Regional Genetic Architecture of the Corpus Callosum and its Overlap with Psychiatric and Substance Use Phenotypes
Megan L. Campbell,
Alexey Shadrin,
Dennis van der Meer
et al.
Abstract:BackgroundThe corpus callosum (CC) is a brain structure with a high heritability and a potential role in psychiatric and substance use traits. However, the genetic relationship of the CC, and its subregions, with psychiatric phenotypes remains largely unclear. We aimed to investigate the genetic architecture of the CC and its subregions and its overlap with psychiatric phenotypes using causal mixture model analysis.MethodsWe employed summary statistics from genome-wide association studies (GWAS) of the CC (n=3… Show more
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