Regional expression of c-fos antigen in the basal forebrain following intraventricular infusions of angiotensin and its modulation by drinking either water or saline

Herbert, J.; Forsling, Mary L.; Howes, Simon R.; Stacey, Peter; Shiers, H. M.

doi:10.1016/0306-4522(92)90526-8

Cited by 119 publications

(36 citation statements)

References 43 publications

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“…This suggestion is consistent with the role of these areas in the control of thirst and vasopressin secretion (18,19,27). Hydration also inhibits ANG II-induced Fos-ir in the SON (50), but hardly induces any change in the other areas (16). Thus the reversal of Fos-ir, either partially in the OVLT and MnPO or totally in the SON, possibly depends on the reversal of more than one signal or on interactions between signals.…”

Section: Discussionsupporting

confidence: 70%

Water deprivation-induced sodium appetite: humoral and cardiovascular mediators and immediate early genes

Luca

Schoorlemmer

et al. 2002

American Journal of Physiology-Regulatory, Integrative and Comp

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. Water deprivation-induced sodium appetite: humoral and cardiovascular mediators and immediate early genes. Am J Physiol Regulatory Integrative Comp Physiol 282: R552-R559, 2002; 10.1152/ ajpregu.00295.2000. Adult rats deprived of water for 24-30 h were allowed to rehydrate by ingesting only water for 1-2 h. Rats were then given access to both water and 1.8% NaCl. This procedure induced a sodium appetite defined by the operational criteria of a significant increase in 1.8% NaCl intake (3.8 Ϯ 0.8 ml/2 h; n ϭ 6). Expression of Fos (as assessed by immunohistochemistry) was increased in the organum vasculosum of the lamina terminalis (OVLT), median preoptic nucleus (MnPO), subfornical organ (SFO), and supraoptic nucleus (SON) after water deprivation. After rehydration with water but before consumption of 1.8% NaCl, Fos expression in the SON disappeared and was partially reduced in the OVLT and MnPO. However, Fos expression did not change in the SFO. Water deprivation also 1) increased plasma renin activity (PRA), osmolality, and plasma Na ϩ ; 2) decreased blood volume; and 3) reduced total body Na ϩ ; but 4) did not alter arterial blood pressure. Rehydration with water alone caused only plasma osmolality and plasma Na ϩ concentration to revert to euhydrated levels. The changes in Fos expression and PRA are consistent with a proposed role for ANG II in the control of the sodium appetite produced by water deprivation followed by rehydration with only water. salt intake; hypovolemia; circumventricular organs; dehydration; thirst MODELS OF NA ϩ INGESTION based on selective depletion of the extracellular fluid compartment have revealed several potential mechanisms that control Na ϩ ingestion. These models typically employ combinations of Na ϩ deprivation and depletion to induce hypovolemia. In the rat, Na ϩ ingestion after Na ϩ loss in these models is associated with increased levels of circulating ANG II and aldosterone (9), unloading of baroreceptors (20), and inhibition of oxytocin secretion by dilution of body fluids after the Na ϩ -depleted animals have ingested water (42). Water deprivation is another procedure associated with an increased preference for ingesting NaCl solutions (48). During water deprivation, the obligatory excretion of water coupled with increased natriuresis results in dehydration of both the intracellular and extracellular fluid compartments (21,25,35). Like selective extracellular depletion models of Na ϩ ingestion, water deprivation reduces blood volume and increases plasma renin activity (PRA) and levels of circulating ANG II (8,29,30,35). However, in contrast to the selective extracellular dehydration models, water deprivation is accompanied by reductions, or no changes, in plasma levels of aldosterone (29,34) and by increases in plasma Na ϩ concentration ([Na ϩ ]) and osmolality (29,34,35 ] and osmolality levels are reduced after dehydrated animals drink water.Water-deprived animals clearly prefer to drink water, but there is also considerable ingestion of hypertonic saline solutions wh...

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Section: Discussionsupporting

confidence: 70%

Water deprivation-induced sodium appetite: humoral and cardiovascular mediators and immediate early genes

Luca

Schoorlemmer

et al. 2002

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Testing the animals during their inactive phase has the advantage that those neuronal systems which are required to perform the task are primarily activated. This minimizes the number of other neuronal populations that unequivocally would have been activated during the more active phase, such as brain areas implicated in eating, drinking, and general motor activity (Herbert et al 1992;Wang et al 1996;Nagahara and Handa 1997;Horn and Friedman 1998;Rhodes et al 2003;Sinnayah et al 2003). However, as a consequence the investigation duration during sampling is lower compared to sessions held during the more active phase of the animals.…”

Section: Social Recognition and Protein Synthesis In Micementioning

confidence: 99%

Social recognition memory requires two stages of protein synthesis in mice

Richter¹,

Wolf²,

Engelmann³

2005

Learn. Mem.

101

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Olfactory recognition memory was tested in adult male mice using a social discrimination task. The testing was conducted to begin to characterize the role of protein synthesis and the specific brain regions associated with activity in this task. Long-term olfactory recognition memory was blocked when the protein synthesis inhibitor anisomycin was injected 20 min before, immediately after, or 6 h after sampling. No effect was observed when anisomycin was administered 3 h or 18 h after sampling. Immunohistochemical analysis of Fos expression revealed that sampling-like exposure to a juvenile increased the activity of a subset of cells in the accessory olfactory bulb and the brain areas that are associated with it. Additionally, increased Fos expression was measured in the main olfactory bulb and the piriform cortex, whereas no signs of activation were seen in the cortical nucleus of the amygdala, all components of the main olfactory system. No increases in Fos immunoreactivity were observed after 4 h. Our data suggest that long-lasting olfactory recognition memory requires two stages of protein synthesis. The first stage takes place within 1–2 h and the second stage between 6–7 h after sampling. The first but not the second stage is paralleled by an increase in the number of Fos-immunoreactive cells in brain areas associated with both the main and accessory olfactory systems. It therefore appears that the role of the second stage of protein synthesis in recognition memory depends on the integrity of the first stage of protein synthesis

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“…Therefore ET administered into the ventricle in our experiments was considered to be actively concentrated in the proper hypothalamic region under a physiological condition. The ET injection dose for obtaining immunoreactivity of c-Fos was similar to that of other bioactive substances (vasopressin [1], angiotensin II [7,12] …”

Section: Discussionmentioning

confidence: 84%

“…In the case of angiotensin II [7] or cholecystokinin [20], ligand-induced c-Fos immunoreactivity reached a peak at 1.5 hr to 2 hr after the injection. This time course pattern was like that in the case of ET injection.…”

Section: And Cholecystokininmentioning

confidence: 97%