Regional gray matter volume correlates to physical and mental fatigue in healthy middle-aged adults

Putra, Handityo Aulia; Park, Kaechang; Yamashita, Fumio; Mizuno, Kei; Watanabe, Yasuyoshi

doi:10.1016/j.ynirp.2022.100128

Cited by 4 publications

(5 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If these volumetric alterations represent hyperactivity or hypoactivity of neuronal functions, the mixed responses to inattention and hyperactive motor traits might indicate more intricate interactions between these grey matter regions. This aligns with previous research on fatigue, which demonstrated mixed positive and negative correlations between fatigue levels and rGMVs in healthy middle-aged adults 31 . In cases of chronic or pathological fatigue, rGMVs decrease 49 .…”

Section: Discussionsupporting

confidence: 92%

“…In a previous work, a significant correlation was found between the volume of the right SMC and the degrees of both physical and mental fatigue in healthy middle-aged adults 31 . This observation was based on a large-scale analysis of GMV data collected during Brain Dock, which has been developed and prevalent in Japan as MRI-based brain health check-ups 32 .…”

Section: Introductionmentioning

confidence: 75%

See 1 more Smart Citation

Adult attention-deficit/hyperactivity disorder traits in healthy adults associated with brain volumetric data identify precuneus involvement in traffic crashes

Putra,

Park,

Oba

et al. 2023

Sci Rep

Self Cite

View full text Add to dashboard Cite

This large-scale study including 2548 healthy adults with no clinical attention-deficit/hyperactivity disorder (ADHD) diagnosis intended to clarify the complex relationships between cerebral grey matter volumes (GMVs), ADHD traits, and driving safety behaviours. Path analysis of magnetic resonance imaging (MRI) results and questionnaires about ADHD traits and traffic crashes over the past decade revealed significant correlations of ADHD traits with different brain regions relevant to different cognitive functions. The left precuneus responsible for visuospatial cognition was the sole region correlated with all ADHD trait categories, suggesting it plays an important role in understanding driving safety and traffic crashes. For the first time, a strong relationship was found among regional GMVs, ADHD traits, and real-life traffic crashes. These insights into the complex interplay may inform the development of an effective intervention with MRI examination to prevent traffic crashes. Large-scale brain volumetric data may further open social applications of behaviour science and neuroimaging.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 75%

Adult attention-deficit/hyperactivity disorder traits in healthy adults associated with brain volumetric data identify precuneus involvement in traffic crashes

Putra,

Park,

Oba

et al. 2023

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…It may alternatively be involved in a biological defense reaction. We previously examined the relationship between fatigue perception intensity and regional GM volumes in healthy subjects and found that there are regions where GM volume increases for compensation as fatigue increases 25 . In any case, there is no doubt that the relationship between DSB and GM region is more complex than expected.…”

Section: Discussionmentioning

confidence: 99%

Uniformly positive or negative correlation of cerebral gray matter regions with driving safety behaviors of healthy older drivers

Park,

Putra,

Yoshida

et al. 2024

Sci Rep

Self Cite

View full text Add to dashboard Cite

This study investigated the relationship between cerebral gray matter (GM) regions and driving safety behaviors (DSBs) of 98 older drivers without dementia (mean age, 77.72 ± 3.677 years). Their DSBs were evaluated on actual vehicles running on a closed-circuit course. The DSB was scored in six categories: DSB1, visual search behavior; DSB2, speeding; DSB3, signaling of the indicator; DSB4, vehicle stability; DSB5, positioning; and DSB6, steering. The scores were calculated by a single driving instructor; larger scores indicated safer driving performances. Regional GM volumes were measured with voxel-based morphometry by magnetic resonance imaging (MRI). Out of 56 GM regions, 18 were correlated with DSB categories except for DSB4. When a single GM region was correlated with multiple DSB categories, a positive or negative response was uniformly determined for the respective region despite clear differences in the DSB categories. This result suggests the possible existence of two contradictory mechanisms in the brain for DSB. The left postcentral gyrus may largely function in regulating DSBs because it was negatively correlated with five of six DSB categories. Thus, MRI’s measurement of regional GM volumes may help deepen the understanding of the diversity and complexity inherent in brain functions for DSBs.

show abstract

“…Given the prominent role of the putamen in habit formation ( Singer, 2013 ; Yin, Knowlton, & Balleine, 2004 ), it was surprising that this relationship was not found in the sample with ED. However, a recent study showed a positive correlation between physical fatigue and left putamen volume in healthy middle-aged adults ( Putra, Park, Yamashita, Mizuno, & Watanabe, 2022 ). The increase in putamen volume has been interpreted as compensation to counteract the development of fatigue.…”

Section: Discussionmentioning

confidence: 99%

Brain alterations in individuals with exercise dependence: A multimodal neuroimaging investigation

Schaub,

Meyer,

Tschopp

et al. 2024

JBA

View full text Add to dashboard Cite

BackgroundExercise dependence (ED) is characterised by behavioural and psychological symptoms that resemble those of substance use disorders. However, it remains inconclusive whether ED is accompanied by similar brain alterations as seen in substance use disorders. Therefore, we investigated brain alterations in individuals with ED and inactive control participants.MethodsIn this cross-sectional neuroimaging investigation, 29 individuals with ED as assessed with the Exercise Dependence Scale (EDS) and 28 inactive control participants (max one hour exercising per week) underwent structural and functional resting-state magnetic resonance imaging (MRI). Group differences were explored using voxel-based morphometry and functional connectivity analyses. Analyses were restricted to the striatum, amygdala, and inferior frontal gyrus (IFG). Exploratory analyses tested whether relationships between brain structure and function were differently related to EDS subscales among groups.ResultsNo structural differences were found between the two groups. However, right IFG and bilateral putamen volumes were differently related to the EDS subscales “time” and “tolerance”, respectively, between the two groups. Resting-state functional connectivity was increased from right IFG to right superior parietal lobule in individuals with ED compared to inactive control participants. Furthermore, functional connectivity of the angular gyrus to the left IFG and bilateral caudate showed divergent relationships to the EDS subscale “tolerance” among groups.DiscussionThe findings suggest that ED may be accompanied by alterations in cognition-related brain structures, but also functional changes that may drive compulsive habitual behaviour. Further prospective studies are needed to disentangle beneficial and detrimental brain effects of ED.

show abstract

Regional gray matter volume correlates to physical and mental fatigue in healthy middle-aged adults

Cited by 4 publications

References 44 publications

Adult attention-deficit/hyperactivity disorder traits in healthy adults associated with brain volumetric data identify precuneus involvement in traffic crashes

Adult attention-deficit/hyperactivity disorder traits in healthy adults associated with brain volumetric data identify precuneus involvement in traffic crashes

Uniformly positive or negative correlation of cerebral gray matter regions with driving safety behaviors of healthy older drivers

Brain alterations in individuals with exercise dependence: A multimodal neuroimaging investigation

Contact Info

Product

Resources

About