Regional Glymphatic Dysfunction is linked to Spinocerebellar Ataxia Type 3 pathophysiology
Lin Hua,
Manxi Xu,
Linwei Zhang
et al.
Abstract:Spinocerebellar ataxia type 3 (SCA3) involves neuroinflammation and imbalance between production and clearance of proteins which affects the glymphatic system, the lymphatic-like, fluid-transport system in the brain. However, it is unclear whether SCA3 is related to impairments in glymphatic function. Using multimodal imaging data, 34 SCA3 patients and 36 age-, sex- and educational matched healthy controls (HCs) were compared using multiple glymphatic measurements, including choroid plexus (CP) and cerebrospin… Show more
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