Regional expression of the ADAMs in developing chicken cochlea

Yan, Xin; Lin, Juntang; Wang, Hong; Markus, Annett; Wree, Andreas; Rolfs, Arndt; Luo, Jiankai

doi:10.1002/dvdy.22360

Cited by 10 publications

(26 citation statements)

References 62 publications

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“…Fox example, ADAM9 is transcribed in homogene cells, which play a role in the formation of the tectorial membrane. ADAM10 and ADAM17 are expressed by hair cells, while ADAM22 is found in spindle‐shape cells from E11 (Yan et al. 2010).…”

Section: Discussionmentioning

confidence: 99%

Regional expression of ADAM19 during chicken embryonic development

et al. 2011

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ADAM19 (also named meltrin b) is a member of the ADAM (a disintegrin and metalloprotease) family of metalloproteases and is involved in morphogenesis and tissue formation during embryonic development. In the present study, chicken ADAM19 is cloned by reverse transcription-polymerase chain reaction and identified by sequencing. Its expression patterns in different parts of the developing chicken embryo are investigated by Western blot analysis and immunohistochemistry. Results show that ADAM19 protein is widely expressed in chicken embryos. It is detectable in the central nervous system, including the brain, spinal cord, cochlea, and retina. Furthermore, ADAM19 protein is also found in other tissues and organs such as digestive organs, the thymus, the lung bud, the dorsal aorta, the kidney, the gonad, muscles, and in the feather buds. All these data suggest that ADAM19 plays an important role in the embryonic development of chicken.

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Section: Discussionmentioning

confidence: 99%

Regional expression of ADAM19 during chicken embryonic development

et al. 2011

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“…Jorissen et al (2010) reported that absence of ADAM10 in mouse induces a premature differentiation of neural progenitor cells into postmitotic neurons in the neocortex. Furthermore, the expression of the ADAMs including ADAM9, ADAM10, ADAM17, ADAM19, ADAM22 and ADAM23 are spatiotemporally expressed in the differentiating sensory neurons of dorsal root ganglia and acoustic ganglion cells of the cochlea Yan et al 2010Yan et al , 2011.…”

Section: Expression Of Adams In the Equatorial Lens Epithelium And Lementioning

confidence: 99%

“…Our previous studies showed that several ADAMs are expressed in the developing chicken brain, spinal cord and cochlea (Lin et al 2008Yan et al 2010). However, little is known about the expression of ADAMs during lens development.…”

Section: Introductionmentioning

confidence: 98%

“…Individual members of the ADAMs show variable expression patterns regulated spatiotemporally during embryonic development in several organ's systems (Edwards et al 2008;Lin et al 2008;Alfandari et al 2009), e.g., in the nervous system and in neural crest cell-derived structures (Goldsmith et al 2004;Lin et al 2008Lin et al , 2010Yan et al 2010), in skeletal muscle and bones (Yagami-Hiromasa et al 1995;Lewis et al 2004;Lin et al 2007;Yan et al 2011), in digestive organs and in the kidney and the heart (Hall and Erickson 2003;Lin et al 2007;Yan et al 2011). Functionally, the ADAMs are involved in cell-cell and/or cell-matrix interactions and mediate potentially protease activities, cell adhesion and cell signal transduction (Blobel 2005;Maretzky et al 2005;Edwards et al 2008;Alfandari et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Expression patterns of ADAMs in the developing chicken lens

Yan¹,

Lin

Rolfs³

et al. 2012

J Mol Hist

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In the present study the expression patterns of ADAM (a disintegrin and metalloprotease) genes in the chicken developing lens were analyzed. Using in situ hybridization, we found that seven members of the ADAM family including ADAM9, ADAM10, ADAM12, ADAM13, ADAM17, ADAM22, and ADAM23 are expressed in the developing embryonic lens. From embryonic incubation day (E) 2 to E3, most of the ADAMs investigated here are expressed in the lens placode and lens vesicle. From E5 to E7, all seven ADAMs, but predominantly ADAM9 and ADAM10, are throughly expressed in the central epithelium, as well as in the proliferating lens epithelium and the equatorial lens epithelium. From E9 to E14, expression of ADAM9, ADAM10, and ADAM17 decreases moderately in these regions. ADAM12 and ADAM13 are weakly expressed in the central epithelium and the lens epithelium, and are not detectable from E14 onward. ADAM22 and ADAM23 are expressed in the central epithelium, the lens epithelium and the equatorial lens epithelium at E5 and decrease gradually afterwards in the same regions. At E16, only weak ADAM9, ADAM10 and ADAM17 signals are found in the anterior lens epithelium. The changing spatiotemporal expression of the seven ADAMs suggests a regulatory role for these molecules during chicken lens development.

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“…Our previous study has shown that the seven ADAMs, including ADAM9, ADAM10, ADAM12, ADAM13, ADAM17, ADAM22 and ADAM23, are expressed in the developing chicken cochlea at later stage from embryonic day (E) 11 to E18 (Yan et al . ). However, little is known about the expression of these ADAMs at the early stages of the developing cochlea.…”

Section: Introductionmentioning

confidence: 97%

Expression patterns of the ADAMs in early developing chicken cochlea

et al. 2013

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Members of the ADAM (a disintegrin and metalloprotease) family are type I transmembrane proteins involved in biological processes of proteolysis, cell adhesion, cell-matrix interaction, as well as in the intracellular signaling transduction. In the present study, expression patterns of seven members of the ADAM family were investigated at the early stages of the developing cochlea by in situ hybridization. The results show that each individual ADAM is expressed and regulated in the early developing cochlea. ADAM9, ADAM10, ADAM17, and ADAM23 are initially and widely expressed in the otic vesicle at embryonic day 2.5 (E2.5) and in the differential elements of the cochlear duct at E9, while ADAM12 is expressed in acoustic ganglion cells at E7. ADAM22 is detectable in cochlear ganglion cells as early as from E4 and in the basilar papilla from E7. Therefore, the present study extends our previous results and suggests that ADAMs also play a role in the early cochlear development.

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Regional expression of the ADAMs in developing chicken cochlea

Cited by 10 publications

References 62 publications

Regional expression of ADAM19 during chicken embryonic development

Regional expression of ADAM19 during chicken embryonic development

Expression patterns of ADAMs in the developing chicken lens

Expression patterns of the ADAMs in early developing chicken cochlea

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