Regional Fluorodeoxyglucose Metabolism and Instrumental Activities of Daily Living across the Alzheimer's Disease Spectrum

Roy, Kamolika; Pepin, Lesley; Philiossaint, Marlie; Lorius, Natacha; Becker, J. Alex; Locascio, Joseph J.; Rentz, Dorene M.; Sperling, Reisa A.; Johnson, Keith A.; Marshall, Gad A.

doi:10.3233/jad-131796

Cited by 34 publications

(29 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FDG-PET data were acquired as described previously [11]. A bolus of 5 mCi of 18 F-FDG was injected, in a quiet, dimly lit room, with subjects in the eyes-open state.…”

Section: Methodsmentioning

confidence: 99%

Decreased hippocampal metabolism in high‐amyloid mild cognitive impairment

Hanseeuw

Schultz

Betensky

et al. 2016

Alzheimer's & Dementia

Self Cite

View full text Add to dashboard Cite

INTRODUCTION Hippocampal volume, cortical metabolism and thickness are decreased in mild cognitive impairment (MCI). Hippocampal metabolism studies comparing MCI and clinically normal (CN) elderly gave inconsistent results. As hippocampus is a key region in Alzheimer’s disease, we hypothesized that hippocampal metabolism is specifically decreased in high-amyloid MCI. METHODS 250CN and 45MCI underwent 3D-MRI, FDG-PET, and PIB-PET. We investigated the interaction between clinical and amyloid status on hippocampal metabolism, hippocampal volume, cortical metabolism and thickness using linear models, covarying age, gender, and education. Analyses were conducted with and without correction for multiple comparisons and for partial volume effects. RESULTS Volume-adjusted hippocampal metabolism was decreased in high-amyloid MCI but close to normal in low-amyloid MCI and in high-amyloid CN. Both MCI groups had hippocampal atrophy, although less severe in low-amyloid MCI. High-amyloid CN and high-amyloid MCI had cortical hypometabolism. DISCUSSION Hippocampal metabolism is decreased when both cognitive impairment and amyloid are present.

show abstract

“…FDG-PET data were acquired as described previously [11]. A bolus of 5 mCi of 18 F-FDG was injected, in a quiet, dimly lit room, with subjects in the eyes-open state.…”

Section: Methodsmentioning

confidence: 99%

Decreased hippocampal metabolism in high‐amyloid mild cognitive impairment

Hanseeuw

Schultz

Betensky

et al. 2016

Alzheimer's & Dementia

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the other hand, these items might be useful in combination with other items derived from similar analyses in preclinical and prodromal AD clinical trials, which consist of similar samples, as sensitive IADL outcome measures. IADL impairment in individuals across the early AD spectrum, including CN, MCI, and mild AD dementia, has been associated with multiple AD biomarkers, including measures of atrophy, hypometabolism, cortical amyloid, and cerebrospinal fluid amyloid-beta 1-42, total tau, and phospho-tau [28-33]. The current study did not include AD biomarkers in the classification of diagnoses (the classification was based solely on clinical information).…”

Section: Discussionmentioning

confidence: 99%

SIST-M-IR Activities of Daily Living Items that Best Discriminate Clinically Normal Elderly from those with Mild Cognitive Impairment

Zoller¹,

Gaal²,

Royer³

et al. 2014

CAR

View full text Add to dashboard Cite

Background Activities of daily living (ADL) impairment is a hallmark of Alzheimer's disease (AD) dementia, but impairment in instrumental ADL (IADL) has been reported in mild cognitive impairment (MCI). The Structured Interview and Scoring Tool-Massachusetts Alzheimer's Disease Research Center (MADRC)-Informant Report (SIST-M-IR) includes 60 graded items that assist in scoring the Clinical Dementia Rating; it assesses the spectrum of cognitive and ADL changes relevant to early AD. Of the 60 SIST-M-IR items, 41 address IADL; we aimed to determine which of these best discriminate individuals with MCI from clinically normal (CN) elderly. Methods We assessed 447 subjects participating in the MADRC longitudinal cohort (289 CN, 158 MCI). We performed logistic regression analyses predicting the probability of CN vs. MCI diagnosis using the SIST-M-IR items. Analyses were adjusted for demographic characteristics. Results We found that 4 SIST-M-IR items best discriminated between CN and MCI subjects (MCI performing worse than CN): “participating in games that involve retrieving words” (p=0.0001), “navigating to unfamiliar areas” (p=0.001), “performing mental tasks involved in a former primary job” (p=0.002), and “fixing things or finishing projects” (p=0.002). Conclusions Our results point to the earliest functional changes seen in elderly at risk for AD, which could be captured by a few simple questions. Honing the sensitivity of clinical assessment tools will help clinicians differentiate those individuals with normal aging from those who are developing cognitive impairment.

