Regional Experience of Cervical Cancer Prevention in the Republic of Sakha   (Yakutia)

Афанасьева, Л. Н.; Игнатьева, М. Е.; Лялина, Л. В.; Саввина, Н В; Сметанина, В. Д.

doi:10.15789/2220-7619-2014-2-137-142

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…При генотипировании вируспозитивных образцов было установлено, что в Томской области ВПЧ 16 встречается в 78,1% случаев, что согласуется с мировыми данными и ранее полученными результатами относительно распространенности данного типа ВПЧ в Томском регионе [8,9]. Крупное исследование, охватившее 1624 случая заболевания РШМ в Республике Саха (Якутия) (регион с повышенными показателями заболеваемости и смертности от данного типа онкопатологии), показало, что ВПЧ 16 встречается в 72,2% случаев [10]. В Томской области 2-е и 3-е место занимает ВПЧ типов 33 и 31 (11,9 и 10,4% соответственно) (табл.…”

Section: Introductionunclassified

Integrative and episomal forms of genotype 16 of human papillomavirus in patients with cervical intraepithelial neoplasia and cervical cancer

Константиновна

Цыганов

Karabut

et al. 2016

Problems of Virology

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The study involved 500 patients with LSIL (low grade squamous intraepithelial lesion), HSIL (high grade squamous intraepithelial lesion), stage I-IV cervical cancer, infected with human papillomavirus (HPV), as well as 235 women without pathological changes in cervical mucosa. The comprehensive survey included colposcopy, cytological and histological analysis, detection and genotyping of high-risk human papillomavirus. Viral load and physical status of HPV16 DNA was evaluated in cases of mono-infection (n = 148). The prevalence of virus-positive cases among the patients with LSIL/NSIL, cervical cancer patients and healthy women was 69.2%, 76.7% and 51.9%, respectively. An association between the severity of disease and high viral load was revealed. The frequency of integrated DNA was strongly increased in patients with a high viral load. The frequency of episomal forms was either reduced or not detecteable in patients with high viral load as compared to patients with low viral load. It is reasonable to suggest that a high HPV16 viral load may cause an increase in the frequency of integration of virus DNA into the cellular/host genome. This suggests that a high HPV16 viral load may be considered as a risk factor for prognosis of cervical intraepithelial neoplasia and cervical cancer.

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Section: Introductionunclassified

Integrative and episomal forms of genotype 16 of human papillomavirus in patients with cervical intraepithelial neoplasia and cervical cancer

Константиновна

Цыганов

Karabut

et al. 2016

Problems of Virology

View full text Add to dashboard Cite

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Clinical and epidemiological characteristics of cancers associated with human papillomavirus in the regions of North-West Russia

Lyalina

Kholopov

Yazenok³

et al. 2023

Journal of microbiology, epidemiology and immunobiology

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Introduction. The leading role of the human papillomavirus in the etiopathogenesis of malignant neoplasms of some localizations is generally recognized. Vaccines that are used in the world and in Russia for the prevention of papillomavirus infection create the basis for the elimination of diseases associated with the human papillomavirus in the future. The aim of the study is to determine the regional, gender and age-specific features of cancers associated with the human papillomavirus to substantiate the development of a unified system of epidemiological surveillance and vaccination. Materials and methods. The retrospective epidemiological analysis of the incidence of cancers associated with the human papillomavirus and mortality due to these neoplasms in the regions of the North-Western Federal District of Russia in 20112020 was carried out based on data from Statistic Form 7 "Information on malignant neoplasms" and the Population cancer Registers of St. Petersburg (13,117 cases), Leningrad region (3204 cases) and the Kaliningrad region (2898 cases). Results. In the structure of cancers associated with the human papillomavirus in St. Petersburg, Leningrad and Kaliningrad regions, more than 90% of men had tumors of the oral cavity, oropharynx and larynx, more than 60% of women had cervical cancer. Regional and age-specific features of the incidence of cervical cancer and mortality from this pathology have been established. Statistically significant differences in the incidence of cancer of the head and neck, anus and anal canal in different age groups of the male and female population were revealed. Conclusion. As a result of the study, regional, gender and age-specific features of the incidence of human papillomavirus-associated malignant neoplasms in the North-West of Russia were established. These data should be used to develop a system of epidemiological surveillance of papillomavirus infection and vaccination program.

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Regional Experience of Cervical Cancer Prevention in the Republic of Sakha (Yakutia)

Cited by 2 publications

References 2 publications

Integrative and episomal forms of genotype 16 of human papillomavirus in patients with cervical intraepithelial neoplasia and cervical cancer

Integrative and episomal forms of genotype 16 of human papillomavirus in patients with cervical intraepithelial neoplasia and cervical cancer

Clinical and epidemiological characteristics of cancers associated with human papillomavirus in the regions of North-West Russia

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