorts.Subsampling revealed that correlation patterns could vary widely across small samples and that negative correlations were as likely as positive correlations.Thus, the structural brain/behavior approach did not corroborate the functional profiles of the PMd subregions inferred from activation studies, suggesting that local recruitment by fMRI studies does not necessarily imply covariance of local structure with behavioral performance in healthy adults.We discuss the limitations of such studies and related recommendations for future studies.

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Regional gray matter volume of dopaminergic system associate with creativity: Evidence from voxel-based morphometry

Cited by 227 publications

References 78 publications

Effects of Training of Processing Speed on Neural Systems

Effects of Training of Processing Speed on Neural Systems

Brain structure links trait creativity to openness to experience

Searching for behavior relating to grey matter volume in a-priori defined right dorsal premotor regions: Lessons learned

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