show abstract

“…Cortical thickness of regions of interest (ROI) was measured using FreeSurfer Version 5.1 (http://surfer.nmr.mgh.harvard.edu/) [19]. Four ROI chosen based on results of prior analyses of neuroimaging correlates of ADL were assessed [20, [21]: 1) inferior temporal cortex 2) posterior cingulate cortex; 3) medial orbitofrontal cortex; and 4) supramarginal cortex.…”

Section: Methodsmentioning

confidence: 99%

The Harvard Automated Phone Task: New Performance-Based Activities of Daily Living Tests for Early Alzheimer’s Disease

et al. 2015

View full text Add to dashboard Cite

Background: Impairment in activities of daily living is a major burden for Alzheimer’s disease dementia patients and caregivers. Multiple subjective scales and a few performance-based instruments have been validated and proven to be reliable in measuring instrumental activities of daily living in Alzheimer’s disease dementia but less so in amnestic mild cognitive impairment and preclinical Alzheimer’s disease. Objective: To validate the Harvard Automated Phone Task, a new performance-based activities of daily living test for early Alzheimer’s disease, which assesses high level tasks that challenge seniors in daily life. Design: In a cross-sectional study, the Harvard Automated Phone Task was associated with demographics and cognitive measures through univariate and multivariate analyses; ability to discriminate across diagnostic groups was assessed; test-retest reliability with the same and alternate versions was assessed in a subset of participants; and the relationship with regional cortical thickness was assessed in a subset of participants. Setting: Academic clinical research center. Participants: One hundred and eighty two participants were recruited from the community (127 clinically normal elderly and 45 young normal participants) and memory disorders clinics at Brigham and Women’s Hospital and Massachusetts General Hospital (10 participants with mild cognitive impairment). Measurements: As part of the Harvard Automated Phone Task, participants navigated an interactive voice response system to refill a prescription (APT-Script), select a new primary care physician (APT-PCP), and make a bank account transfer and payment (APT-Bank). The 3 tasks were scored based on time, errors, and repetitions from which composite z-scores were derived, as well as a separate report of correct completion of the task. Results: We found that the Harvard Automated Phone Task discriminated well between diagnostic groups (APT-Script: p=0.002; APT-PCP: p<0.001; APT-Bank: p=0.02), had an incremental level of difficulty, and had excellent test-retest reliability (Cronbach’s α values of 0.81 to 0.87). Within the clinically normal elderly, there were significant associations in multivariate models between performance on the Harvard Automated Phone Task and executive function (APT-PCP: p<0.001), processing speed (APT-Script: p=0.005), and regional cortical atrophy (APT-PCP: p=0.001; no significant association with APT-Script) independent of hearing acuity, motor speed, age, race, education, and premorbid intelligence. Conclusions: Our initial experience with the Harvard Automated Phone Task, which consists of ecologically valid, easily-administered measures of daily activities, suggests that these tasks could be useful for screening and tracking the earliest functional alterations in preclinical and early prodromal AD.

show abstract

Regional Fluorodeoxyglucose Metabolism and Instrumental Activities of Daily Living across the Alzheimer's Disease Spectrum

Cited by 34 publications

References 33 publications

Decreased hippocampal metabolism in high‐amyloid mild cognitive impairment

Decreased hippocampal metabolism in high‐amyloid mild cognitive impairment

SIST-M-IR Activities of Daily Living Items that Best Discriminate Clinically Normal Elderly from those with Mild Cognitive Impairment

The Harvard Automated Phone Task: New Performance-Based Activities of Daily Living Tests for Early Alzheimer’s Disease

Contact Info

Product

Resources

About